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home:pathogenesis:transmission [01.12.2020] – [Metabolic evidence for transmission of bacteria] sallieq | home:pathogenesis:transmission [09.14.2022] (current) – external edit 127.0.0.1 | ||
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Pathogens that grow slowly and accumulate over the course of decades may play a strong role in many chronic diseases. These bacteria are transmitted in a variety of ways: mother to fetus, sperm to embryo, and among families and social groups. Particular patient groups without the benefit of a fully functioning immune system, specifically newborn infants, people who already have illnesses, and the elderly, are uniquely susceptible to pathogens. | Pathogens that grow slowly and accumulate over the course of decades may play a strong role in many chronic diseases. These bacteria are transmitted in a variety of ways: mother to fetus, sperm to embryo, and among families and social groups. Particular patient groups without the benefit of a fully functioning immune system, specifically newborn infants, people who already have illnesses, and the elderly, are uniquely susceptible to pathogens. | ||
- | Those who use or consume any of the foods, drugs, and supplements which exert [[http:// | + | Those who use or consume any of the foods, drugs, and supplements which exert [[https:// |
The acquisition of new bacteria is only one factor in the when and why chronic diseases strike. Bacteria are capable of rapidly changing their genetic structure – and can become more pathogenic and harder to kill with traditional therapies – through processes like [[home: | The acquisition of new bacteria is only one factor in the when and why chronic diseases strike. Bacteria are capable of rapidly changing their genetic structure – and can become more pathogenic and harder to kill with traditional therapies – through processes like [[home: | ||
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===== Vectors for transmission ===== | ===== Vectors for transmission ===== | ||
- | It is commonly agreed upon that acute infections such as gonorrhea, influenza, and the common cold are transmitted via bodily fluids and in some cases via physical contact and breathing. Evidence is accumulating that chronic pathogens can and are transferred between people in ways previously unimagined and that these pathogens contribute to onset of chronic disease. For example, Weyermann //et al.// has shown that infected siblings, mothers, and fathers are all major sources for // | + | It is commonly agreed upon that acute infections such as gonorrhea, influenza, and the common cold are transmitted via bodily fluids and in some cases via physical contact and breathing. Evidence is accumulating that chronic pathogens can and are transferred between people in ways previously unimagined and that these pathogens contribute to onset of chronic disease. For example, Weyermann //et al.// has shown that infected siblings, mothers, and fathers are all major sources for // |
==== From father to child via sperm ==== | ==== From father to child via sperm ==== | ||
- | Research indicates that pathogens are able to survive in sperm, so a father can pass these bacteria to his child at the moment of conception.(({{pubmed> | + | Research indicates that pathogens are able to survive in sperm, so a father can pass these bacteria to his child at the moment of conception.(({{pmid> |
==== From mother to fetus during pregnancy ==== | ==== From mother to fetus during pregnancy ==== | ||
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< | < | ||
- | //**Y.W. Han**// (({{pubmed> | + | //**Y.W. Han**// (({{pmid> |
</ | </ | ||
- | A mother' | + | A mother' |
Evidence is also growing that certain bacteria and viruses are able to cross the placental barrier – meaning they can be passed from a pregnant woman to her fetus. Researchers now believe that the fetal gut is colonized during pregnancy. According to David Kinross: " | Evidence is also growing that certain bacteria and viruses are able to cross the placental barrier – meaning they can be passed from a pregnant woman to her fetus. Researchers now believe that the fetal gut is colonized during pregnancy. According to David Kinross: " | ||
- | The amniotic fluid of women not in labor (with intact membranes) has traditionally been considered to be free of bacteria based on studies using cultivation techniques.(({{pubmed> | + | The amniotic fluid of women not in labor (with intact membranes) has traditionally been considered to be free of bacteria based on studies using cultivation techniques.(({{pmid> |
