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home:pathogenesis:vitamind:cancer [02.10.2019] – [Evidence that vitamin D intake increases incidence of cancer] sallieqhome:pathogenesis:vitamind:cancer [01.14.2020] – [Vitamin D and cancer] sallieq
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   * **[[home:pathogenesis:vitamind:latitude|Latitude studies]]** - The "latitude studies" are observational, as opposed to interventional, studies, which use ambient solar UV radiation as a proxy for latitude and vitamin D status. For these studies, researchers compare rates of certain major cancers - most notably breast, colorectal and prostate cancer - to rates of sunlight exposure. This group of research has the liability of being wildly inconsistent. The choice to publish research on a specific latitude gradient may be a better proxy for a researcher's bias.   * **[[home:pathogenesis:vitamind:latitude|Latitude studies]]** - The "latitude studies" are observational, as opposed to interventional, studies, which use ambient solar UV radiation as a proxy for latitude and vitamin D status. For these studies, researchers compare rates of certain major cancers - most notably breast, colorectal and prostate cancer - to rates of sunlight exposure. This group of research has the liability of being wildly inconsistent. The choice to publish research on a specific latitude gradient may be a better proxy for a researcher's bias.
   * **Interventional studies** - While some randomized controlled trials have suggested that consuming vitamin D reduces rates of cancer, larger and more carefully controlled studies show no such effect.    * **Interventional studies** - While some randomized controlled trials have suggested that consuming vitamin D reduces rates of cancer, larger and more carefully controlled studies show no such effect. 
-  * **Studies of vitamin D status** - Many of the studies examining the relationship between vitamin D status and incidence of cancer argue that low levels of 25-D contribute to cancer. This conclusion has been invalidated by larger well-controlled studies. Although the immune system works to downregulate 25-D (25-hydroxyvitamin D) in inflammatory diseases such as cancer, very high levels of 25-D are a clear indication of regular supplementation. These studies suggest that consuming large amounts of vitamin D predispose a person to increased incidence of cancer.+  * **Studies of vitamin D status** - Many of the studies examining the relationship between vitamin D status and incidence of cancer argue that low levels of 25-D contribute to cancer. This conclusion has been invalidated by larger well-controlled studies. Although the immune system works to downregulate 25-D (25-hydroxyvitamin D) in inflammatory diseases such as cancer, very high levels of 25-D are a clear indication of regular supplementation. Studies suggest that consuming large amounts of vitamin D predispose a person to increased incidence of cancer.
   * **Observational studies** – Some case control studies have found that vitamin D intake seems to increase incidence of certain types of cancer.   * **Observational studies** – Some case control studies have found that vitamin D intake seems to increase incidence of certain types of cancer.
  
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 Researchers at the Chinese Academy of Medical Sciences in China found a similar association between excessive vitamin D intake and esophageal and gastric cancers in men. Male subjects with levels of 25-D in the range of 48.7 ng/ml (which once again suggests heavy supplementation) were much more likely to develop one of the two forms of cancer.(({{pubmed>long:17551495}})) A 2011 case control study found that those in the highest 25% of vitamin D intake compared to those in the lowest 25% were significantly more likely to develop oesophageal adenocarcinoma.(({{pubmed>long:21736847}})) Researchers at the Chinese Academy of Medical Sciences in China found a similar association between excessive vitamin D intake and esophageal and gastric cancers in men. Male subjects with levels of 25-D in the range of 48.7 ng/ml (which once again suggests heavy supplementation) were much more likely to develop one of the two forms of cancer.(({{pubmed>long:17551495}})) A 2011 case control study found that those in the highest 25% of vitamin D intake compared to those in the lowest 25% were significantly more likely to develop oesophageal adenocarcinoma.(({{pubmed>long:21736847}}))
  
-The following research by  remains unpublished+The following research by //Freedman DM, Looker AC, Abnet CC, Linet MS, Graubard BI// remains unpublished
 <blockquote>Abstract Vitamin D has been hypothesized to protect against cancer. We followed 16,819 participants in NHANES III from 1988 through 2006, expanding upon an earlier NHANES III study (1988-2000). Using Cox proportional hazard regression models, we examined risk related to baseline serum 25-hydroxyvitamin D (25(OH)D) for total cancer mortality, in both sexes, and by racial/ethnic groups, as well as for site-specific cancers. Because serum was collected in the south in cooler months and the north in warmer months, we examined associations by collection season (“summer/higher latitude” and “winter/lower latitude”). We identified 884 cancer deaths during 225,212 person-years. Overall cancer mortality risks were unrelated to baseline 25(OH)D status in both season/latitude groups, and in non-Hispanic whites, non-Hispanic blacks, and Mexican-Americans. In men, risks were elevated at higher levels (e.g., for ≥100 nmol/L, RR= 1.85 (95% CI=1.02-3.35) compared to <37.5 nmol/L).</blockquote> <blockquote>Abstract Vitamin D has been hypothesized to protect against cancer. We followed 16,819 participants in NHANES III from 1988 through 2006, expanding upon an earlier NHANES III study (1988-2000). Using Cox proportional hazard regression models, we examined risk related to baseline serum 25-hydroxyvitamin D (25(OH)D) for total cancer mortality, in both sexes, and by racial/ethnic groups, as well as for site-specific cancers. Because serum was collected in the south in cooler months and the north in warmer months, we examined associations by collection season (“summer/higher latitude” and “winter/lower latitude”). We identified 884 cancer deaths during 225,212 person-years. Overall cancer mortality risks were unrelated to baseline 25(OH)D status in both season/latitude groups, and in non-Hispanic whites, non-Hispanic blacks, and Mexican-Americans. In men, risks were elevated at higher levels (e.g., for ≥100 nmol/L, RR= 1.85 (95% CI=1.02-3.35) compared to <37.5 nmol/L).</blockquote>
  
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-  * [[http://www.landesbioscience.com/journals/dermatoendocrinology/Grant(3)DE2-2.pdf|Obituary of epidemiologist Dr. Frank Garland]] – Garland used ecological (population-based) studies to conclude that vitamin D "deficiency" increased risk for cancer. One of the most outspoken proponents of supplementation with vitamin D, Garland died in 2010 at the age of 60… from cancer. +  * [[https://en.wikipedia.org/wiki/Frank_C._Garland|Dr Frank C Garland]] used ecological (population-based) studies to conclude that vitamin D "deficiency" increased risk for cancer. One of the most outspoken proponents of supplementation with vitamin D, Garland died in 2010 at the age of 60… from cancer. 
  
  
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 {{tag>pathogenesis Science_behind_vitamin_D}} {{tag>pathogenesis Science_behind_vitamin_D}}
 ===== Notes and comments ===== ===== Notes and comments =====
 +
 +broken link  [[http://www.landesbioscience.com/journals/dermatoendocrinology/Grant(3)DE2-2.pdf|Obituary of epidemiologist Dr. Frank Garland]] 
  
  
home/pathogenesis/vitamind/cancer.txt · Last modified: 09.14.2022 by 127.0.0.1
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