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home:pathogenesis:vitamind:metabolism [06.21.2017] – [At the site of infection] sallieq | home:pathogenesis:vitamind:metabolism [01.01.2019] – [Notes and comments] sallieq | ||
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Located in the nucleus of a variety of cells including immune cells, the VDR is a control system of sorts. When exposed to infection and damage, especially that which is caused by pathogens, the body begins to convert the inactive form 25-D into the active form, 1,25-D. As cellular concentrations of 1,25-D increase, 1,25-D activates the VDR, turning on any number of genes the receptor transcribes. | Located in the nucleus of a variety of cells including immune cells, the VDR is a control system of sorts. When exposed to infection and damage, especially that which is caused by pathogens, the body begins to convert the inactive form 25-D into the active form, 1,25-D. As cellular concentrations of 1,25-D increase, 1,25-D activates the VDR, turning on any number of genes the receptor transcribes. | ||
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According to a 2010 analysis, the VDR significantly affects 229 human genes. Many of these genes have long been associated with autoimmune diseases and cancers including, for example, the genes IRF8 (linked to multiple sclerosis), and PTPN2 (connected to Crohn' | According to a 2010 analysis, the VDR significantly affects 229 human genes. Many of these genes have long been associated with autoimmune diseases and cancers including, for example, the genes IRF8 (linked to multiple sclerosis), and PTPN2 (connected to Crohn' | ||
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+ | ===== Read more research ===== | ||
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===== Notes and comments ===== | ===== Notes and comments ===== | ||
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- | Not sure where this should go. Here? Psoriasis? Innate immunity? | + | Not sure where this should go. Here? Psoriasis? Innate immunity? |
PLoS One. 2009 Jul 22; | PLoS One. 2009 Jul 22; |
home/pathogenesis/vitamind/metabolism.txt · Last modified: 09.14.2022 by 127.0.0.1
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