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home:pathogenesis:transmission [01.12.2020] – [Transmission of bacteria and onset of chronic disease] sallieqhome:pathogenesis:transmission [01.12.2020] – [Disabled immune response increases susceptibility to acute infections] sallieq
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 [[home:special:tissue_donation|Donation of blood, bone marrow, organs or other tissues]] transmits pathogens between donor and recipient - even, in the case of blood donation, when there is an attempt to filter blood. At an average of around 0.01 microns in diameter, L-form bacteria are small enough to pass through even the finest of filters.((Mattman, L. 2000. Cell Wall Deficient Forms: Stealth Pathogens. CRC Press. Boca Raton, FL.))  [[home:special:tissue_donation|Donation of blood, bone marrow, organs or other tissues]] transmits pathogens between donor and recipient - even, in the case of blood donation, when there is an attempt to filter blood. At an average of around 0.01 microns in diameter, L-form bacteria are small enough to pass through even the finest of filters.((Mattman, L. 2000. Cell Wall Deficient Forms: Stealth Pathogens. CRC Press. Boca Raton, FL.)) 
  
-Organs and tissue from sarcoidosis patients have been known to cause sarcoidosis in the transplanted recipients.(({{pubmed>long:12002380}})) According to one study, patients who receive a donor organ from a sarcoidosis patient develop the disease, and clean organs transplanted into sarcoidosis patients become infected.(({{pubmed>long:12172448}})) This is proof that the bacterial pathogens can be transferred and trigger the same abnormal immune system response in susceptible people.+Organs and tissue from sarcoidosis patients have been known to cause sarcoidosis in the transplant recipients.(({{pubmed>long:12002380}})) According to one study, patients who receive a donor organ from a sarcoidosis patient develop the disease, and clean organs transplanted into sarcoidosis patients become infected.(({{pubmed>long:12172448}})) This is proof that the bacterial pathogens can be transferred and trigger the same abnormal immune system response in susceptible people.
 ==== Insect bites and other infectious triggers ==== ==== Insect bites and other infectious triggers ====
  
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 Interestingly, people who recently moved between regions began to take on the metabolic profile of that region. One particular artifact is that there are a number of violet numbers in the American group. These represent five Japanese men and women who recently moved to America. When they did that, their metabalomes suddenly took on the American characteristics rather than their native Japanese characteristics.  Interestingly, people who recently moved between regions began to take on the metabolic profile of that region. One particular artifact is that there are a number of violet numbers in the American group. These represent five Japanese men and women who recently moved to America. When they did that, their metabalomes suddenly took on the American characteristics rather than their native Japanese characteristics. 
  
-At the very least, Dumas's work shows that the makeup of the "metabolome" owes more to environmental factors than genetic ones. To this end, a 2004 study by Wirth showed that two human ethnic groups based in India, which could not be distinguished on the basis of human DNA markers, could be distinguished based on their patterns of //H. pylori// variation.(({{pubmed>long:15051885}})) +Dumas's work shows that the makeup of the "metabolome" owes more to environmental factors than genetic ones. To this end, a 2004 study by Wirth showed that two human ethnic groups based in India, which could not be distinguished on the basis of human DNA markers, could be distinguished based on their patterns of //H. pylori// variation.(({{pubmed>long:15051885}})) 
  
  
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 According to the Marshall Pathogenesis, "frailty" could just as easily refer to the strength of immune response. It is the absence of a robust immune response which is the primary contributing determinant in whether someone gets sick with chronic illness or someone remains healthy. According to the Marshall Pathogenesis, "frailty" could just as easily refer to the strength of immune response. It is the absence of a robust immune response which is the primary contributing determinant in whether someone gets sick with chronic illness or someone remains healthy.
  
-Bacterial pathogens themselves can make a human host more hospitable for growth and reproduction by secreting substances like the sulfonolipid capnine, which bind and block the Vitamin D Receptor, a nuclear receptor that controls the innate immune response. Over time, bacteria succeed in suppressing the immune response through a gradual process known as [[home:pathogenesis:successive_infection#successive_infection|successive infection]]. In the absence of intervention, successive infection is something of an inevitability as everyone who lives long enough take on the aches, pains, memory loss, and other symptoms that are the hallmark of chronic disease.+Bacterial pathogens themselves can make a human host more hospitable to their growth and reproduction by secreting substances like the sulfonolipid capnine, which bind and block the Vitamin D Receptor, a nuclear receptor that controls the innate immune response. Over time, bacteria succeed in suppressing the immune response through a gradual process known as [[home:pathogenesis:successive_infection#successive_infection|successive infection]]. In the absence of intervention, successive infection is something of an inevitability as everyone who lives long enough will take on the aches, pains, memory loss, and other symptoms that are the hallmark of chronic disease.
  
 Bacteria are allowed to further proliferate when a person consumes any number of [[http://mpkb.org/doku.php/tag:immunosuppressants?do=showtag&tag=immunosuppressants|immunosuppressive]] foods, drugs, supplements and other substances. These substances include: immunosuppressants, [[home:othertreatments:antidepressants#beta-lactam_antibiotics|beta-lactam antibiotics]] such as penicillin, [[home:othertreatments::corticosteroids|corticosteroids]], and foods and supplements containing [[home:food:vitamind|high levels of vitamin D]]. The consumption of such substances is at historical levels and may be largely responsible for the recent spike in chronic disease incidence. Bacteria are allowed to further proliferate when a person consumes any number of [[http://mpkb.org/doku.php/tag:immunosuppressants?do=showtag&tag=immunosuppressants|immunosuppressive]] foods, drugs, supplements and other substances. These substances include: immunosuppressants, [[home:othertreatments:antidepressants#beta-lactam_antibiotics|beta-lactam antibiotics]] such as penicillin, [[home:othertreatments::corticosteroids|corticosteroids]], and foods and supplements containing [[home:food:vitamind|high levels of vitamin D]]. The consumption of such substances is at historical levels and may be largely responsible for the recent spike in chronic disease incidence.
home/pathogenesis/transmission.txt · Last modified: 09.14.2022 by 127.0.0.1
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