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home:pathogenesis:microbiota:interaction [09.09.2012] – paulalbert | home:pathogenesis:microbiota:interaction [09.23.2012] – [Notes and comments] paulalbert | ||
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====== Effects of bacteria on their human host ====== | ====== Effects of bacteria on their human host ====== | ||
- | Manipulation | + | |
+ | The genomes and the respective proteomes of microbes in the body frequently interact with those expressed by their human hosts. This is a key part of what is know as the interactome. The " | ||
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[{{ : | [{{ : | ||
+ | The genomes and the respective proteomes of microbes in the body frequently interact with those expressed by their human hosts. This is a key part of what is know as the interactome. The " | ||
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+ | ==== Viruses ==== | ||
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+ | In a 2007 analysis of sequence similarity between hepatitis C virus (HCV) and humans Kusalik //et al.// found that pentamers from HCV polyprotein have a widespread and high level of similarity to a large number of human proteins (19,605 human proteins, that is 57.6% of the human proteome).(({{pubmed> | ||
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+ | A 2008 study examined thirty viral proteomes were examined for amino acid sequence similarity to the human proteome (as well as a control of 30 sets of human proteins).(({{pubmed> | ||
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+ | ==== Bacteria ==== | ||
+ | Work on bacterial proteomes, while more recent, has also been illuminating. Trost //et al.// studied in 2010 forty bacterial proteomes for amino acid sequence similarity to the human proteome.(({{pubmed> | ||
+ | Expanding on this work, Trost //et al.// performed a pentapeptide and hexapeptide analyses of sequence similarities between bacterial and human DNA.(({{pubmed> | ||
+ | Surveys of protein-protein interactions have also been completed for // | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
+ | ===== References ===== |