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home:othertreatments:herbs_and_spices [12.15.2018] – [Curcumin, tumeric, curry and mustard] sallieqhome:othertreatments:herbs_and_spices [09.14.2022] (current) – external edit 127.0.0.1
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 ==== Curcumin, tumeric, curry and mustard ==== ==== Curcumin, tumeric, curry and mustard ====
  
-MP patients are advised to avoid significant use of curcumin as well as its derivatives. A 2010 by Choi //et al.// showed that curcumin decreases androgen receptor expression in a dose-dependent manner.(({{pubmed>long:20680030}})) According to a 2006 Food Technology article: +MP patients are advised to avoid significant use of curcumin as well as its derivatives. A 2010 by Choi //et al.// showed that curcumin decreases androgen receptor expression in a dose-dependent manner.(({{pmid>long:20680030}})) According to a 2006 Food Technology article: 
  
 <blockquote> <blockquote>
 Twelve scientific, peer-reviewed publications since 1999 suggest that curcumin, the major yellow pigment in tumeric, curry and mustard, may potentiate apoptosis or inhibit growth of selected cancer cells or function as a COX-2 inhibitor in several in-vitro and animal models.</blockquote> Twelve scientific, peer-reviewed publications since 1999 suggest that curcumin, the major yellow pigment in tumeric, curry and mustard, may potentiate apoptosis or inhibit growth of selected cancer cells or function as a COX-2 inhibitor in several in-vitro and animal models.</blockquote>
  
-Cucurmin certainly appears to impact the immune system, and therefore it is possible that high usage may increase IP in an unpredictable way.  (({{pubmed>long:27874279}}))  (({{pubmed>long:21461234}}))+Cucurmin certainly appears to impact the immune system, and therefore it is possible that high usage may increase IP in an unpredictable way.  (({{pmid>long:27874279}}))  (({{pmid>long:21461234}}))
  
  
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 ==== Garlic ==== ==== Garlic ====
  
-Garlic contains a chemical called allicin, which is a natural antibiotic.(({{pubmed>long:2469386}})) Allicin is known to inhibit bacterial cell growth. Garlic tablets taken as a supplement may interact unpredictably with MP medications and could be potentially detrimental. Eating moderate amounts of garlic as part of one's diet, however, is probably not detrimental to progress on the MP.+Garlic contains a chemical called allicin, which is a natural antibiotic.(({{pmid>long:2469386}})) Allicin is known to inhibit bacterial cell growth. Garlic tablets taken as a supplement may interact unpredictably with MP medications and could be potentially detrimental. Eating moderate amounts of garlic as part of one's diet, however, is probably not detrimental to progress on the MP.
  
 +[[https://aac.asm.org/content/56/5/2314|Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing]]
  
