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home:pathogenesis:microbiota:interaction [09.09.2012] – paulalbert | home:pathogenesis:microbiota:interaction [03.20.2020] – [Viruses] sallieq | ||
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- | ====== Effects of bacteria on their human host ====== | + | ====== Effects of bacteria |
- | Manipulation | + | |
+ | The genomes and the respective proteomes of microbes in the body frequently interact with those expressed by their human hosts. This is a key part of what is know as the interactome. The " | ||
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- | The genomes and the respective proteomes of microbes in the body frequently interact with those expressed by their human hosts. This is a key part of what is know as the interactome. The co-occurrence of protein-coding genes between microbes and humans speaks to the survival advantage of such homology, and the extent to which sequence overlap may play a key role in disease. | + | The genomes and the respective proteomes of microbes in the body frequently interact with those expressed by their human hosts. This is a key part of what is know as the interactome. The " |
- | Work to understand extent of protein-protein interactions between microbe and man is in its early stages, but there are some indications of its full extent. Several studies out of University of Saskatchewan have been particularly provocative. | + | ==== Viruses ==== |
+ | In a 2007 analysis of sequence similarity between hepatitis C virus (HCV) and humans Kusalik //et al.// found that pentamers from HCV polyprotein have a widespread and high level of similarity to a large number of human proteins (19,605 human proteins, that is 57.6% of the human proteome).(({{pubmed> | ||
+ | A 2008 study examined thirty viral proteomes were examined for amino acid sequence similarity to the human proteome (as well as a control of 30 sets of human proteins).(({{pubmed> | ||
+ | Several teams researching coronavirus [[https:// | ||
- | ==== Sequence homology ==== | + | [[https:// |
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+ | [[http:// | ||
+ | ==== Bacteria ==== | ||
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+ | Work on bacterial proteomes, while more recent, has also been illuminating. Trost //et al.// studied in 2010 forty bacterial proteomes for amino acid sequence similarity to the human proteome.(({{pubmed> | ||
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+ | Expanding on this work, Trost //et al.// performed a pentapeptide and hexapeptide analyses of sequence similarities between bacterial and human DNA.(({{pubmed> | ||
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+ | Surveys of protein-protein interactions have also been completed for // | ||
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The highly variable range of human genetic mutations induced by bacteria have been identified with some success by researchers with the Human Genome Project. Rather than serving as markers of particular diseases, such mutations generally mark the presence of those pathogens capable of affecting DNA transcription and translation in the nucleus. | The highly variable range of human genetic mutations induced by bacteria have been identified with some success by researchers with the Human Genome Project. Rather than serving as markers of particular diseases, such mutations generally mark the presence of those pathogens capable of affecting DNA transcription and translation in the nucleus. | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
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+ | ===== References ===== |