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home:pathogenesis:evidence_bacteria [03.26.2016] – [Evolutionary evidence] swopped order last 2 sentence sallieqhome:pathogenesis:evidence_bacteria [01.13.2020] – [Other evidence] sallieq
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   * **Treatment response** –  Whatever the chronic inflammatory condition, patients on the Marshall Protocol invariably experience the tell-tale immunopathological reaction, which can only be described as a bacterial die-off reaction. Though a number of other antibacterial treatments are ultimately less effective than the MP, patients also respond to these. Even high-dose antibiotics, which has a well-deserved reputation for being ineffective over the long term, do cause fundamental changes in disease symptoms of supposedly non-infectious diseases.   * **Treatment response** –  Whatever the chronic inflammatory condition, patients on the Marshall Protocol invariably experience the tell-tale immunopathological reaction, which can only be described as a bacterial die-off reaction. Though a number of other antibacterial treatments are ultimately less effective than the MP, patients also respond to these. Even high-dose antibiotics, which has a well-deserved reputation for being ineffective over the long term, do cause fundamental changes in disease symptoms of supposedly non-infectious diseases.
   * <html><span id="microbepopulations"></span></html>**Microbe populations** – Bacteria populations in patients with a given chronic disease have been shown to be different compared to those found in controls. Patients with autism have different bacteria in their gastrointestinal tract(({{pubmed>long:16157555}})) (({{pubmed>long:15459553}})) than do healthy infants as do those babies who later in life become obese or overweight.(({{pubmed>long:18326589}})) A team at Washington University has shown that the types of microbes in obese humans and mice are different when compared to those of normal weight; obese humans and mice have a 50% relative reduction in the abundance of Bacteroidetes and a proportional increase in Firmicutes.(({{pubmed>long:16033867}})) The team further showed that when the chronic disease obesity is decreased in humans through a low-calorie diet, the relative proportion of microbes changes.(({{pubmed>long:17183309}})) Finally, the group showed that obesity is transmissible: Ley et al took germ-free mice of normal weight, colonized their guts with an "obese microbiota", and found a significantly greater increase in total body fat than those mice colonized with a "lean microbiota."(({{pubmed>long:17183312}}))   * <html><span id="microbepopulations"></span></html>**Microbe populations** – Bacteria populations in patients with a given chronic disease have been shown to be different compared to those found in controls. Patients with autism have different bacteria in their gastrointestinal tract(({{pubmed>long:16157555}})) (({{pubmed>long:15459553}})) than do healthy infants as do those babies who later in life become obese or overweight.(({{pubmed>long:18326589}})) A team at Washington University has shown that the types of microbes in obese humans and mice are different when compared to those of normal weight; obese humans and mice have a 50% relative reduction in the abundance of Bacteroidetes and a proportional increase in Firmicutes.(({{pubmed>long:16033867}})) The team further showed that when the chronic disease obesity is decreased in humans through a low-calorie diet, the relative proportion of microbes changes.(({{pubmed>long:17183309}})) Finally, the group showed that obesity is transmissible: Ley et al took germ-free mice of normal weight, colonized their guts with an "obese microbiota", and found a significantly greater increase in total body fat than those mice colonized with a "lean microbiota."(({{pubmed>long:17183312}}))
-  * **[[home:diseases:co-infections|Co-infections]]** - Persistent co-infections, including fungi and viruses, are generally a sign of disease driven by infection. According to the Marshall Pathogenesis, these co-infections are able to proliferate because such chronic infections are able to slow the innate immune response. The presence of co-infections able to persist because the host is immunocompromised is common across all chronic disease types.  For example, a wide range of pathogens - at least have been found in the granuloma of sarcoidosis patients. According to Nicolson: "A large subset of ASD [autism spectrum disorder] patients shows evidence of bacterial and/or viral infections." (({{pubmed>long:17265454}}))  He reports that his team found conclusive evidence of Mycoplasma ssp., Chlamydia pneumoniae, and human herpes virus-6 coinfections in ASD patients. +  * **[[home:diseases:co-infections|Co-infections]]** - Persistent co-infections, including fungi and viruses, are generally a sign of disease driven by infection. According to the Marshall Pathogenesis, these co-infections are able to proliferate because such chronic infections are able to slow the innate immune response. The presence of co-infections able to persist because the host is immunocompromised is common across all chronic disease types.  For example, a wide range of pathogens - at least have been found in the granuloma of sarcoidosis patients. According to Nicolson: "A large subset of ASD [autism spectrum disorder] patients shows evidence of bacterial and/or viral infections." (({{pubmed>long:17265454}}))  He reports that his team found conclusive evidence of Mycoplasma ssp., Chlamydia pneumoniae, and human herpes virus-6 co-infections in ASD patients. 
 [{{ :home:pathogenesis:microbiota:gestationalage.gif|**Newer cultivation techniques have associated bacterial count in a pregnant woman's amniotic fluid with age at delivery.** This data strongly suggests a causative role for pathogenic bacteria in premature delivery. Source: [[http://www.ncbi.nlm.nih.gov/pubmed/18725970|DiGulio et al.]]}}] [{{ :home:pathogenesis:microbiota:gestationalage.gif|**Newer cultivation techniques have associated bacterial count in a pregnant woman's amniotic fluid with age at delivery.** This data strongly suggests a causative role for pathogenic bacteria in premature delivery. Source: [[http://www.ncbi.nlm.nih.gov/pubmed/18725970|DiGulio et al.]]}}]
   * **Failure of lifestyle interventions** – It has been widely hypothesized that lifestyle factors, including a poor diet and a lack of exercise, are the primary driver behind increased rates of chronic disease. For example, the World Health Organization [[http://www.who.int/dietphysicalactivity/publications/facts/obesity/en/|has termed]] "an obesity epidemic," but even the most ambitious obesity intervention programs, which have gone to great lengths to increase rates of exercise and improve eating habits of a population, have been failures. One 1999 $200,000 NIH-funded intervention, known as the Pathways program, was performed on two groups of children. Pathways involved a substantial increase in physical education programs, classes about nutrition, significant reduction in fat and calorie content of all school meals, and several other health related measures - and all as part of a randomized controlled trial, the gold standard in studies. The primary goal of the study was to reduce the rate of body fat in the intervention group, but after the three-year intervention the percent of body fat in both groups was essentially identical. The researchers were unable to explain the failure of their intervention.(({{pubmed>long:14594792}})) Other such trials for obesity have been equally unsuccessful.(({{pubmed>long:17028105}}))   * **Failure of lifestyle interventions** – It has been widely hypothesized that lifestyle factors, including a poor diet and a lack of exercise, are the primary driver behind increased rates of chronic disease. For example, the World Health Organization [[http://www.who.int/dietphysicalactivity/publications/facts/obesity/en/|has termed]] "an obesity epidemic," but even the most ambitious obesity intervention programs, which have gone to great lengths to increase rates of exercise and improve eating habits of a population, have been failures. One 1999 $200,000 NIH-funded intervention, known as the Pathways program, was performed on two groups of children. Pathways involved a substantial increase in physical education programs, classes about nutrition, significant reduction in fat and calorie content of all school meals, and several other health related measures - and all as part of a randomized controlled trial, the gold standard in studies. The primary goal of the study was to reduce the rate of body fat in the intervention group, but after the three-year intervention the percent of body fat in both groups was essentially identical. The researchers were unable to explain the failure of their intervention.(({{pubmed>long:14594792}})) Other such trials for obesity have been equally unsuccessful.(({{pubmed>long:17028105}}))
home/pathogenesis/evidence_bacteria.txt · Last modified: 09.14.2022 by 127.0.0.1
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