 +We identified four anti-inflammatory sulfur-containing compounds from garlic, and their chemical structures were identified as Z- and E-ajoene and oxidized sulfonyl derivatives of ajoene. The sulfur compounds inhibited the production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) and the expression of the pro-inflammatory cytokines tumor necrosis factor-α, interleukin-1β, and interleukin-6 in lipopolysaccharide (LPS)-activated macrophages. (({{pmid>long:23057778}})) 
 +
 +The optimum conditions for the formation of E- and Z-ajoene from garlic juice (({{pmid>long:25473520}})) 
 +
 +The treatment of macrophages with ajoene resulted in the activation of JNK, induction of ROS synthesis and accumulation of ROS, possibly leading to the activation of ER stress and autophagy. These results reveal the mechanism of the antimycobacterial effects of ajoene against Mtb H37Rv. Our findings might facilitate the development of novel therapies for patients with TB (({{pmid>long:29239661}})) 
 +
 + In vitro, Ajoene is toxic for several tumoral cell lines, and exert an antiproliferative effect on T. cruzi and murine malaria parasites. Here we show that Ajoene strongly inhibited the proliferation induced in human lymphocytes by the mitogens phytohemagglutinin (PHA), phorbol myristate acetate (PMA) and anti-CD3, and the capping formation induced in B lymphocytes by anti-IgM antibodies. On macrophages, Ajoene was also found to partially inhibit the lypopolysaccharide-induced production of Tumor Necrosis Factor (TNF), and to decrease the phagocytic activity of thioglycolate-elicited mouse peritoneal macrophages for IgG-opsonized, human erythrocytes. Ajoene also partially prevented the lytic effect of human and rabbit TNF on Actinomycin D-treated WEHI 164 cells. These results strongly suggest that Ajoene is a potent modulator of membrane-dependent functions of immune cells. (({{pmid>long:9049657}})) 
 +
 +Ajoene induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB (({{pmid>long:9495804}})) 
 +
 +In this study, we identified 18 essential oils (at 0.2% concentration) that are more active than 40 µM daptomycin (a persister drug control that could eradicate B. burgdorferi stationary phase cells), from which 10 essential oils stand out as having a remarkable activity even at 0.1% concentration (Table 1). Among them, garlic essential oil exhibited the best activity as shown by the lowest residual viability of B. burgdorferi at 0.1%. (({{pmid>long:30332754}})) 
 ==== Grapefruit seed extract ==== ==== Grapefruit seed extract ====
  
 Grapefruit seed extract is a powerful, broad-spectrum antimicrobial and anti-viral agent and is therefore contraindicated. Grapefruit seed extract is a powerful, broad-spectrum antimicrobial and anti-viral agent and is therefore contraindicated.
  
-Grapefruit juice inhibits CYP3A4 - mediated drug metabolism [[http://www.globalrph.com/gfruit.htm|drug-grapefruit interactions]] +Grapefruit juice inhibits CYP3A4 - mediated drug metabolism [[https://www.globalrph.com/gfruit.htm|drug-grapefruit interactions]] 
-This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels.  (({{pubmed>long:10688276}}))+This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels.  (({{pmid>long:10688276}}))
  
  
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 ==== Milk thistle ==== ==== Milk thistle ====
  
-Right upper quadrant pain (which corresponds to the liver's location) is often relieved with the use of Silymarin/milk thistle, which is available in capsule form. Milk thistle is made from //Silybum marianum// seeds. Some researchers believe that milk thistle supplements have a detoxifying action reducing toxicity of the liver.(({{pubmed>long:17548794}})) +Right upper quadrant pain (which corresponds to the liver's location) is often relieved with the use of Silymarin/milk thistle, which is available in capsule form. Milk thistle is made from //Silybum marianum// seeds. Some researchers believe that milk thistle supplements have a detoxifying action reducing toxicity of the liver.(({{pmid>long:17548794}})) 
  
 With herbs such as this, it is difficult to measure the active ingredient potency. Since it all comes from plants, they vary with growing conditions. For that reason, some brands may seem to work better than others. With herbs such as this, it is difficult to measure the active ingredient potency. Since it all comes from plants, they vary with growing conditions. For that reason, some brands may seem to work better than others.
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 For quick relief (especially when the digestive system is not working well), liquid milk thistle drops, which are usually available from a local health food store, may be helpful. Drops can be used in addition to the capsules, if needed. For quick relief (especially when the digestive system is not working well), liquid milk thistle drops, which are usually available from a local health food store, may be helpful. Drops can be used in addition to the capsules, if needed.
  
