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home:patients:glossary [09.08.2010] – paulalbert | home:patients:glossary [08.23.2014] – paulalbert | ||
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Terms with an asterisk (e.g. < | Terms with an asterisk (e.g. < | ||
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* **autoimmune** – A condition or disease thought to arise from an overactive immune response of the body against substances and tissues normally present in the body. | * **autoimmune** – A condition or disease thought to arise from an overactive immune response of the body against substances and tissues normally present in the body. | ||
* **Autoimmunity Research Foundation** – Non-profit foundation dedicated to exploring a pathogenesis and therapy for chronic disease. | * **Autoimmunity Research Foundation** – Non-profit foundation dedicated to exploring a pathogenesis and therapy for chronic disease. | ||
- | * **azithromycin (Zithromax)** – Bacteriostatic antibiotic used by Marshall Protocol patients. Has relatively long half-life. | ||
- | * **Bactrim DS** – Sulfa antibiotic used by patients on the Marshall Protocol. Combination of sulfamethoxazole and trimethoprim. Works by locking bacterial folic acid synthesis. | ||
* **beta-Defensin** – An antimicrobial peptide found primarily in immune cells and transcribed by the Vitamin D Receptor. | * **beta-Defensin** – An antimicrobial peptide found primarily in immune cells and transcribed by the Vitamin D Receptor. | ||
* **biofilm** – A structured community of microorganisms encapsulated within a self-developed protective matrix and living together. | * **biofilm** – A structured community of microorganisms encapsulated within a self-developed protective matrix and living together. | ||
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* **chlorogenic acid** – An antioxidant and phenolic compound, which in ways that are not yet fully clear, can modulate and/or suppress the immune response. | * **chlorogenic acid** – An antioxidant and phenolic compound, which in ways that are not yet fully clear, can modulate and/or suppress the immune response. | ||
* **chronic bacteria/ | * **chronic bacteria/ | ||
- | * **clindamycin** – Bacteriostatic antibiotic used by patients on the Marshall Protocol. | ||
* **cognitive dysfunction** – The loss of intellectual functions, such as reasoning, memory loss, and other neurological abilities, that is severe enough to interfere with daily functioning. | * **cognitive dysfunction** – The loss of intellectual functions, such as reasoning, memory loss, and other neurological abilities, that is severe enough to interfere with daily functioning. | ||
* **corticosteroids** – A first-line treatment for a number of diseases. Corticosteroids work by slowing the innate immune response. This provides some patients with temporary symptom palliation, but exacerbates the disease over the long-term by allowing chronic pathogens to proliferate. | * **corticosteroids** – A first-line treatment for a number of diseases. Corticosteroids work by slowing the innate immune response. This provides some patients with temporary symptom palliation, but exacerbates the disease over the long-term by allowing chronic pathogens to proliferate. | ||
* **cytokines** – Any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system. | * **cytokines** – Any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system. | ||
- | * **demeclocycline** – Bacteriostatic antibiotic used by patients on the Marshall Protocol. | ||
* **endotoxin** – A toxin associated with the outer membranes of bacteria, especially gram-negative bacteria. When these bacteria are destroyed, as will happen during the MP, endotoxins are released, causing a spike in symptoms known as the immunopathological reaction. | * **endotoxin** – A toxin associated with the outer membranes of bacteria, especially gram-negative bacteria. When these bacteria are destroyed, as will happen during the MP, endotoxins are released, causing a spike in symptoms known as the immunopathological reaction. | ||
* **familial aggregation** – Occurrence of a given trait shared by members of a family (or community) that cannot be readily accounted for by chance. | * **familial aggregation** – Occurrence of a given trait shared by members of a family (or community) that cannot be readily accounted for by chance. | ||
