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home:othertreatments:immune_suppressants [12.19.2018] – [Nuclear receptors and ligands] sallieqhome:othertreatments:immune_suppressants [12.19.2018] – [Immune suppression in the modern world] sallieq
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 The first person to suggest that polyunsaturated fats[PUFs] suppress the immune system was Dr E A Newsholme of Oxford University, England. What Newsholme wrote was that when our bodies get sufficient nutrition, our diet includes immunosuppressive PUFs which make us prone to infection by bacteria and viruses. The first person to suggest that polyunsaturated fats[PUFs] suppress the immune system was Dr E A Newsholme of Oxford University, England. What Newsholme wrote was that when our bodies get sufficient nutrition, our diet includes immunosuppressive PUFs which make us prone to infection by bacteria and viruses.
 ... ...
-He was making the point that the immunosuppressive effects of PUFs in sunflower seeds are useful in treating autoimmune diseases such as multiple sclerosis,[ii] and that the same fatty acids could be used to suppress the immune system to prevent rejection of kidney transplants.+He was making the point that the immunosuppressive effects of PUFs in sunflower seeds are useful in treating autoimmune diseases such as multiple sclerosis, and that the same fatty acids could be used to suppress the immune system to prevent rejection of kidney transplants.
 ... ...
-It was during the early days of kidney transplantation that doctors first encountered the problem of tissue rejection as their patients’ bodies destroyed the alien transplanted kidneys. If transplantation were to be a success, they had to find a way to suppress the immune system. Newsholme had said that there was no better way to immunosuppress a renal patient than with sunflower seed oil. So kidney transplant doctors fed their patients linoleic acid.[iii] (Linoleic acid is the major polyunsaturated fatty acid in vegetable oils. But the transplant doctors were then astonished to see how quickly their patients developed cancers and the treatment was stopped.+It was during the early days of kidney transplantation that doctors first encountered the problem of tissue rejection as their patients’ bodies destroyed the alien transplanted kidneys. If transplantation were to be a success, they had to find a way to suppress the immune system. Newsholme had said that there was no better way to immunosuppress a renal patient than with sunflower seed oil. So kidney transplant doctors fed their patients linoleic acid. (Linoleic acid is the major polyunsaturated fatty acid in vegetable oils. But the transplant doctors were then astonished to see how quickly their patients developed cancers and the treatment was stopped.
  
-In 1989 there was a report of a 10-year trial at a Veterans’ Administration Hospital in Los Angeles. In this trial half the patients were fed a diet which had twice as much PUFs as saturated fats. In the half of patients on the high PUF diet there was a 15% increase in cancer deaths compared to the saturated fat group.[v] The authors of the report said that the PUFs had been the cause of the increase in cancer deaths. The 6 October 1973 issue of the British Medical Journal asked if PUFs were carcinogenic and came to the conclusion that they were.+In 1989 there was a report of a 10-year trial at a Veterans’ Administration Hospital in Los Angeles. In this trial half the patients were fed a diet which had twice as much PUFs as saturated fats. In the half of patients on the high PUF diet there was a 15% increase in cancer deaths compared to the saturated fat group. The authors of the report said that the PUFs had been the cause of the increase in cancer deaths. The 6 October 1973 issue of the British Medical Journal asked if PUFs were carcinogenic and came to the conclusion that they were.
 ... ...
 In 1990, Martin called Newsholme’s Oxford University office but by then Newsholme had retired. Martin spoke to his successor to find that they were still treating autoimmune diseases with PUFs. By then they were using fish oil. The Oxford doctor said the reason for the fish oil was that the degree of immunosuppression increased with the degree of unsaturation and fish oil was much more unsaturated than sunflower oil. Martin asked the doctor why they were not talking about PUFs causing cancer. The doctor replied that if he did that he would be run out of Oxford.  In 1990, Martin called Newsholme’s Oxford University office but by then Newsholme had retired. Martin spoke to his successor to find that they were still treating autoimmune diseases with PUFs. By then they were using fish oil. The Oxford doctor said the reason for the fish oil was that the degree of immunosuppression increased with the degree of unsaturation and fish oil was much more unsaturated than sunflower oil. Martin asked the doctor why they were not talking about PUFs causing cancer. The doctor replied that if he did that he would be run out of Oxford. 
 //**Above paragraphs quoted from blog**// [[http://www.functionalps.com/blog/2011/09/22/polyunsaturated-fats-suppress-the-immune-system/|Team FPS]] //**Above paragraphs quoted from blog**// [[http://www.functionalps.com/blog/2011/09/22/polyunsaturated-fats-suppress-the-immune-system/|Team FPS]]
      