People whose parents harbor high loads of pathogens are much more likely to fall ill with a chronic disease earlier in life. Research indicates that L-form bacteria are able to survive in sperm, so a father can pass these pathogens to his child at the moment of conception. Evidence is also growing that L-form bacteria and other pathogens are able to cross the placental barrier – meaning they can be passed from a pregnant woman to her fetus. | People whose parents harbor high loads of pathogens are much more likely to fall ill with a chronic disease earlier in life. Research indicates that L-form bacteria are able to survive in sperm, so a father can pass these pathogens to his child at the moment of conception. Evidence is also growing that L-form bacteria and other pathogens are able to cross the placental barrier – meaning they can be passed from a pregnant woman to her fetus. | ||
- | Researchers at Peking University in Beijing recently discovered that the H5N1 bird flu virus can pass through a pregnant woman’s placenta to infect her fetus.(({{pubmed> | + | Researchers at Peking University in Beijing recently discovered that the H5N1 bird flu virus can pass through a pregnant woman’s placenta to infect her fetus.(({{pmid> |
- | Inflammation, | + | Inflammation, |
- | [{{ : | + | [{{ : |
==== To newborns in their first weeks of life ==== | ==== To newborns in their first weeks of life ==== | ||
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A person’s age at the time of infection — from intrauterine [occurring within the uterus] or perinatal (the time period surrounding birth), through childhood and adolescence, | A person’s age at the time of infection — from intrauterine [occurring within the uterus] or perinatal (the time period surrounding birth), through childhood and adolescence, | ||
- | // | + | // |
- | Dave Relman and team at Stanford University found that infants pick up many of the species that make up their gut flora from family members within a few weeks of birth.(({{pubmed> | + | Dave Relman and team at Stanford University found that infants pick up many of the species that make up their gut flora from family members within a few weeks of birth.(({{pmid> |
This is evidence that pathogens are easily transmitted from family to child during the initial periods of life. Both the innate and the adaptive immune systems of infants are particularly susceptible to pathogens, which can drive chronic disease later in life. | This is evidence that pathogens are easily transmitted from family to child during the initial periods of life. Both the innate and the adaptive immune systems of infants are particularly susceptible to pathogens, which can drive chronic disease later in life. | ||
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While the innate immune system, the body's first line of defense against pathogens, is functioning at birth, it takes several weeks for an infant to develop a working adaptive immune system. Recent research has shed light on this formative period of life. | While the innate immune system, the body's first line of defense against pathogens, is functioning at birth, it takes several weeks for an infant to develop a working adaptive immune system. Recent research has shed light on this formative period of life. | ||
- | Nobel Laureate Rolf Zinkernagel injected cytomegalovirus (CMV) into the brains of a group of newborn mice. The adaptive immune system of these mice had not yet developed and consequently they were not producing lymphocytes. The researchers found that the innate immune systems of the mice were able to eliminate CMV from most of the tissues except for those of the central nervous system. As a result, the virus persisted in the brains of the mice. Later in life, when the same mice were challenged by infection with a similar virus, they developed a condition resembling a type of autoimmune disease and died. The team referred to this concept as viral "deja vu." | + | Nobel Laureate Rolf Zinkernagel injected cytomegalovirus (CMV) into the brains of a group of newborn mice. The adaptive immune system of these mice had not yet developed and consequently they were not producing lymphocytes. The researchers found that the innate immune systems of the mice were able to eliminate CMV from most of the tissues except for those of the central nervous system. As a result, the virus persisted in the brains of the mice. Later in life, when the same mice were challenged by infection with a similar virus, they developed a condition resembling a type of autoimmune disease and died. The team referred to this concept as viral "deja vu." |
A second group of mice were not exposed to the CMV virus until they were fully grown and their adaptive immune systems had completely developed. When these mice were exposed to CMV later in life, they were able to successfully fight the virus and lived. | A second group of mice were not exposed to the CMV virus until they were fully grown and their adaptive immune systems had completely developed. When these mice were exposed to CMV later in life, they were able to successfully fight the virus and lived. | ||
