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home:othertreatments:sunshine [09.20.2011] – [Notes and comments] paulalberthome:othertreatments:sunshine [06.30.2019] – [Sunlight can be immunosuppressive] sallieq
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 <relatedsection>  [[home:lifestyle:light:photosensitivity?&#effect_of_light_on_the_skin|Effect of light on the skin]]</section> <relatedsection>  [[home:lifestyle:light:photosensitivity?&#effect_of_light_on_the_skin|Effect of light on the skin]]</section>
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 +Phototherapy suppresses immunity which can lead to the progression of other infections such as human papilloma virus (HPV). A 2010 study used a nested polymerase chain reaction, to analyze skin biopsies taken a from 20 psoriasis patients under phototherapy (UVB) and 20 untreated psoriatic patients. The authors were able to detect viruses in 60% of the treatment but in none of the controls.(({{pubmed>long:20415738}})) 
 +
 +1,25(OH)2D3 resulted in suppression of proinflammatory cytokine response in vitro
 +First, we carried out LPS and Pam3Cys stimulation on PBMC with the addition of 100 nM 1,25(OH)2D3. After 24 h, IL-6 secretion was reduced by 53% and 29% upon Pam3Cys and LPS stimulation, respectively, in the cells treated with 1,25(OH)2D3 (Fig. 1a). A significant drop in TNF-α production by 17% (Pam3Cys stimulation) and 35% (LPS stimulation) was also observed with 1,25(OH)2D3 at 24 h. Having demonstrated that 1,25(OH)2D3 had the capacity to modulated IL-6 and TNF-α response in vitro, and with the understanding that physiological vitamin D3 levels in the body may vary through the seasons, we validate these observations in vivo in a cohort of healthy volunteers.(({{pubmed>long:21323660}}))
  
 A 2011 study by Damian //et al.// concluded that exposure to sunlight even at suberythemal levels – sunlight which doesn't cause redness – is "profoundly immunosuppressive" in humans and that it is the immune-suppressive effects of sunlight that play a central role in skin carcinogenesis.(({{pubmed>long:21375518}})) A 2011 study by Damian //et al.// concluded that exposure to sunlight even at suberythemal levels – sunlight which doesn't cause redness – is "profoundly immunosuppressive" in humans and that it is the immune-suppressive effects of sunlight that play a central role in skin carcinogenesis.(({{pubmed>long:21375518}}))
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 +Certain support for this study comes from a 2011 Australian paper that found that 8 week old mice given a single exposure of ultraviolet radiation had suppressed immunity.(({{pubmed>long:21243005}}))
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 +[[http://www.nejm.org/doi/full/10.1056/NEJMicm1104059|Unilateral Dermatoheliosis]]
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 ===== By providing temporary symptom relief, tanning may be addictive ===== ===== By providing temporary symptom relief, tanning may be addictive =====
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  //**Penny,** MarshallProtocol.com// </blockquote>  //**Penny,** MarshallProtocol.com// </blockquote>
  