-Miller JHD, et al. Double blind trial of linoleate supplementation in the diet in multiple sclerosis. BMJ 1973; i: 765-8.(({{pubmed>long:4571680}})<blockquote>Seventy-five patients in London and Belfast with multiple sclerosis were given daily supplements of a vegetable oil mixture containing either linoleate or oleate for two years in a double-blind control trial. Relapses tended to be less frequent and were significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.+Miller JHD, et al. Double blind trial of linoleate supplementation in the diet in multiple sclerosis. BMJ 1973; i: 765-8.(({{pubmed>long:4571680}})) 
 +<blockquote>Seventy-five patients in London and Belfast with multiple sclerosis were given daily supplements of a vegetable oil mixture containing either linoleate or oleate for two years in a double-blind control trial. Relapses tended to be less frequent and were significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.
 </blockquote> </blockquote>
  
 Uldall PR, et al. Unsaturated fatty acids and renal transplantation. Lancet 1974; ii: 514.(({{pubmed>long:4137027}})) Uldall PR, et al. Unsaturated fatty acids and renal transplantation. Lancet 1974; ii: 514.(({{pubmed>long:4137027}}))
  
- Pearce M L, Dayton S. Incidence of cancer in men on a diet high in polyunsaturated fat. Lancet 1971; i: 464.(({{pubmed>long:4100347}}))<blockquote>In an eight-year controlled clinical trial of a diet high in polyunsaturated vegetable oils and low in saturated fat and cholesterol in preventing complications of atherosclerosis, 846 men were assigned randomly to a conventional diet or to one similar in all respects except for a substitution of vegetable oils for saturated fat. Fatal atherosclerotic events were more common in the control group (70 v.48; P<0·05). However, total mortality was similar in the two groups: 178 controls v. 174 experimentals, demonstrating an excess of non-atherosclerotic deaths in the experimental group. This was accounted for by a greater incidence of fatal carcinomas in the experimental group. 31 of 174 deaths in the experimental group were due to cancer, as opposed to 17 of 178 deaths in the control group (P=0·06).+ Pearce M L, Dayton S. Incidence of cancer in men on a diet high in polyunsaturated fat. Lancet 1971; i: 464.(({{pubmed>long:4100347}})) 
 +<blockquote>In an eight-year controlled clinical trial of a diet high in polyunsaturated vegetable oils and low in saturated fat and cholesterol in preventing complications of atherosclerosis, 846 men were assigned randomly to a conventional diet or to one similar in all respects except for a substitution of vegetable oils for saturated fat. Fatal atherosclerotic events were more common in the control group (70 v.48; P<0·05). However, total mortality was similar in the two groups: 178 controls v. 174 experimentals, demonstrating an excess of non-atherosclerotic deaths in the experimental group. This was accounted for by a greater incidence of fatal carcinomas in the experimental group. 31 of 174 deaths in the experimental group were due to cancer, as opposed to 17 of 178 deaths in the control group (P=0·06).
 </blockquote> </blockquote>
  
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 "With a high intake of margarine and cooking oils, a tumour may grow too rapidly for the weakened immune system to cope thus increasing our risk of a cancer." "With a high intake of margarine and cooking oils, a tumour may grow too rapidly for the weakened immune system to cope thus increasing our risk of a cancer."
  
-==== Immune suppression in the modern world ==== 
- 
-Modern technology brings a whole new challenge to the human immune system 
- 
-For this reason, a series of extracts from discussion "How Radio Waves Make You Sicker" among patients following the Marshall Protocol 
-are being added to this Knowledge database  
  
  
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 So long as one is responding to olmesartan or olmesartan plus antibiotics with symptoms that wax and wane, there are still bacteria to be killed.  So long as one is responding to olmesartan or olmesartan plus antibiotics with symptoms that wax and wane, there are still bacteria to be killed. 
  
-{{tag>immunosuppressant  non-MP_therapies Special_issues special arrange}}+===== Immune suppression in the modern world ===== 
 + 
 +Modern technology brings a whole new challenge to the human immune system 
 + 
 +For this reason, a series of extracts from discussion "How Radio Waves Make You Sicker" among patients following the Marshall Protocol 
 +are being added to this Knowledge database  
 + 
 +{{tag>immunosuppressant  non-MP_therapies Special_issues special }}
  
  
home/othertreatments/immune_suppressants.txt · Last modified: 09.14.2022 by 127.0.0.1
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