This shows you the differences between two versions of the page.
Both sides previous revisionPrevious revisionNext revision | Previous revision | ||
home:pathogenesis:vitamind:pregnancy [07.02.2009] – paulalbert | home:pathogenesis:vitamind:pregnancy [09.14.2022] (current) – external edit 127.0.0.1 | ||
---|---|---|---|
Line 1: | Line 1: | ||
+ | ====== Pregnancy and vitamin D ====== | ||
+ | |||
+ | < | ||
+ | |||
+ | |||
+ | 1,25-D rises by 40% in the early pregnant decidua, meaning that its ability to dysregulate the nuclear | ||
+ | receptors and the antimicrobial peptides (AmPs) they express is particularly prevalent during the first trimesters of pregnancy. | ||
+ | |||
+ | |||
+ | ===== Pregnancy increases 1,25-D ===== | ||
+ | |||
+ | The following are some of the characteristics of 1,25-D related to pregnancy: | ||
+ | |||
+ | * The 1,25-D levels increase throughout pregnancy in healthy women.(({{pmid> | ||
+ | * The level of 1,25-D is highest in the third trimester and falls soon after delivery in healthy women.(({{pmid> | ||
+ | * Increased serum 1,25-D levels persist through lactation.(({{pmid> | ||
+ | * High levels of 1,25-D during pregnancy can cause increased somnolence, fatigue and symptoms such as joint pain and breathing problems. | ||
+ | * A healthy woman will have 1,25-D manufactured by the placenta during pregnancy, but the manufacture of 1,25-D in the kidneys will be down-regulated to compensate. The kidneys of a person with advanced Th1 disease, however, have usually lost the ability to adequately down-regulate the 1,25-D level, as there is too much 1,25-D being manufactured in the inflammation, | ||
+ | * The interpretation of the 1,25-D data value during pregnancy will be more difficult. The 25-D levels may also be an aid to interpretation. | ||
+ | |||
+ | ===== Pregnancy may cause disease exacerbation ===== | ||
+ | |||
+ | In pregnancy, the placenta manufactures 1, | ||
+ | |||
+ | < | ||
+ | |||
+ | So females will have exposure to high levels of 1,25-D, sufficient to allow CWD to proliferate during pregnancy. | ||
+ | |||
+ | That is why there is a high rate of diagnosis of Th1 disease post-partum, | ||
+ | |||
+ | //**Trevor Marshall, PhD**// </ | ||
+ | |||
+ | |||
+ | |||
+ | ===== Related publications and presentations ===== | ||
+ | |||
+ | {{topic> | ||
+ | |||
+ | [[https:// | ||
+ | |||
+ | {{tag> | ||
+ | |||
+ | |||
+ | |||
+ | |||
+ | < | ||
+ | ===== Notes and comments ===== | ||
+ | |||
+ | * pregnancy may cause feelings of perceived wellness | ||
+ | * Legacy content | ||
+ | * e75 | ||
+ | |||
+ | |||
+ | ===== References ===== | ||
+ | </ | ||