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home:pathogenesis:microbiota:interaction [09.09.2012] – [Bacteria] paulalbert | home:pathogenesis:microbiota:interaction [04.26.2020] – [Effects of bacteria and viruses on their human host] sallieq | ||
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- | ====== Effects of bacteria on their human host ====== | + | ====== Effects of bacteria |
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- | The genomes and the respective proteomes of microbes in the body frequently interact with those expressed by their human hosts. This is a key part of what is know as the interactome. The " | ||
+ | The genomes and the respective proteomes of microbes in the body frequently interact with those expressed by their human hosts. This is a key part of what is know as the interactome. The " | ||
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==== Viruses ==== | ==== Viruses ==== | ||
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In a 2007 analysis of sequence similarity between hepatitis C virus (HCV) and humans Kusalik //et al.// found that pentamers from HCV polyprotein have a widespread and high level of similarity to a large number of human proteins (19,605 human proteins, that is 57.6% of the human proteome).(({{pubmed> | In a 2007 analysis of sequence similarity between hepatitis C virus (HCV) and humans Kusalik //et al.// found that pentamers from HCV polyprotein have a widespread and high level of similarity to a large number of human proteins (19,605 human proteins, that is 57.6% of the human proteome).(({{pubmed> | ||
A 2008 study examined thirty viral proteomes were examined for amino acid sequence similarity to the human proteome (as well as a control of 30 sets of human proteins).(({{pubmed> | A 2008 study examined thirty viral proteomes were examined for amino acid sequence similarity to the human proteome (as well as a control of 30 sets of human proteins).(({{pubmed> | ||
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+ | Several teams researching coronavirus [[https:// | ||
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+ | How does social distancing work? [[https:// | ||
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+ | current evidence(({{pubmed> | ||
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+ | chloroquine (({{pubmed> | ||
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+ | Unique epidemiological and clinical features(({{pubmed> | ||
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+ | Presumed Asymptomatic Carrier Transmission(({{pubmed> | ||
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+ | Discovering drugs(({{pubmed> | ||
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+ | breakthrough(({{pubmed> | ||
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+ | What we know so far(({{pubmed> | ||
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+ | It seems [[https:// | ||
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+ | February 2020 The multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia developed this expert consensus after extensive discussion. It recommended chloroquine phosphate tablet, 500mg twice per day for 10 days for patients diagnosed as mild, moderate and severe cases of novel coronavirus pneumonia and without contraindications to chloroquine. (({{pubmed> | ||
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+ | Drug used for Ebola is being tested on 600 participants in a study started March 15, 2020 and expected to complete in May 2020 [[https:// | ||
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==== Bacteria ==== | ==== Bacteria ==== | ||
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The highly variable range of human genetic mutations induced by bacteria have been identified with some success by researchers with the Human Genome Project. Rather than serving as markers of particular diseases, such mutations generally mark the presence of those pathogens capable of affecting DNA transcription and translation in the nucleus. | The highly variable range of human genetic mutations induced by bacteria have been identified with some success by researchers with the Human Genome Project. Rather than serving as markers of particular diseases, such mutations generally mark the presence of those pathogens capable of affecting DNA transcription and translation in the nucleus. | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
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+ | ===== References ===== |