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home:othertreatments:hormone_therapy [10.25.2018]
sallieq [Patients experiences]
home:othertreatments:hormone_therapy [08.01.2019] (current)
sallieq [Hormone replacement therapy upsets cellular homeostasis]
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 For example, if a patient is given testosterone,​ some of that testosterone enters the cell. Increased levels of testosterone may reduce the transcriptional activity of the Androgen Receptor, the nuclear receptor which produces it. One possibility is that with reduced production of testosterone,​ the Androgen Receptor also reduces transcription in other ways, leading to a reduction in the production of certain families of antimicrobial peptides, which many active Type I nuclear receptors also produce.(({{pubmed>​long:​17254313}})) Therefore, hormone replacement therapy //may// compromise innate immune function in dose-dependent fashion. Research is needed to validate this theory. For example, if a patient is given testosterone,​ some of that testosterone enters the cell. Increased levels of testosterone may reduce the transcriptional activity of the Androgen Receptor, the nuclear receptor which produces it. One possibility is that with reduced production of testosterone,​ the Androgen Receptor also reduces transcription in other ways, leading to a reduction in the production of certain families of antimicrobial peptides, which many active Type I nuclear receptors also produce.(({{pubmed>​long:​17254313}})) Therefore, hormone replacement therapy //may// compromise innate immune function in dose-dependent fashion. Research is needed to validate this theory.
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 +Research into estrogen plus progestin therapy showed increased risks, 7 more CHD events, 8 more strokes, 8 more PEs, and 8 more invasive breast cancers. (16608 healthy postmenopausal women studied over 5 years) (({{pubmed>​long:​12117397}}))
  
  
home/othertreatments/hormone_therapy.txt · Last modified: 08.01.2019 by sallieq
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