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home:othertreatments:herbs_and_spices [08.25.2017] – [Notes and comments] sallieq | home:othertreatments:herbs_and_spices [02.07.2019] – [Garlic] sallieq | ||
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==== Curcumin, tumeric, curry and mustard ==== | ==== Curcumin, tumeric, curry and mustard ==== | ||
- | MP patients | + | MP patients |
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Twelve scientific, peer-reviewed publications since 1999 suggest that curcumin, the major yellow pigment in tumeric, curry and mustard, may potentiate apoptosis or inhibit growth of selected cancer cells or function as a COX-2 inhibitor in several in-vitro and animal models.</ | Twelve scientific, peer-reviewed publications since 1999 suggest that curcumin, the major yellow pigment in tumeric, curry and mustard, may potentiate apoptosis or inhibit growth of selected cancer cells or function as a COX-2 inhibitor in several in-vitro and animal models.</ | ||
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+ | Cucurmin certainly appears to impact the immune system, and therefore it is possible that high usage may increase IP in an unpredictable way. (({{pubmed> | ||
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Garlic contains a chemical called allicin, which is a natural antibiotic.(({{pubmed> | Garlic contains a chemical called allicin, which is a natural antibiotic.(({{pubmed> | ||
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+ | We identified four anti-inflammatory sulfur-containing compounds from garlic, and their chemical structures were identified as Z- and E-ajoene and oxidized sulfonyl derivatives of ajoene. The sulfur compounds inhibited the production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) and the expression of the pro-inflammatory cytokines tumor necrosis factor-α, interleukin-1β, | ||
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+ | The optimum conditions for the formation of E- and Z-ajoene from garlic juice (({{pubmed> | ||
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+ | The treatment of macrophages with ajoene resulted in the activation of JNK, induction of ROS synthesis and accumulation of ROS, possibly leading to the activation of ER stress and autophagy. These results reveal the mechanism of the antimycobacterial effects of ajoene against Mtb H37Rv. Our findings might facilitate the development of novel therapies for patients with TB (({{pubmed> | ||
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+ | In vitro, Ajoene is toxic for several tumoral cell lines, and exert an antiproliferative effect on T. cruzi and murine malaria parasites. Here we show that Ajoene strongly inhibited the proliferation induced in human lymphocytes by the mitogens phytohemagglutinin (PHA), phorbol myristate acetate (PMA) and anti-CD3, and the capping formation induced in B lymphocytes by anti-IgM antibodies. On macrophages, | ||
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+ | Ajoene induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB (({{pubmed> | ||
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+ | In this study, we identified 18 essential oils (at 0.2% concentration) that are more active than 40 µM daptomycin (a persister drug control that could eradicate B. burgdorferi stationary phase cells), from which 10 essential oils stand out as having a remarkable activity even at 0.1% concentration (Table 1). Among them, garlic essential oil exhibited the best activity as shown by the lowest residual viability of B. burgdorferi at 0.1%. (({{pubmed> | ||
==== Grapefruit seed extract ==== | ==== Grapefruit seed extract ==== | ||
Grapefruit seed extract is a powerful, broad-spectrum antimicrobial and anti-viral agent and is therefore contraindicated. | Grapefruit seed extract is a powerful, broad-spectrum antimicrobial and anti-viral agent and is therefore contraindicated. | ||
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+ | Grapefruit juice inhibits CYP3A4 - mediated drug metabolism [[http:// | ||
+ | This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels. | ||
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The calculated affinity is high, at Ki = 54 nanomolar, about the same as the less effective ARBs and statins. As a result, only a very small amount of carnosic acid is needed to produce a negative effect. | The calculated affinity is high, at Ki = 54 nanomolar, about the same as the less effective ARBs and statins. As a result, only a very small amount of carnosic acid is needed to produce a negative effect. | ||
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+ | ==== EFA and Unsaturated oils ==== | ||
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