- | Similarly, re-exposure of aged individuals to respiratory syncytial virus (RSV) – usually the first pathogen that a human infant encounters – can cause lesions similar to those that occur in infants.(({{pubmed> | + | Similarly, re-exposure of aged individuals to respiratory syncytial virus (RSV) – usually the first pathogen that a human infant encounters – can cause lesions similar to those that occur in infants.(({{pmid> |
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=== Innate immune system === | === Innate immune system === | ||
- | The infant' | + | The infant' |
However, the defense is imperfect. As discussed above, some neonates' | However, the defense is imperfect. As discussed above, some neonates' | ||
- | One five-year study found that newborns who harbor certain types of bacteria in their throats, including // | + | One five-year study found that newborns who harbor certain types of bacteria in their throats, including // |
- | According to Dr. Erika von Mutius, from University Children’s Hospital in Munich, Germany, these findings may be interpreted to suggest that the presence and growth of bacteria in the throat in the first four weeks of life “indicates a defective innate immune response very early in life, which promotes the development of asthma.”(({{pubmed> | + | According to Dr. Erika von Mutius, from University Children’s Hospital in Munich, Germany, these findings may be interpreted to suggest that the presence and growth of bacteria in the throat in the first four weeks of life “indicates a defective innate immune response very early in life, which promotes the development of asthma.”(({{pmid> |
This finding “opens new perspectives for the understanding and prediction of recurrent wheeze and asthma in young children”, | This finding “opens new perspectives for the understanding and prediction of recurrent wheeze and asthma in young children”, | ||
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Spouses have a significantly greater chance of developing the same disease as their partners - a phenomenon that can best be explained if [[home: | Spouses have a significantly greater chance of developing the same disease as their partners - a phenomenon that can best be explained if [[home: | ||
- | * **sarcoidosis among spouses** – One study of sarcoidosis found that among the 215 study participants who had been diagnosed with sarcoidosis, | + | * **sarcoidosis among spouses** – One study of sarcoidosis found that among the 215 study participants who had been diagnosed with sarcoidosis, |
- | * **hypertension among spouses** – British researchers found that men whose spouses had hypertension had a two-fold increased risk of hypertension. Similarly, women whose spouses had hypertension also doubled their risk of developing the disease. The risk for both male and female subjects //persisted after adjustment for other variables such as diet//.(({{pubmed> | + | * **hypertension among spouses** – British researchers found that men whose spouses had hypertension had a two-fold increased risk of hypertension. Similarly, women whose spouses had hypertension also doubled their risk of developing the disease. The risk for both male and female subjects //persisted after adjustment for other variables such as diet//.(({{pmid> |
- | * **dementia among caregivers** – A subject whose spouse experienced incident dementia onset had a [[http:// | + | * **dementia among caregivers** – A subject whose spouse experienced incident dementia onset had a [[https:// |
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==== Social contact ==== | ==== Social contact ==== | ||
- | A number of studies of unrelated people shows that mere proximity seems to be enough to transmit chronic disease. A case-controlled study of residents of the Isle of Man found that 40% of people with sarcoidosis had been in social contact with a person known to have the disease, compared with 1-2% of the control subjects.(({{pubmed> | + | A number of studies of unrelated people shows that mere proximity seems to be enough to transmit chronic disease. A case-controlled study of residents of the Isle of Man found that 40% of people with sarcoidosis had been in social contact with a person known to have the disease, compared with 1-2% of the control subjects.(({{pmid> |
- | Research also suggests that the inflammatory disease obesity is caused by certain species of the Th1 pathogens. | + | Research also suggests that the inflammatory disease obesity is caused by certain species of the Th1 pathogens. |
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=== Pasteurization and refrigeration === | === Pasteurization and refrigeration === | ||
- | According to Cornell researchers, | + | According to Cornell researchers, |
