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home:othertreatments:immune_suppressants [11.01.2018] – [Nuclear receptors and ligands] +section on unsaturated & fish oils sallieq | home:othertreatments:immune_suppressants [12.19.2018] – [Nuclear receptors and ligands] sallieq | ||
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+ | ===== Introduction ===== | ||
Because palliative treatments that slow immune function are very effective at offering temporary relief, the number of medications, | Because palliative treatments that slow immune function are very effective at offering temporary relief, the number of medications, | ||
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It is commonly accepted that most ligands, approximately 95% to 98%, inactivate the nuclear receptors. Since the nuclear receptors play a significant role in the immune response, this factor alone may explain why so many drugs and substances found in food and drink are immunosuppressive. | It is commonly accepted that most ligands, approximately 95% to 98%, inactivate the nuclear receptors. Since the nuclear receptors play a significant role in the immune response, this factor alone may explain why so many drugs and substances found in food and drink are immunosuppressive. | ||
- | Because the expression of a large number of genes is regulated by nuclear receptors, ligands that activate these receptors can have profound effects on the organism. Many of these regulated genes are associated with various diseases which explains why the molecular targets of approximately 13% of FDA approved drugs are nuclear receptors.6) | + | Because the expression of a large number of genes is regulated by nuclear receptors, ligands that activate these receptors can have profound effects on the organism. Many of these regulated genes are associated with various diseases which explains why the molecular targets of approximately 13% of FDA approved drugs are nuclear receptors. |
Different cell types have different nuclear receptors. One of the nuclear receptors seen in immune cells is the Vitamin D Receptor (VDR). The VDR has two endogenous or “native” ligands, which are also the two main forms of vitamin D in the human body: 25-hydroxyvitamin D (25-D) and 1, | Different cell types have different nuclear receptors. One of the nuclear receptors seen in immune cells is the Vitamin D Receptor (VDR). The VDR has two endogenous or “native” ligands, which are also the two main forms of vitamin D in the human body: 25-hydroxyvitamin D (25-D) and 1, | ||
- | When functioning properly, the VDR transcribes between | + | When functioning properly, the VDR transcribes between |
The body controls activity of the VDR through regulation of the vitamin D metabolites. 25-hydroxyvitamin D (25-D) antagonizes or inactivates the Receptor while 1, | The body controls activity of the VDR through regulation of the vitamin D metabolites. 25-hydroxyvitamin D (25-D) antagonizes or inactivates the Receptor while 1, | ||
- | More than 36 types of tissue have been identified as having a Vitamin D Receptor.5) | + | More than 36 types of tissue have been identified as having a Vitamin D Receptor. |
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He was making the point that the immunosuppressive effects of PUFs in sunflower seeds are useful in treating autoimmune diseases such as multiple sclerosis, | He was making the point that the immunosuppressive effects of PUFs in sunflower seeds are useful in treating autoimmune diseases such as multiple sclerosis, | ||
... | ... | ||
- | It was during the early days of kidney transplantation that doctors first encountered the problem of tissue rejection as their patients’ bodies destroyed the alien transplanted kidneys. If transplantation were to be a success, they had to find a way to suppress the immune system. Newsholme had said that there was no better way to immunosuppress a renal patient than with sunflower seed oil. So kidney transplant doctors fed their patients linoleic acid.[iii] (Linoleic acid is the major polyunsaturated fatty acid in vegetable oils.) But the transplant doctors were then astonished to see how quickly their patients developed cancers and the treatment was stopped. | + | It was during the early days of kidney transplantation that doctors first encountered the problem of tissue rejection as their patients’ bodies destroyed the alien transplanted kidneys. If transplantation were to be a success, they had to find a way to suppress the immune system. Newsholme had said that there was no better way to immunosuppress a renal patient than with sunflower seed oil. So kidney transplant doctors fed their patients linoleic acid.[iii] (Linoleic acid is the major polyunsaturated fatty acid in vegetable oils. But the transplant doctors were then astonished to see how quickly their patients developed cancers and the treatment was stopped. |
In 1989 there was a report of a 10-year trial at a Veterans’ Administration Hospital in Los Angeles. In this trial half the patients were fed a diet which had twice as much PUFs as saturated fats. In the half of patients on the high PUF diet there was a 15% increase in cancer deaths compared to the saturated fat group.[v] The authors of the report said that the PUFs had been the cause of the increase in cancer deaths. The 6 October 1973 issue of the British Medical Journal asked if PUFs were carcinogenic and came to the conclusion that they were. | In 1989 there was a report of a 10-year trial at a Veterans’ Administration Hospital in Los Angeles. In this trial half the patients were fed a diet which had twice as much PUFs as saturated fats. In the half of patients on the high PUF diet there was a 15% increase in cancer deaths compared to the saturated fat group.[v] The authors of the report said that the PUFs had been the cause of the increase in cancer deaths. The 6 October 1973 issue of the British Medical Journal asked if PUFs were carcinogenic and came to the conclusion that they were. | ||
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Newsholme EA. Mechanism for starvation suppression and refeeding activation of infection.(({{pubmed> | Newsholme EA. Mechanism for starvation suppression and refeeding activation of infection.(({{pubmed> | ||
- | (({{pubmed> | ||
- | (({{pubmed> | ||
"With a high intake of margarine and cooking oils, a tumour may grow too rapidly for the weakened immune system to cope thus increasing our risk of a cancer." | "With a high intake of margarine and cooking oils, a tumour may grow too rapidly for the weakened immune system to cope thus increasing our risk of a cancer." | ||
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+ | ==== Immune suppression in the modern world ==== | ||
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+ | Modern technology brings a whole new challenge to the human immune system | ||
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+ | For this reason, a series of extracts from discussion "How Radio Waves Make You Sicker" | ||
+ | are being added to this Knowledge database | ||
+ | |||
==== Innate immune response==== | ==== Innate immune response==== | ||
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- | <note important> | ||
So long as one is responding to olmesartan or olmesartan plus antibiotics with symptoms that wax and wane, there are still bacteria to be killed. | So long as one is responding to olmesartan or olmesartan plus antibiotics with symptoms that wax and wane, there are still bacteria to be killed. | ||
- | {{tag> | + | {{tag> |
===== Notes and comments ===== | ===== Notes and comments ===== | ||
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+ | ===== References ===== | ||
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