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home:pathogenesis:microbiota [01.12.2020]
sallieq [Insights from new molecular methods for identifying bacteria]
home:pathogenesis:microbiota [01.12.2020] (current)
sallieq [Role of Vitamin D Receptor]
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 <​mainarticle> ​ [[home:​pathogenesis:​vitamind:​metabolism|Metabolism of vitamin D and the Vitamin D Receptor]]</​article>​ <​mainarticle> ​ [[home:​pathogenesis:​vitamind:​metabolism|Metabolism of vitamin D and the Vitamin D Receptor]]</​article>​
  
-At least some of the bacteria which cause disease are intracellular. These microbes take hold progressively through a process called successive infection. Chronic forms of bacteria are able to survive and reproduce by generating substances which block and turn off the Vitamin D Receptor, a key nuclear receptor which controls the innate immune response. So logical and powerful is this survival mechanism that it seems very likely that this is the primary mode by which chronic pathogenic forms persist. It simply makes too much evolutionary sense for pathogens ​not to take full advantage of a receptor, which according to one recent study, transcribes hundreds of genes.(({{pubmed>​long:​20736230}}))+At least some of the bacteria which cause disease are intracellular. These microbes take hold progressively through a process called successive infection. Chronic forms of bacteria are able to survive and reproduce by generating substances which block and turn off the Vitamin D Receptor, a key nuclear receptor which controls the innate immune response. So logical and powerful is this survival mechanism that it seems very likely that this is the primary mode by which chronic pathogenic forms persist. It simply makes evolutionary sense for pathogens to take full advantage of a receptor, which according to one recent study, transcribes hundreds of genes.(({{pubmed>​long:​20736230}}))
  
  
home/pathogenesis/microbiota.txt · Last modified: 01.12.2020 by sallieq
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