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home:pathogenesis:evidence_bacteria [06.15.2011] – paulalberthome:pathogenesis:evidence_bacteria [08.29.2012] – [Other evidence] paulalbert
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 According to the Marshall Pathogenesis, humans accumulate a plethora of pathogenic bacteria during their lifetimes, and it is the genetic mutations which result from active infection that play a major role in what is commonly thought of as “genetic susceptibility.” According to the Marshall Pathogenesis, humans accumulate a plethora of pathogenic bacteria during their lifetimes, and it is the genetic mutations which result from active infection that play a major role in what is commonly thought of as “genetic susceptibility.”
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 Besides the [[home:alternate:genetic_predisposition|absence of proof implicating human genes as the major causative factor]], there is a range of evidence - including strong epidemiological and compelling evolutionary evidence - suggesting that pathogens cause chronic diseases. Besides the [[home:alternate:genetic_predisposition|absence of proof implicating human genes as the major causative factor]], there is a range of evidence - including strong epidemiological and compelling evolutionary evidence - suggesting that pathogens cause chronic diseases.
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   * **Disease appearing in scars** – There are several case reports of sarcoidosis lesions forming within scars, which are especially susceptible to infection. That these granuloma often take long periods of time to be realized corresponds with the growth rate of the slow-growing chronic pathogens which the Marshall Pathogenesis implicates in chronic disease.(({{pubmed>long:17243430}})) According to one report, a patient developed sarcoid granuloma fully 50 years after his initial injury.(({{pubmed>long:19094856}})) Sorabee //et al// write(({{pubmed>long:15640432}})) that in addition to reactivation of scars obtained from previous wounds, scar sarcoidosis has been reported at the sites of previous intramuscular injections, blood donation venepuncture sites, scars of herpes zoster,(({{pubmed>long:10086879}})) sarcoidosis on ritual scarification,(({{pubmed>long:2917808}})) and at the sites of allergen extracts for desensitisation.(({{pubmed>long:1458650}}))    * **Disease appearing in scars** – There are several case reports of sarcoidosis lesions forming within scars, which are especially susceptible to infection. That these granuloma often take long periods of time to be realized corresponds with the growth rate of the slow-growing chronic pathogens which the Marshall Pathogenesis implicates in chronic disease.(({{pubmed>long:17243430}})) According to one report, a patient developed sarcoid granuloma fully 50 years after his initial injury.(({{pubmed>long:19094856}})) Sorabee //et al// write(({{pubmed>long:15640432}})) that in addition to reactivation of scars obtained from previous wounds, scar sarcoidosis has been reported at the sites of previous intramuscular injections, blood donation venepuncture sites, scars of herpes zoster,(({{pubmed>long:10086879}})) sarcoidosis on ritual scarification,(({{pubmed>long:2917808}})) and at the sites of allergen extracts for desensitisation.(({{pubmed>long:1458650}})) 
   * **Absence of an effect for most chemicals thought to be toxic** – In contrast to infectious agents, little evidence implicates typical doses of dietary chemicals as primary causes of human cancer. Paul Ewald, PhD has concluded that humans have evolved effective flexible enzymatic systems for degrading potentially carcinogenic chemicals.(({{pubmed>long:9255573}})) Even aflatoxins, which are one of the most carcinogenic of dietary constituents, may exert their negative effects largely in conjunction with viral infection.(({{pubmed>long:9270015}}))   * **Absence of an effect for most chemicals thought to be toxic** – In contrast to infectious agents, little evidence implicates typical doses of dietary chemicals as primary causes of human cancer. Paul Ewald, PhD has concluded that humans have evolved effective flexible enzymatic systems for degrading potentially carcinogenic chemicals.(({{pubmed>long:9255573}})) Even aflatoxins, which are one of the most carcinogenic of dietary constituents, may exert their negative effects largely in conjunction with viral infection.(({{pubmed>long:9270015}}))
 +  * **Difficulty distinguishing autoimmune disease from infectious disease** – Although they have identified a signature that distinguishes healthy individuals from sarcoidosis or tuberculosis patients, the biosignatures of both diseases are nevertheless very similar. According to the [[http://www.mpg.de/5771449/biosignatures_tuberculosis_sarcoidosis|Max Planck Institute]], it is almost impossible to distinguish between tuberculosis and sarcoidosis with just a single signature. A set of different biosignatures is better suited for distinguishing in a first step between diseased and healthy individuals and, in a further step, between the specific diseases.
  
  
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 ===== Notes and comments ===== ===== Notes and comments =====
-TECHEDIT+
  
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 +<blockquote>Pathogenicity is, in a sense, a highly skilled trade, and only a tiny minority of all the numberless tons of microbes on the earth has ever involved itself in it; most bacteria are busy with their own business, browsing and recycling the rest of life. Indeed, pathogenicity often seems to me a sort of biological accident in which signals are misdirected by the microbe or misinterpreted by the host.—Lewis Thomas, The Medusa and the Snail
 +
 +Sterile in health
 +
 +Characteristic of medically important bacteria's outer surface is a rigid cell wall containing peptidoglycan
 +--Review of Medical Microbiology and Immunology, 2008
 +
 +</blockquote>
 ===== References ===== ===== References =====
home/pathogenesis/evidence_bacteria.txt · Last modified: 09.14.2022 by 127.0.0.1
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