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home:pathogenesis:microbiota:interaction [09.09.2012] – paulalbert | home:pathogenesis:microbiota:interaction [05.23.2020] – [Coronavirus] sallieq | ||
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- | ====== Effects of bacteria on their human host ====== | + | ====== Effects of bacteria |
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- | The genomes and the respective proteomes of microbes in the body frequently interact with those expressed by their human hosts. This is a key part of what is know as the interactome. The " | ||
+ | The genomes and the respective proteomes of microbes in the body frequently interact with those expressed by their human hosts. This is a key part of what is know as the interactome. The " | ||
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==== Viruses ==== | ==== Viruses ==== | ||
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In a 2007 analysis of sequence similarity between hepatitis C virus (HCV) and humans Kusalik //et al.// found that pentamers from HCV polyprotein have a widespread and high level of similarity to a large number of human proteins (19,605 human proteins, that is 57.6% of the human proteome).(({{pubmed> | In a 2007 analysis of sequence similarity between hepatitis C virus (HCV) and humans Kusalik //et al.// found that pentamers from HCV polyprotein have a widespread and high level of similarity to a large number of human proteins (19,605 human proteins, that is 57.6% of the human proteome).(({{pubmed> | ||
A 2008 study examined thirty viral proteomes were examined for amino acid sequence similarity to the human proteome (as well as a control of 30 sets of human proteins).(({{pubmed> | A 2008 study examined thirty viral proteomes were examined for amino acid sequence similarity to the human proteome (as well as a control of 30 sets of human proteins).(({{pubmed> | ||
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+ | ==== Coronavirus ==== | ||
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+ | Several teams researching coronavirus [[https:// | ||
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+ | How does social distancing work? [[https:// | ||
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+ | current evidence(({{pubmed> | ||
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+ | chloroquine (({{pubmed> | ||
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+ | neuroinvasive potential(({{pubmed> | ||
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+ | Unique epidemiological and clinical features(({{pubmed> | ||
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+ | Presumed Asymptomatic Carrier Transmission(({{pubmed> | ||
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+ | Discovering drugs(({{pubmed> | ||
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+ | breakthrough(({{pubmed> | ||
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+ | What we know so far(({{pubmed> | ||
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+ | It seems [[https:// | ||
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+ | February 2020 The multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia developed this expert consensus after extensive discussion. It recommended chloroquine phosphate tablet, 500mg twice per day for 10 days for patients diagnosed as mild, moderate and severe cases of novel coronavirus pneumonia and without contraindications to chloroquine. (({{pubmed> | ||
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+ | **May 2020** Results of extensive study of [[https:// | ||
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+ | 96 032 patients (mean age 53·8 years, 46·3% women) with COVID-19 were hospitalised during the study period and met the inclusion criteria. | ||
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+ | Data from 671 hospitals in six continents | ||
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+ | Patients who received one of the treatments of interest within 48 h of diagnosis were included in one of four treatment groups (chloroquine alone, chloroquine with a macrolide, hydroxychloroquine alone, or hydroxychloroquine with a macrolide), and patients who received none of these treatments formed the control group. Patients for whom one of the treatments of interest was initiated more than 48 h after diagnosis or while they were on mechanical ventilation, | ||
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+ | After controlling for multiple confounding factors (age, sex, race or ethnicity, body-mass index, underlying cardiovascular disease and its risk factors, diabetes, underlying lung disease, smoking, immunosuppressed condition, and baseline disease severity), | ||
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+ | The main outcomes of interest were in-hospital mortality and the occurrence of de-novo ventricular arrhythmias (non-sustained or sustained ventricular tachycardia or ventricular fibrillation). | ||
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+ | Compared with the control group (0·3%), hydroxychloroquine (6·1%; 2·369, 1·935–2·900), | ||
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+ | When compared with mortality in the control group (9·3%), hydroxychloroquine (18·0%; hazard ratio 1·335, 95% CI 1·223–1·457), | ||
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+ | [[https:// | ||
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+ | Drug used for Ebola is being tested on 600 participants in a study started March 15, 2020 and expected to complete in May 2020 [[https:// | ||
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+ | |Laboratory experiment shows Ivermectin can kill the virus within 48 hours in cell culture]] | ||
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==== Bacteria ==== | ==== Bacteria ==== | ||
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Expanding on this work, Trost //et al.// performed a pentapeptide and hexapeptide analyses of sequence similarities between bacterial and human DNA.(({{pubmed> | Expanding on this work, Trost //et al.// performed a pentapeptide and hexapeptide analyses of sequence similarities between bacterial and human DNA.(({{pubmed> | ||
+ | Surveys of protein-protein interactions have also been completed for // | ||
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The highly variable range of human genetic mutations induced by bacteria have been identified with some success by researchers with the Human Genome Project. Rather than serving as markers of particular diseases, such mutations generally mark the presence of those pathogens capable of affecting DNA transcription and translation in the nucleus. | The highly variable range of human genetic mutations induced by bacteria have been identified with some success by researchers with the Human Genome Project. Rather than serving as markers of particular diseases, such mutations generally mark the presence of those pathogens capable of affecting DNA transcription and translation in the nucleus. | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
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+ | ===== References ===== |