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home:othertreatments:herbs_and_spices [11.21.2017] – [Grapefruit seed extract] + diet & drug metabolism sallieqhome:othertreatments:herbs_and_spices [12.15.2018] – [Curcumin, tumeric, curry and mustard] + cancer research sallieq
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 ==== Curcumin, tumeric, curry and mustard ==== ==== Curcumin, tumeric, curry and mustard ====
  
-MP patients should avoid significant use of curcumin as well as its derivatives. A 2010 by Choi //et al.// showed that curcumin decreases androgen receptor expression in a dose-dependent manner.(({{pubmed>long:20680030}})) According to a 2006 Food Technology article: +MP patients aree advised to avoid significant use of curcumin as well as its derivatives. A 2010 by Choi //et al.// showed that curcumin decreases androgen receptor expression in a dose-dependent manner.(({{pubmed>long:20680030}})) According to a 2006 Food Technology article: 
  
 <blockquote> <blockquote>
 Twelve scientific, peer-reviewed publications since 1999 suggest that curcumin, the major yellow pigment in tumeric, curry and mustard, may potentiate apoptosis or inhibit growth of selected cancer cells or function as a COX-2 inhibitor in several in-vitro and animal models.</blockquote> Twelve scientific, peer-reviewed publications since 1999 suggest that curcumin, the major yellow pigment in tumeric, curry and mustard, may potentiate apoptosis or inhibit growth of selected cancer cells or function as a COX-2 inhibitor in several in-vitro and animal models.</blockquote>
 +
 +Cucurmin certainly appears to impact the immune system, and therefore may increasse IP in an unpredictable way.  (({{pubmed>long:27874279}}))  (({{pubmed>long:21461234}}))
  
  
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 Grapefruit juice inhibits CYP3A4 - mediated drug metabolism [[http://www.globalrph.com/gfruit.htm|drug-grapefruit interactions]] Grapefruit juice inhibits CYP3A4 - mediated drug metabolism [[http://www.globalrph.com/gfruit.htm|drug-grapefruit interactions]]
-This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels. +This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels.  (({{pubmed>long:10688276}}))
  
-see also Evans, Allan M.  in  Therapeutic Drug Monitoring: February 2000 - Volume 22 - Issue 1 - pp 131-136   
- //Influence of Dietary Components on the Gastrointestinal Metabolism and Transport of Drugs// 
  
  
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 The calculated affinity is high, at Ki = 54 nanomolar, about the same as the less effective ARBs and statins. As a result, only a very small amount of carnosic acid is needed to produce a negative effect. The calculated affinity is high, at Ki = 54 nanomolar, about the same as the less effective ARBs and statins. As a result, only a very small amount of carnosic acid is needed to produce a negative effect.
 +
 +==== EFA and Unsaturated oils ====
 +
 + <blockquote>Unsaturated oils, especially polyunsaturates, weaken the immune system's function in ways that are similar to the damage caused by radiation, hormone imbalance, cancer, aging, or viral infections.</blockquote>   [[http://raypeat.com/articles/articles/unsaturated-oils.shtml|article by Ray Peat]]
 +
 +<blockquote>Essential fatty acids (EFA) are, according to the textbooks, linoleic acid and linolenic acid, and they are supposed to have the status of "vitamins," which must be taken in the diet to make life possible. However, we are able to synthesize our own unsaturated fats when we don't eat the "EFA," so they are not "essential." The term thus appears to be a misnomer. [M. E. Hanke, "Biochemistry," Encycl. Brit. Book of the Year, 1948.]</blockquote>
 +
  
  
home/othertreatments/herbs_and_spices.txt · Last modified: 09.14.2022 by 127.0.0.1
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