You are here: Welcome to the MPKB » Welcome to the MPKB » Science behind Pathogenesis » Transmission of bacteria and onset of chronic disease
Home

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision		Previous revision
Next revisionBoth sides next revision
home:pathogenesis:transmission [02.13.2019] – [Notes and comments] sallieqhome:pathogenesis:transmission [01.12.2020] – [Metabolic evidence for transmission of bacteria] sallieq
Line 7: Line 7:
 Those who use or consume any of the foods, drugs, and supplements which exert [[http://mpkb.org/doku.php/tag:immunosuppressants?do=showtag&tag=immunosuppressants|immunosuppressive]] effects are also uniquely predisposed to acquire new bacteria and permit them to reproduce. These substances include: immunosuppressants, beta-lactam antibiotics such as penicillin, [[home:food:vitamind|high levels of vitamin D]], and corticosteroids. Those who use or consume any of the foods, drugs, and supplements which exert [[http://mpkb.org/doku.php/tag:immunosuppressants?do=showtag&tag=immunosuppressants|immunosuppressive]] effects are also uniquely predisposed to acquire new bacteria and permit them to reproduce. These substances include: immunosuppressants, beta-lactam antibiotics such as penicillin, [[home:food:vitamind|high levels of vitamin D]], and corticosteroids.
  
-The acquisition of new bacteria is only one factor in the when and why chronic diseases strike. Bacteria are capable of rapidly changing their genetic structure – and can become more pathogenic and harder to kill with traditional therapies – through processes like [[home:pathogenesis:horizontal_gene|horizontal gene transfer]]. Also, bacteria are allowed to proliferate because of a disabled immune response, for which they themselves are at least partially responsible.+The acquisition of new bacteria is only one factor in the when and why chronic diseases strike. Bacteria are capable of rapidly changing their genetic structure – and can become more pathogenic and harder to kill with traditional therapies – through processes like [[home:pathogenesis:horizontal_gene|horizontal gene transfer]]. Also, bacteria are allowed to proliferate because of a weak immune response, for which they themselves are at least partially responsible.
  
 ===== Vectors for transmission ===== ===== Vectors for transmission =====
Line 178: Line 178:
 [[home:special:tissue_donation|Donation of blood, bone marrow, organs or other tissues]] transmits pathogens between donor and recipient - even, in the case of blood donation, when there is an attempt to filter blood. At an average of around 0.01 microns in diameter, L-form bacteria are small enough to pass through even the finest of filters.((Mattman, L. 2000. Cell Wall Deficient Forms: Stealth Pathogens. CRC Press. Boca Raton, FL.))  [[home:special:tissue_donation|Donation of blood, bone marrow, organs or other tissues]] transmits pathogens between donor and recipient - even, in the case of blood donation, when there is an attempt to filter blood. At an average of around 0.01 microns in diameter, L-form bacteria are small enough to pass through even the finest of filters.((Mattman, L. 2000. Cell Wall Deficient Forms: Stealth Pathogens. CRC Press. Boca Raton, FL.)) 
  
-Organs and tissue from sarcoidosis patients have been known to cause sarcoidosis in the transplanted recipients.(({{pubmed>long:12002380}})) According to one study, patients who receive a donor organ from a sarcoidosis patient develop the disease, and clean organs transplanted into sarcoidosis patients become infected.(({{pubmed>long:12172448}})) This is proof that the bacterial pathogens can be transferred and trigger the same abnormal immune system response in susceptible people.+Organs and tissue from sarcoidosis patients have been known to cause sarcoidosis in the transplant recipients.(({{pubmed>long:12002380}})) According to one study, patients who receive a donor organ from a sarcoidosis patient develop the disease, and clean organs transplanted into sarcoidosis patients become infected.(({{pubmed>long:12172448}})) This is proof that the bacterial pathogens can be transferred and trigger the same abnormal immune system response in susceptible people.
 ==== Insect bites and other infectious triggers ==== ==== Insect bites and other infectious triggers ====
  
Line 215: Line 215:
 Interestingly, people who recently moved between regions began to take on the metabolic profile of that region. One particular artifact is that there are a number of violet numbers in the American group. These represent five Japanese men and women who recently moved to America. When they did that, their metabalomes suddenly took on the American characteristics rather than their native Japanese characteristics.  Interestingly, people who recently moved between regions began to take on the metabolic profile of that region. One particular artifact is that there are a number of violet numbers in the American group. These represent five Japanese men and women who recently moved to America. When they did that, their metabalomes suddenly took on the American characteristics rather than their native Japanese characteristics. 
  
-At the very least, Dumas's work shows that the makeup of the "metabolome" owes more to environmental factors than genetic ones. To this end, a 2004 study by Wirth showed that two human ethnic groups based in India, which could not be distinguished on the basis of human DNA markers, could be distinguished based on their patterns of //H. pylori// variation.(({{pubmed>long:15051885}})) +Dumas's work shows that the makeup of the "metabolome" owes more to environmental factors than genetic ones. To this end, a 2004 study by Wirth showed that two human ethnic groups based in India, which could not be distinguished on the basis of human DNA markers, could be distinguished based on their patterns of //H. pylori// variation.(({{pubmed>long:15051885}})) 
  
  
home/pathogenesis/transmission.txt · Last modified: 09.14.2022 by 127.0.0.1
© 2015, Autoimmunity Research Foundation. All Rights Reserved.