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home:pathogenesis:microbiota [01.12.2020] – [Insights from new molecular methods for identifying bacteria] sallieq | home:pathogenesis:microbiota [01.12.2020] – [Role of Vitamin D Receptor] sallieq | ||
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* **Microbial variability may be relatively unrelated to food intake** – While Dumas has shown that there are significant inter-regional differences in metabolites, | * **Microbial variability may be relatively unrelated to food intake** – While Dumas has shown that there are significant inter-regional differences in metabolites, | ||
* **Many bacteria cannot be cultured using traditional cultivation techniques** – Using PCR, Fierer' | * **Many bacteria cannot be cultured using traditional cultivation techniques** – Using PCR, Fierer' | ||
- | * **Some microbes need very few genes to persist** – The genome of the microsporidia // | + | * **Some microbes need very few genes to persist** – The genome of the microsporidia // |
* **A number of bacteria never thought to exist in man, do, and in large numbers.** – A 2007 study, for example, found [[http:// | * **A number of bacteria never thought to exist in man, do, and in large numbers.** – A 2007 study, for example, found [[http:// | ||
* **At least in fruit flies, gut microbes can alter mating preferences** – In a [[http:// | * **At least in fruit flies, gut microbes can alter mating preferences** – In a [[http:// | ||
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- | At least some of the bacteria which cause disease are intracellular. These microbes take hold progressively through a process called successive infection. Chronic forms of bacteria are able to survive and reproduce by generating substances which block and turn off the Vitamin D Receptor, a key nuclear receptor which controls the innate immune response. So logical and powerful is this survival mechanism that it seems very likely that this is the primary mode by which chronic pathogenic forms persist. It simply makes too much evolutionary sense for pathogens | + | At least some of the bacteria which cause disease are intracellular. These microbes take hold progressively through a process called successive infection. Chronic forms of bacteria are able to survive and reproduce by generating substances which block and turn off the Vitamin D Receptor, a key nuclear receptor which controls the innate immune response. So logical and powerful is this survival mechanism that it seems very likely that this is the primary mode by which chronic pathogenic forms persist. It simply makes evolutionary sense for pathogens to take full advantage of a receptor, which according to one recent study, transcribes hundreds of genes.(({{pubmed> |