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home:pathogenesis:vitamind:mechanisms [01.25.2019]
sallieq [Recent research]
home:pathogenesis:vitamind:mechanisms [01.25.2019] (current)
sallieq [Recent research]
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 We evaluated whether the ability of M. leprae to induce type I IFN blocks the intrinsic activation of the vitamin D pathway, representing an escape mechanism by which the bacterium evades the host response. ​   (({{pubmed>​long:​30300363}})) ​ We evaluated whether the ability of M. leprae to induce type I IFN blocks the intrinsic activation of the vitamin D pathway, representing an escape mechanism by which the bacterium evades the host response. ​   (({{pubmed>​long:​30300363}})) ​
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 +<​blockquote>​Vitamin D plays a crucial role in the regulation of genes central to protection against microbe invasion, such as the induction of the expression of antimicrobial peptides (also known as host defense peptides) such as CAMP and defensin. These peptides were demonstrated to disrupt the integrity of the microbe membrane, resulting in its death (Gombart, 2009). In addition, Vitamin D regulates the immune system by managing the expression of TNFα (Golovko et al., 2005), one of the most important pro-inflammatory and pro-immune cytokines. Therefore, downregulation of the vitamin D signaling pathway by viruses, can result in decreased production of antimicrobial peptides and cytokines and as a result, to attenuation of the immune response. Several studies have previously indicated that certain viruses can inhibit the Vitamin D signal transduction.
 +</​blockquote>​ Our in-vitro study showed that Vitamin D does not affect the rate of HBV replication,​ and downregulates VDR levels in the presence of the virus, thereby attenuating vitamin D signal transduction. ​  ​(({{pubmed>​long:​30326825}})) ​
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home/pathogenesis/vitamind/mechanisms.txt · Last modified: 01.25.2019 by sallieq
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