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home:othertreatments:pain_medication [02.07.2019] – [Pain medications and muscle relaxants] sallieqhome:othertreatments:pain_medication [09.01.2019] – [Opioids] sallieq
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   * **morphine** – avoid if possible - shown to be immunosuppressive in a study(({{pubmed>long:9208156}}))   * **morphine** – avoid if possible - shown to be immunosuppressive in a study(({{pubmed>long:9208156}}))
   * **naltrexone** – an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. Naltrexone would certainly appear to affect the ability of the MP to return the human immune system to full function again. Lymphocytes express opioid receptors, probably for a good reason. Even though that reason is not fully understood, it is not a good idea to block those opioid receptors (with naltrexone) if one expects to be able to return your immune system to normal.   * **naltrexone** – an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. Naltrexone would certainly appear to affect the ability of the MP to return the human immune system to full function again. Lymphocytes express opioid receptors, probably for a good reason. Even though that reason is not fully understood, it is not a good idea to block those opioid receptors (with naltrexone) if one expects to be able to return your immune system to normal.
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 +Ultra-low dose naltrexone enhances cannabinoid-induced antinociception.  (({{pubmed>long:16286810}}))
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 +Surprisingly, the analgesic effects of opioids are enhanced by ultra-low doses (nanomolar to picomolar) of the opioid antagonist, naltrexone.
  
 <blockquote>Low dose naltrexone (LDN) is palliative. It doesn't help the innate immune system in any significant way. If it were helping the immune system to kill the microbiota then your immunopathology would increase, not decrease. However, I have looked into whether it is likely to stop healing, and it does not seem to interfere with the known actions of Olmesartan on the VDR. So it seems a "safe" palliative. There was a [[http://www.curemyth1.org/view_topic.php?id=3589&forum_id=2&jump_to=31773|thread on CureMyTh1.org]] where these issues were briefly discussed. <blockquote>Low dose naltrexone (LDN) is palliative. It doesn't help the innate immune system in any significant way. If it were helping the immune system to kill the microbiota then your immunopathology would increase, not decrease. However, I have looked into whether it is likely to stop healing, and it does not seem to interfere with the known actions of Olmesartan on the VDR. So it seems a "safe" palliative. There was a [[http://www.curemyth1.org/view_topic.php?id=3589&forum_id=2&jump_to=31773|thread on CureMyTh1.org]] where these issues were briefly discussed.
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 ==== Opioids ==== ==== Opioids ====
  
-Opioids are the preferred method of dealing with extreme pain in the MP cohort. +Temporary use of opioids are the preferred method of dealing with **extreme** pain in the MP cohort. 
  
 An opioid is any agent that binds to opioid receptors, found principally in the central nervous system and gastrointestinal tract. Opioids work to relieve pain in two ways. First, they attach to opioid receptors, which are specific proteins on the surface of cells in the brain, spinal cord and gastrointestinal tract. These drugs interfere and stop the transmission of pain messages to the brain. Second, they work in the brain to alter the sensation of pain. These drugs do not take the pain away, but they do reduce and alter the patient’s perception of the pain. An opioid is any agent that binds to opioid receptors, found principally in the central nervous system and gastrointestinal tract. Opioids work to relieve pain in two ways. First, they attach to opioid receptors, which are specific proteins on the surface of cells in the brain, spinal cord and gastrointestinal tract. These drugs interfere and stop the transmission of pain messages to the brain. Second, they work in the brain to alter the sensation of pain. These drugs do not take the pain away, but they do reduce and alter the patient’s perception of the pain.
home/othertreatments/pain_medication.txt · Last modified: 09.14.2022 by 127.0.0.1
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