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home:othertreatments:chemotherapy [11.13.2011]
paulalbert [Rituximab]
home:othertreatments:chemotherapy [01.03.2012] (current)
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 The additional immunosuppression caused by chemotherapy can cause symptoms over the long-term such as "chemo brain."​(({{pubmed>​long:​16381547}})) The additional immunosuppression caused by chemotherapy can cause symptoms over the long-term such as "chemo brain."​(({{pubmed>​long:​16381547}}))
  
 +==== Chemo brain ====
  
 +Brain fog (also known as "chemo brain"​) is a common side effect of chemotherapy. As demonstrated in a [[http://​www.reuters.com/​article/​2011/​11/​14/​us-cancer-breast-brain-idUSTRE7AD26V20111114|2011 study]], women with breast cancer, compared with healthy controls, had significantly reduced activation in several regions of the brain including the left middle dorsolateral prefrontal cortex, premotor cortex and left caudal lateral prefrontal cortex activation.(({{pubmed>​long:​22084128}}))
  
-===== Methotrexate ===== 
  
-Methotrexate (MTX) is an antibiotic, which interferes with bacteria'​s ability to synthesize folate. It is used to treat diseases with rapid cell growth such as cancer and some autoimmune diseases. A superior alternative to MTX is the Marshall Protocol antibiotic, Bactrim DS: 
  
-<​blockquote>​MTX is an anti-folate – actually it is an anti-dihydrofolate reductase (anti-DHFR) – which inhibits one stage in the formation of DNA. Thus any bacteria dwelling within a body which has MTX in the bloodstream will find it more difficult to replicate, and hopefully the bacteria will gradually die off. Bactrim (Sulfa/​trimeth) not only blocks DHFR (with trimethoprim) but also blocks P-ABA with Sulfonamide. Here is a diagram showing the Folate biochemistry in more detail. As you know, Bactrim is not a terribly effective antibiotic against intracellular pathogens, at least acting on its own. Neither is MTX especially effective acting on its own. 
  
-The interesting thing is that Folic Acid supplements are often given to ease the "side effects"​ of MTX. Folic Acid directly reduces the antibiotic action of both Trimethoprim and MTX. Sure, this may reduce pain from the immunopathology,​ but wouldn'​t it be more sensible to just lower the dose of MTX and reduce the risk of liver damage. 
  
-//**Trevor Marshall, PhD**// </​blockquote>​ 
-==== Discontinuing methotrexate ==== 
  
-The antibiotic action of MTX is likely to increase the immunopathology associated with olmesartan ​(Benicartherapy, which is why patients should discontinue ​MTX before starting ​the Marshall Protocol.+===== Methotrexate ===== 
 + 
 +<​mainarticle>​ [[home:​othertreatments:​antibacterials:​methotrexate|Methotrexate]] </​article>​ 
 + 
 +Methotrexate ​(MTXis an antibiotic, which interferes with bacteria'​s ability to synthesize folate. It is used to treat diseases with rapid cell growth such as cancer and some autoimmune diseases. A superior alternative to MTX is the Marshall Protocol ​antibiotic, Bactrim DS.
  
-It is not harmful to the body to discontinue MTX abruptly. This is in contrast to Prednisone, where abruptly stopping can cause a number of serious problems. Some doctors think there is a risk of rebound inflammation from stopping methotrexate abruptly. Taking a few weeks to wean from MTX, while probably not necessary, is the cautious approach to avoid the symptoms of rebound inflammation. 
  
 ===== Rituximab ===== ===== Rituximab =====
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 ===== Notes and comments ===== ===== Notes and comments =====
-TECHEDIT+
  
  
home/othertreatments/chemotherapy.txt · Last modified: 01.03.2012 (external edit)
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