The spores are not only resistant to heat, the small jolt of heat during pasteurization may actually stimulate them to germinate. Some can reproduce in refrigerated dairy products at temperatures that would stymy other types of bacteria. // | The spores are not only resistant to heat, the small jolt of heat during pasteurization may actually stimulate them to germinate. Some can reproduce in refrigerated dairy products at temperatures that would stymy other types of bacteria. // | ||
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=== Microbes in meat === | === Microbes in meat === | ||
- | A study published in //BMC Microbiology// | + | A study published in //BMC Microbiology// |
- | According to a 2011 research study, meat commonly found on grocery store shelves contain high levels of the microbes // | + | According to a 2011 research study, meat commonly found on grocery store shelves contain high levels of the microbes // |
- | "Staph causes hundreds of thousands of infections in the United States every year," the lead researcher, Dr. Lance Price, said in an [[http:// | + | "Staph causes hundreds of thousands of infections in the United States every year," the lead researcher, Dr. Lance Price, said in an [[https:// |
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- | Pinto //et al.// performed 16s rRNA gene based pyrsosequencing on water at a variety of stages in a drinking water distribution system. The team found a consistent diversity of bacteria at every stage of the multi-stage process including 16 phyla in the disinfection tank.((Pinto A, Xi C, Raskin L. (2012), [[http:// | + | Pinto //et al.// performed 16s rRNA gene based pyrsosequencing on water at a variety of stages in a drinking water distribution system. The team found a consistent diversity of bacteria at every stage of the multi-stage process including 16 phyla in the disinfection tank.((Pinto A, Xi C, Raskin L. (2012), [[https:// |
==== Travel ==== | ==== Travel ==== | ||
- | According to a 2012 //BMJ// paper, elite athletes travelling to international destinations >5 time zone differences from their home country have a 2–3-fold increased risk of illness.(({{pubmed> | + | According to a 2012 //BMJ// paper, elite athletes travelling to international destinations >5 time zone differences from their home country have a 2–3-fold increased risk of illness.(({{pmid> |
- | In its [[http:// | + | In its [[https:// |
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- | The literature contains multiple reports of sarcoidosis patients developing skin lesions within tattoos. According to one researcher, this is "a well-recognized occurrence in patients with sarcoidosis." | + | The literature contains multiple reports of sarcoidosis patients developing skin lesions within tattoos. According to one researcher, this is "a well-recognized occurrence in patients with sarcoidosis." |
That a tattoo procedure could routinely induce this kind of reaction strongly suggests that some needles are infected with bacteria. | That a tattoo procedure could routinely induce this kind of reaction strongly suggests that some needles are infected with bacteria. | ||
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[[home: | [[home: | ||
- | Organs and tissue from sarcoidosis patients have been known to cause sarcoidosis in the transplant recipients.(({{pubmed> | + | Organs and tissue from sarcoidosis patients have been known to cause sarcoidosis in the transplant recipients.(({{pmid> |
==== Insect bites and other infectious triggers ==== | ==== Insect bites and other infectious triggers ==== | ||
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[{{ : | [{{ : | ||
- | As with mosquitoes, which transfer malaria in tropical areas, insect bites including ticks can transfer pathogenic bacteria. Chung et al found that a cancer drug, Erbitux, was more likely to cause an allergic-type reaction in regions of the country with higher insect populations.(({{pubmed> | + | As with mosquitoes, which transfer malaria in tropical areas, insect bites including ticks can transfer pathogenic bacteria. Chung et al found that a cancer drug, Erbitux, was more likely to cause an allergic-type reaction in regions of the country with higher insect populations.(({{pmid> |
- | It is widely assumed that chronic Lyme disease is the result of a tick bite and occurs when bacteria such as //Borellia burgdorferi// | + | It is widely assumed that chronic Lyme disease is the result of a tick bite and occurs when bacteria such as //Borellia burgdorferi// |
As discussed above, Zinkernagel and Bisgard have shown that exposure to a pathogen at a formative time in development can later predispose an individual to chronic disease, a phenomenon Zinkernagel calls “bacterial déjà vu.” In the context of chronic Lyme disease and any of the other diseases thought to be caused by insect bites alone, bacterial déjà vu makes sense. An infant is exposed to a certain pathogen early in life when the immune system is not fully functional, and becomes uniquely predisposed him or her to triggers for chronic illness later in life. | As discussed above, Zinkernagel and Bisgard have shown that exposure to a pathogen at a formative time in development can later predispose an individual to chronic disease, a phenomenon Zinkernagel calls “bacterial déjà vu.” In the context of chronic Lyme disease and any of the other diseases thought to be caused by insect bites alone, bacterial déjà vu makes sense. An infant is exposed to a certain pathogen early in life when the immune system is not fully functional, and becomes uniquely predisposed him or her to triggers for chronic illness later in life. | ||
