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home:patients:glossary [01.09.2014] – joyfulhome:patients:glossary [10.13.2018] (current) – [Glossary] sallieq
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   * **autoimmune** – A condition or disease thought to arise from an overactive immune response of the body against substances and tissues normally present in the body.   * **autoimmune** – A condition or disease thought to arise from an overactive immune response of the body against substances and tissues normally present in the body.
   * **Autoimmunity Research Foundation** – Non-profit foundation dedicated to exploring a pathogenesis and therapy for chronic disease.   * **Autoimmunity Research Foundation** – Non-profit foundation dedicated to exploring a pathogenesis and therapy for chronic disease.
-  * **azithromycin (Zithromax)** – Bacteriostatic antibiotic **no longer** used by Marshall Protocol patients. Has relatively long half-life. 
-  * **Bactrim DS** – Sulfa antibiotic used by patients on the Marshall Protocol. Combination of sulfamethoxazole and trimethoprim. Works by locking bacterial folic acid synthesis. 
   * **beta-Defensin** – An antimicrobial peptide found primarily in immune cells and transcribed by the Vitamin D Receptor.   * **beta-Defensin** – An antimicrobial peptide found primarily in immune cells and transcribed by the Vitamin D Receptor.
   * **biofilm** – A structured community of microorganisms encapsulated within a self-developed protective matrix and living together.   * **biofilm** – A structured community of microorganisms encapsulated within a self-developed protective matrix and living together.
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   * **chlorogenic acid** – An antioxidant and phenolic compound, which in ways that are not yet fully clear, can modulate and/or suppress the immune response.   * **chlorogenic acid** – An antioxidant and phenolic compound, which in ways that are not yet fully clear, can modulate and/or suppress the immune response.
   * **chronic bacteria/infection/disease** –  In the context of the Marshall Pathogenesis, the term chronic is often used to refer to bacterial infections which persist over a long period of time, often decades. Chronic bacteria are harder to detect and, according to the Marshall Pathogenesis, play a central role in driving chronic inflammatory disease. Examples of chronic diseases include kidney disease, cancer, diabetes, and any of the other dozens of diseases which the MP addresses. //See acute infection.//   * **chronic bacteria/infection/disease** –  In the context of the Marshall Pathogenesis, the term chronic is often used to refer to bacterial infections which persist over a long period of time, often decades. Chronic bacteria are harder to detect and, according to the Marshall Pathogenesis, play a central role in driving chronic inflammatory disease. Examples of chronic diseases include kidney disease, cancer, diabetes, and any of the other dozens of diseases which the MP addresses. //See acute infection.//
-  * **clindamycin** – Bacteriostatic antibiotic used by patients on the Marshall Protocol.  
   * **cognitive dysfunction** – The loss of intellectual functions, such as reasoning, memory loss, and other neurological abilities, that is severe enough to interfere with daily functioning.   * **cognitive dysfunction** – The loss of intellectual functions, such as reasoning, memory loss, and other neurological abilities, that is severe enough to interfere with daily functioning.
   * **corticosteroids** – A first-line treatment for a number of diseases. Corticosteroids work by slowing the innate immune response. This provides some patients with temporary symptom palliation, but exacerbates the disease over the long-term by allowing chronic pathogens to proliferate.   * **corticosteroids** – A first-line treatment for a number of diseases. Corticosteroids work by slowing the innate immune response. This provides some patients with temporary symptom palliation, but exacerbates the disease over the long-term by allowing chronic pathogens to proliferate.
   * **cytokines** – Any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system.   * **cytokines** – Any of various protein molecules secreted by cells of the immune system that serve to regulate the immune system.
-  * **demeclocycline** – Bacteriostatic antibiotic used by patients on the Marshall Protocol. 
   * **endotoxin** – A toxin associated with the outer membranes of bacteria, especially gram-negative bacteria. When these bacteria are destroyed, as will happen during the MP, endotoxins are released, causing a spike in symptoms known as the immunopathological reaction.   * **endotoxin** – A toxin associated with the outer membranes of bacteria, especially gram-negative bacteria. When these bacteria are destroyed, as will happen during the MP, endotoxins are released, causing a spike in symptoms known as the immunopathological reaction.
   * **familial aggregation** – Occurrence of a given trait shared by members of a family (or community) that cannot be readily accounted for by chance.   * **familial aggregation** – Occurrence of a given trait shared by members of a family (or community) that cannot be readily accounted for by chance.
