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home:pathogenesis:kochs_postulates [08.28.2012]
paulalbert [Rethinking Koch]
home:pathogenesis:kochs_postulates [08.28.2012] (current)
paulalbert [Rethinking Koch]
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 The blind adherence to Koch's postulates precludes a more nuanced understanding of disease: it is in fact a group of genetically indistinct organisms, a [[home:​pathogenesis:​microbiota|metagenomic microbiota]],​ which may cause and drive chronic disease. ​ The blind adherence to Koch's postulates precludes a more nuanced understanding of disease: it is in fact a group of genetically indistinct organisms, a [[home:​pathogenesis:​microbiota|metagenomic microbiota]],​ which may cause and drive chronic disease. ​
  
-In a 2005 //Lancet// paper, Brogden //et al.// point to the existence of dozens of polymicrobial diseases, caused by combinations of viruses, bacteria, fungi, and parasites.(({{pubmed>​long:​15652608}})) In these infections, the presence of one micro-organism generates a niche for other pathogenic micro-organisms to colonise, one micro-organism predisposes the host to colonisation by other micro-organisms,​ or two or more non-pathogenic micro-organisms together cause disease.+In a 2005 //Lancet// paper, Brogden //et al.// point to the existence of dozens of polymicrobial diseases, caused by combinations of viruses, bacteria, fungi, and parasites.(({{pubmed>​long:​15652608}})) In these infections, the presence of one micro-organism generates a niche for other pathogenic micro-organisms to colonise, one micro-organism predisposes the host to colonisation by other micro-organisms,​ or two or more non-pathogenic micro-organisms together cause disease. This topic is discussed further in the article [[home:​pathogenesis:​successive_infection|Successive infection and variability in disease]].
  
  
home/pathogenesis/kochs_postulates.txt · Last modified: 08.28.2012 by paulalbert
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