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home:pathogenesis:kochs_postulates [08.08.2011] – [Still valid?] paulalbert | home:pathogenesis:kochs_postulates [09.14.2022] (current) – external edit 127.0.0.1 | ||
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According to T.D. Brock at the American Society of Microbiology, | According to T.D. Brock at the American Society of Microbiology, | ||
- | In 1932, Razumov noted a large discrepancy between the viable plate count and total direct microscopic count of bacteria taken from aquatic habitats, | + | In 1932, Razumov noted a large discrepancy between the viable plate count and total direct microscopic count of bacteria taken from aquatic habitats, |
The faithful adherence to Koch's ideas about disease has led researchers to overestimate their comprehension of how pathogens cause disease. | The faithful adherence to Koch's ideas about disease has led researchers to overestimate their comprehension of how pathogens cause disease. | ||
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For most of the twentieth century, the predominant feeling about the treatment, control and prevention of infectious diseases was optimism. | For most of the twentieth century, the predominant feeling about the treatment, control and prevention of infectious diseases was optimism. | ||
- | **// | + | **// |
</ | </ | ||
In 1931, Henry Sigerist wrote, "Most of the infectious diseases ... have now yielded up their secrets.... Many illnesses ... had been completely exterminated; | In 1931, Henry Sigerist wrote, "Most of the infectious diseases ... have now yielded up their secrets.... Many illnesses ... had been completely exterminated; | ||
- | < | + | < |
- | With " | + | With " |
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< | < | ||
- | //**Robert P. Hanson**// (({{pubmed> | + | //**Robert P. Hanson**// (({{pmid> |
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Another problem with the postulates - and perhaps its most significant liability - is that the rules fail to successfully account for [[home: | Another problem with the postulates - and perhaps its most significant liability - is that the rules fail to successfully account for [[home: | ||
===== Rethinking Koch ===== | ===== Rethinking Koch ===== | ||
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+ | < | ||
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+ | //**David N. Fredricks and David A. Relman**// | ||
+ | </ | ||
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Koch's contributions were substantial, | Koch's contributions were substantial, | ||
- | The blind adherence to Koch's postulates precludes a more nuanced understanding of disease: it is in fact a group of genetically indistinct organisms, a [[home: | + | The blind adherence to Koch's postulates precludes a more nuanced understanding of disease: it is in fact a group of genetically indistinct organisms, a [[home: |
+ | |||
+ | In a 2005 //Lancet// paper, Brogden //et al.// point to the existence of dozens of polymicrobial diseases, caused by combinations of viruses, bacteria, fungi, and parasites.(({{pmid> | ||
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{{tag> Pathogenesis Study_Design}} | {{tag> Pathogenesis Study_Design}} | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
- | TECHEDIT | + | |
* Legacy content | * Legacy content | ||
- | * http:// | + | * https:// |
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L. Garrett. 2000. Betrayal of Trust: The Collapse of Global Public Health. New York. Hyperion: 474. | L. Garrett. 2000. Betrayal of Trust: The Collapse of Global Public Health. New York. Hyperion: 474. | ||
- | B. Gewen. ‘The Great Influenza’ and ‘Microbial Threats to Health’: Virus Alert. The New York Times March 14, 2004, available at: http:// | + | B. Gewen. ‘The Great Influenza’ and ‘Microbial Threats to Health’: Virus Alert. The New York Times March 14, 2004, available at: https:// |
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+ | ===== References =====</ | ||
- | ===== References ===== |