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* **metagenomic microbiota** – The community of bacterial pathogens, including those in an intracellular and biofilm state which cause chronic disease. | * **metagenomic microbiota** – The community of bacterial pathogens, including those in an intracellular and biofilm state which cause chronic disease. | ||
* **microbiota** – The bacterial community which causes chronic diseases; one which almost certainly includes multiple species and bacterial forms. | * **microbiota** – The bacterial community which causes chronic diseases; one which almost certainly includes multiple species and bacterial forms. | ||
- | | + | * **minocycline** – Bacteriostatic antibiotic |
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* **murine model** – A model of disease which uses rats or mice to mimic human conditions. | * **murine model** – A model of disease which uses rats or mice to mimic human conditions. | ||
* **neurological immunopathology** – A temporary exacerbation of neurological symptoms due to bacterial death. | * **neurological immunopathology** – A temporary exacerbation of neurological symptoms due to bacterial death. | ||
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* **photosensitivity** – Abnormal sensitivity to sunlight and bright lights. Also referred to as "sun flare" or "light flare." | * **photosensitivity** – Abnormal sensitivity to sunlight and bright lights. Also referred to as "sun flare" or "light flare." | ||
* **previtamin D3** – Largely inactive vitamin D metabolite, naturally occurring in the human body. When exposed to ultraviolet radiation converted into 25-D. Also known as 7-dehydrocholesterol. | * **previtamin D3** – Largely inactive vitamin D metabolite, naturally occurring in the human body. When exposed to ultraviolet radiation converted into 25-D. Also known as 7-dehydrocholesterol. | ||
- | * **pulsed low dosing** – Administration of an antibiotic periodically, | ||
* **Pregnane Xenobiotic Receptor (PXR)** – Nuclear receptor which inhibits conversion of pre-vitamin D to 25-D, causing 25-D levels to drop via the CYP27A1 pathway. More significantly though, it transcribes CYP3A4, an enzyme which breaks down 1,25-D. | * **Pregnane Xenobiotic Receptor (PXR)** – Nuclear receptor which inhibits conversion of pre-vitamin D to 25-D, causing 25-D levels to drop via the CYP27A1 pathway. More significantly though, it transcribes CYP3A4, an enzyme which breaks down 1,25-D. | ||
* **quercetin** – Antioxidant supplement taken by some Marshall Protocol patients to limit intolerable immunopathology. Quercetin inhibits production of Nuclear Factor-kappa B, an inflammatory cytokine. | * **quercetin** – Antioxidant supplement taken by some Marshall Protocol patients to limit intolerable immunopathology. Quercetin inhibits production of Nuclear Factor-kappa B, an inflammatory cytokine. | ||
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* **Th1 Pathogens* ** – The community of bacterial pathogens which cause chronic inflammatory disease; one which almost certainly includes multiple species and bacterial forms. | * **Th1 Pathogens* ** – The community of bacterial pathogens which cause chronic inflammatory disease; one which almost certainly includes multiple species and bacterial forms. | ||
* **Th1 Spectrum Disorder* ** – The overlap of different disease symptoms in different patients with similar diagnoses--caused by the fact that any one bacterial species can contribute to numerous disease states. | * **Th1 Spectrum Disorder* ** – The overlap of different disease symptoms in different patients with similar diagnoses--caused by the fact that any one bacterial species can contribute to numerous disease states. | ||
- | * **tetracycline antibiotics** – Family of bacteriostatic antibiotics, | ||
* **therapeutic probe* ** – A brief trial of the Marshall Protocol to see if it will generate an immunopathological response. The "gold standard" | * **therapeutic probe* ** – A brief trial of the Marshall Protocol to see if it will generate an immunopathological response. The "gold standard" | ||
* **TLR2** – A receptor which is expressed on the surface of certain cells and recognizes native or foreign substances and passes on appropriate signals to the cell and/or the nervous system. Part of the body's innate immune response. | * **TLR2** – A receptor which is expressed on the surface of certain cells and recognizes native or foreign substances and passes on appropriate signals to the cell and/or the nervous system. Part of the body's innate immune response. |