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home:othertreatments:herbs_and_spices [08.25.2017] – [Notes and comments] sallieqhome:othertreatments:herbs_and_spices [11.21.2017] – [Grapefruit seed extract] + diet & drug metabolism sallieq
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 Grapefruit seed extract is a powerful, broad-spectrum antimicrobial and anti-viral agent and is therefore contraindicated. Grapefruit seed extract is a powerful, broad-spectrum antimicrobial and anti-viral agent and is therefore contraindicated.
 +
 +Grapefruit juice inhibits CYP3A4 - mediated drug metabolism [[http://www.globalrph.com/gfruit.htm|drug-grapefruit interactions]]
 +This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels. 
 +
 +see also Evans, Allan M.  in  Therapeutic Drug Monitoring: February 2000 - Volume 22 - Issue 1 - pp 131-136  
 + //Influence of Dietary Components on the Gastrointestinal Metabolism and Transport of Drugs//
  
  
home/othertreatments/herbs_and_spices.txt · Last modified: 09.14.2022 by 127.0.0.1
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