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home:othertreatments:herbs_and_spices [11.21.2017] – [Grapefruit seed extract] + diet & drug metabolism sallieqhome:othertreatments:herbs_and_spices [11.21.2017] – [Grapefruit seed extract] sallieq
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 Grapefruit juice inhibits CYP3A4 - mediated drug metabolism [[http://www.globalrph.com/gfruit.htm|drug-grapefruit interactions]] Grapefruit juice inhibits CYP3A4 - mediated drug metabolism [[http://www.globalrph.com/gfruit.htm|drug-grapefruit interactions]]
-This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels. +This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels.  (({{pubmed>long:10688276}}))
  
-see also Evans, Allan M.  in  Therapeutic Drug Monitoring: February 2000 - Volume 22 - Issue 1 - pp 131-136   
- //Influence of Dietary Components on the Gastrointestinal Metabolism and Transport of Drugs// 
  
  
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 The calculated affinity is high, at Ki = 54 nanomolar, about the same as the less effective ARBs and statins. As a result, only a very small amount of carnosic acid is needed to produce a negative effect. The calculated affinity is high, at Ki = 54 nanomolar, about the same as the less effective ARBs and statins. As a result, only a very small amount of carnosic acid is needed to produce a negative effect.
 +
 +==== EFA and Unsaturated oils ====
 +
 + <blockquote>Unsaturated oils, especially polyunsaturates, weaken the immune system's function in ways that are similar to the damage caused by radiation, hormone imbalance, cancer, aging, or viral infections.</blockquote>   [[http://raypeat.com/articles/articles/unsaturated-oils.shtml|article by Ray Peat]]
 +
 +<blockquote>Essential fatty acids (EFA) are, according to the textbooks, linoleic acid and linolenic acid, and they are supposed to have the status of "vitamins," which must be taken in the diet to make life possible. However, we are able to synthesize our own unsaturated fats when we don't eat the "EFA," so they are not "essential." The term thus appears to be a misnomer. [M. E. Hanke, "Biochemistry," Encycl. Brit. Book of the Year, 1948.]</blockquote>
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home/othertreatments/herbs_and_spices.txt · Last modified: 09.14.2022 by 127.0.0.1
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