-{{tag>light}}+{{tag>Lifestyle_modifications light}}
  
 ===== Read more ===== ===== Read more =====
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   * [[http://www.truenudists.com/forum/viewthread.php?id=1480&post=15509|"Why Am I Sick?" (Nudist Forum)]] - a number of devoted nudists complain about their symptoms of inflammatory disease   * [[http://www.truenudists.com/forum/viewthread.php?id=1480&post=15509|"Why Am I Sick?" (Nudist Forum)]] - a number of devoted nudists complain about their symptoms of inflammatory disease
   * [[http://news.nationalgeographic.com/news/2009/05/090508-sunlight-suicide.html|Too Much Sunshine Spurs Suicides in Arctic, Study Says]] – review of a 2009 //BMC Psychiatry// article,((Björkstén. [[http://www.biomedcentral.com/content/pdf/1471-244x-9-20.pdf|Accentuation of suicides but not homicides with rising latitudes of Greenland in the sunny months]]. //BMC Psychiatry//; 2009. )) which showed that suicide was much more common among Greenland residents in the summer than the winter months   * [[http://news.nationalgeographic.com/news/2009/05/090508-sunlight-suicide.html|Too Much Sunshine Spurs Suicides in Arctic, Study Says]] – review of a 2009 //BMC Psychiatry// article,((Björkstén. [[http://www.biomedcentral.com/content/pdf/1471-244x-9-20.pdf|Accentuation of suicides but not homicides with rising latitudes of Greenland in the sunny months]]. //BMC Psychiatry//; 2009. )) which showed that suicide was much more common among Greenland residents in the summer than the winter months
 +  * [[http://www.rt.com/news/russia-muslim-sect-satarov-213/|Children born and living without sunlight]] – In 2012, it was learned that 27 children had been living underground as members of a Muslim sect. Many had lived there for their entire lives and had never seen daylight. The conditions of these children was pronounced as "satisfactory" by pediatricians
  
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 ===== Notes and comments ===== ===== Notes and comments =====
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   * Legacy content   * Legacy content
     * http://www.marshallprotocol.com/view_topic.php?id=5035&forum_id=32&jump_to=75781#p75781 f242     * http://www.marshallprotocol.com/view_topic.php?id=5035&forum_id=32&jump_to=75781#p75781 f242
     * e72     * e72
     * f347     * f347
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 +<blockquote>Eye Contact Lens. 2011 Jul;37(4):176-84.
 +The mechanisms and consequences of ultraviolet-induced immunosuppression in the skin and eye.
 +Norval M.
 +Source
 +From Biomedical Sciences, University of Edinburgh, Scotland, United Kingdom.
 +Abstract
 +Ultraviolet radiation (UVR) of the skin results in immune suppression to antigens encountered shortly after the exposure. The pathways leading to the downregulation in immunity are complex, initiated by chromophores located at the surface of the skin and ending with the generation of immunosuppressive mediators and regulatory cells. Ultraviolet-induced immunosuppression can be considered not only as beneficial, such as in preventing chronic inflammatory responses and allergic and automimmune reactions, but it can also be detrimental, such as in the lack of control of skin tumors and infectious diseases. The eye is an immune privileged site through a wide variety of mechanisms that allow selected immune responses without causing inflammation. The role of UVR in altering immune responses in the eye is not clear and is discussed in relation to photokeratitis, herpetic stromal keratitis, and pterygium.
 +PMID: 21709488
 +
 +Little information is available currently as most epidemiological surveys that have monitored immune responses to vaccines do not consider solar UVR or the sun exposure of individuals, although several reports give some “hints” that UVR might be important. Thus, it has been reported that the efficacy of vaccination using Bacille Calmette Guerin (BCG)62 and poliovirus 63 increased as the latitude increased, and the efficacy increased if the vaccines for poliovirus, influenza A and B, and rubella 64 were administered in the winter months compared with administration in the summer months.
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 +62. Colditz GA, Brewer TF, Berkey CS, et al. Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. JAMA 1994;271:698-702. Bibliographic Links [Context Link]
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 +63. John TJ, Jayabal P. Oral polio vaccination of children in the tropics. I. The poor seroconversion rates and the absence of viral interference. Am J Epidemiol 1972;96:263-269. Bibliographic Links [Context Link]
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 +64. Linder N, Abudi Y, Abdulla W, et al. Effect of season of inoculation on immune response to rubella vaccine in children. J Trop Pediatr [published online ahead of print November 4, 2009]. doi:10.1093/tropej/fmp104. [Context Link]
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 +</blockquote>
  
 <blockquote>http://www.tgdaily.com/trendwatch-brief/57832-are-tanning-bed-addicts-like-junkies <blockquote>http://www.tgdaily.com/trendwatch-brief/57832-are-tanning-bed-addicts-like-junkies
home/othertreatments/sunshine.txt · Last modified: 09.14.2022 by 127.0.0.1
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