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===== Airborne dispersal ====== | ===== Airborne dispersal ====== | ||
- | In 2011, Wilkinson //et al.// [[http:// | + | In 2011, Wilkinson //et al.// [[https:// |
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- | In 2006, Jeremy Dumas //et al// analyzed the non-human metabolites in urine taken from population samples in Aito Town, Japan; Chicago, IL; and Guangxi, China.(({{pubmed> | + | In 2006, Jeremy Dumas //et al// analyzed the non-human metabolites in urine taken from population samples in Aito Town, Japan; Chicago, IL; and Guangxi, China.(({{pmid> |
Interestingly, | Interestingly, | ||
- | Dumas' | + | Dumas' |
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==== Microbial variability may be relatively unrelated to food intake ==== | ==== Microbial variability may be relatively unrelated to food intake ==== | ||
- | While Dumas has shown that there are significant inter-regional differences in metabolites, | + | While Dumas has shown that there are significant inter-regional differences in metabolites, |
--></ | --></ | ||
===== Disabled immune response increases susceptibility to acute infections ===== | ===== Disabled immune response increases susceptibility to acute infections ===== | ||
- | Certainly the exposure to and acquisition of new bacteria plays a role in the development of disease, but these factors don't account for everything. Diseases appear to strike randomly if for no other reason than their massive incidence and mortality. But, a close look at the evidence suggests that diseases tend to strike those who are most vulnerable. This is true even for acute infections such as the Black Death, the deadliest known epidemic in human history. The results of one analysis of 14th century skeletal remains found that "the Black Death did not kill indiscriminately - that it was, in fact, selective with respect to frailty...." | + | Certainly the exposure to and acquisition of new bacteria plays a role in the development of disease, but these factors don't account for everything. Diseases appear to strike randomly if for no other reason than their massive incidence and mortality. But, a close look at the evidence suggests that diseases tend to strike those who are most vulnerable. This is true even for acute infections such as the Black Death, the deadliest known epidemic in human history. The results of one analysis of 14th century skeletal remains found that "the Black Death did not kill indiscriminately - that it was, in fact, selective with respect to frailty...." |
- | < | + | < |
//**Trevor Marshall, PhD**//</ | //**Trevor Marshall, PhD**//</ | ||
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According to the Marshall Pathogenesis, | According to the Marshall Pathogenesis, | ||
- | Bacterial pathogens themselves can make a human host more hospitable | + | Bacterial pathogens themselves can make a human host more hospitable |
- | Bacteria are allowed to further proliferate when a person consumes any number of [[http:// | + | Bacteria are allowed to further proliferate when a person consumes any number of [[https:// |
===== Read more ===== | ===== Read more ===== | ||
- | * [[http:// | + | * [[https:// |
* | * | ||
- | * [[http:// | + | * [[https:// |
- | * **Colic may be caused by H. pylori** – Colic is a condition in which an otherwise healthy baby cries for more than three hours per day, more than 3 days per week. A 2012 Egyptian study used a stool antigen test to determine if the babies were infected if infants had // | + | * **Colic may be caused by H. pylori** – Colic is a condition in which an otherwise healthy baby cries for more than three hours per day, more than 3 days per week. A 2012 Egyptian study used a stool antigen test to determine if the babies were infected if infants had // |
- | * [[http:// | + | * [[https:// |
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{{tag> Pathogenesis}} | {{tag> Pathogenesis}} | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
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- | < | + | < |
Human Fetal Immune System Arises from Entirely Different Source Than Adult Immune System | Human Fetal Immune System Arises from Entirely Different Source Than Adult Immune System | ||
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- | ===== References ===== | + | ===== References =====</ |