-The  Natural Medicines Comprehensive Database describes [[http://naturaldatabaseconsumer.therapeuticresearch.com/nd/Search.aspx?cs=KAISER&s=NDC&pt=100&sh=1&id=138#safety|safety and drug interactions]] that anyone considering its use may want to review. +The  Natural Medicines Comprehensive Database describes [[https://naturaldatabaseconsumer.therapeuticresearch.com/nd/Search.aspx?cs=KAISER&s=NDC&pt=100&sh=1&id=138#safety|safety and drug interactions]] that anyone considering its use may want to review. 
 ==== Olive leaf extract ==== ==== Olive leaf extract ====
  
-Olive leaf extract (not to be confused with olive oil) is touted as an anti-viral, especially to patients suffering from CFS. Olive leaf extract may contain vitamin D according to at least one [[http://www.patentstorm.us/patents/5776461-description.html|application for patent]]. As a result, MP patients should not consume olive leaf extract. (The use of olive //oil// is not contraindicated, however.)+Olive leaf extract (not to be confused with olive oil) is touted as an anti-viral, especially to patients suffering from CFS. Olive leaf extract may contain vitamin D according to at least one [[https://www.patentstorm.us/patents/5776461-description.html|application for patent]]. As a result, MP patients should not consume olive leaf extract. (The use of olive //oil// is not contraindicated, however.)
  
  
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 ==== EFA and Unsaturated oils ==== ==== EFA and Unsaturated oils ====
  
- <blockquote>Unsaturated oils, especially polyunsaturates, weaken the immune system's function in ways that are similar to the damage caused by radiation, hormone imbalance, cancer, aging, or viral infections.</blockquote>   [[http://raypeat.com/articles/articles/unsaturated-oils.shtml|article by Ray Peat]]+ <blockquote>Unsaturated oils, especially polyunsaturates, weaken the immune system's function in ways that are similar to the damage caused by radiation, hormone imbalance, cancer, aging, or viral infections.</blockquote>   [[https://raypeat.com/articles/articles/unsaturated-oils.shtml|article by Ray Peat]]
  
 <blockquote>Essential fatty acids (EFA) are, according to the textbooks, linoleic acid and linolenic acid, and they are supposed to have the status of "vitamins," which must be taken in the diet to make life possible. However, we are able to synthesize our own unsaturated fats when we don't eat the "EFA," so they are not "essential." The term thus appears to be a misnomer. [M. E. Hanke, "Biochemistry," Encycl. Brit. Book of the Year, 1948.]</blockquote> <blockquote>Essential fatty acids (EFA) are, according to the textbooks, linoleic acid and linolenic acid, and they are supposed to have the status of "vitamins," which must be taken in the diet to make life possible. However, we are able to synthesize our own unsaturated fats when we don't eat the "EFA," so they are not "essential." The term thus appears to be a misnomer. [M. E. Hanke, "Biochemistry," Encycl. Brit. Book of the Year, 1948.]</blockquote>
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 {{tag>supplements }} {{tag>supplements }}
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
-broke [[http://tinyurl.com/nflgz|2006 Food Technology article]]+broke [[https://tinyurl.com/nflgz|2006 Food Technology article]]
  
  
   * Legacy content   * Legacy content
-    * http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=71232#p71232 f32+    * https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=71232#p71232 f32
     *      * 
     *      * 
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 From: BIGDOG From: BIGDOG
 Date: 2011-03-27 22:00:50 Date: 2011-03-27 22:00:50
-Reply: http://www.marshallprotocol.com/reply.php?topic_id=14054+Reply: https://www.marshallprotocol.com/reply.php?topic_id=14054
  
 Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes
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 From: BIGDOG From: BIGDOG
 Date: 2011-03-27 22:06:44 Date: 2011-03-27 22:06:44
-Reply: http://www.marshallprotocol.com/reply.php?topic_id=14054+Reply: https://www.marshallprotocol.com/reply.php?topic_id=14054
  
 Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model. Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.
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-http://www.jstage.jst.go.jp/article/bpb/33/12/1977/_pdf+https://www.jstage.jst.go.jp/article/bpb/33/12/1977/_pdf
  
  
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 </blockquote> </blockquote>
-===== References =====+===== References =====</nodisp> 
home/othertreatments/herbs_and_spices.txt · Last modified: 09.14.2022 by 127.0.0.1
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