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   * **metagenomic microbiota** – The community of bacterial pathogens, including those in an intracellular and biofilm state which cause chronic disease.   * **metagenomic microbiota** – The community of bacterial pathogens, including those in an intracellular and biofilm state which cause chronic disease.
   * **microbiota** – The bacterial community which causes chronic diseases; one which almost certainly includes multiple species and bacterial forms.   * **microbiota** – The bacterial community which causes chronic diseases; one which almost certainly includes multiple species and bacterial forms.
-  * **minimum inhibitory concentration (MIC)** – The lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation. Dosing at well below the MIC improves the MP's effectiveness against slow-growing chronic pathogens and reduces the likelihood of resistance. +  * **minocycline** – Bacteriostatic antibiotic occasionally prescribed for some Marshall Protocol patients as a palliative.
-  * **minocycline** – Bacteriostatic antibiotic used by Marshall Protocol patients.+
   * **murine model** – A model of disease which uses rats or mice to mimic human conditions.   * **murine model** – A model of disease which uses rats or mice to mimic human conditions.
   * **neurological immunopathology** – A temporary exacerbation of neurological symptoms due to bacterial death.   * **neurological immunopathology** – A temporary exacerbation of neurological symptoms due to bacterial death.
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   * **photosensitivity** – Abnormal sensitivity to sunlight and bright lights. Also referred to as "sun flare" or "light flare."   * **photosensitivity** – Abnormal sensitivity to sunlight and bright lights. Also referred to as "sun flare" or "light flare."
   * **previtamin D3** – Largely inactive vitamin D metabolite, naturally occurring in the human body. When exposed to ultraviolet radiation converted into 25-D. Also known as 7-dehydrocholesterol.   * **previtamin D3** – Largely inactive vitamin D metabolite, naturally occurring in the human body. When exposed to ultraviolet radiation converted into 25-D. Also known as 7-dehydrocholesterol.
-  * **pulsed low dosing** – Administration of an antibiotic periodically, such as every 48 hours and in amounts small enough that the immunosuppressive effects of the antibiotics are minimized. 
   * **Pregnane Xenobiotic Receptor (PXR)** – Nuclear receptor which inhibits conversion of pre-vitamin D to 25-D, causing 25-D levels to drop via the CYP27A1 pathway. More significantly though, it transcribes CYP3A4, an enzyme which breaks down 1,25-D.   * **Pregnane Xenobiotic Receptor (PXR)** – Nuclear receptor which inhibits conversion of pre-vitamin D to 25-D, causing 25-D levels to drop via the CYP27A1 pathway. More significantly though, it transcribes CYP3A4, an enzyme which breaks down 1,25-D.
   * **quercetin** – Antioxidant supplement taken by some Marshall Protocol patients to limit intolerable immunopathology. Quercetin inhibits production of Nuclear Factor-kappa B, an inflammatory cytokine.   * **quercetin** – Antioxidant supplement taken by some Marshall Protocol patients to limit intolerable immunopathology. Quercetin inhibits production of Nuclear Factor-kappa B, an inflammatory cytokine.
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   * **Th1 Pathogens* ** – The community of bacterial pathogens which cause chronic inflammatory disease; one which almost certainly includes multiple species and bacterial forms.   * **Th1 Pathogens* ** – The community of bacterial pathogens which cause chronic inflammatory disease; one which almost certainly includes multiple species and bacterial forms.
   * **Th1 Spectrum Disorder* ** – The overlap of different disease symptoms in different patients with similar diagnoses--caused by the fact that any one bacterial species can contribute to numerous disease states.   * **Th1 Spectrum Disorder* ** – The overlap of different disease symptoms in different patients with similar diagnoses--caused by the fact that any one bacterial species can contribute to numerous disease states.
-  * **tetracycline antibiotics** – Family of bacteriostatic antibiotics, a few of which are used by the Marshall Protocol, including clindamycin, demeclocycline, and minocycline. So-called bacterial resistance to the tetracyclines is overcome with the concurrent use of a Vitamin D Receptor agonist, olmesartan (Benicar) and [[home:protocol:mp_antibiotics:dosing|pulsing the antibiotics at low doses]]. 
   * **therapeutic probe* ** – A brief trial of the Marshall Protocol to see if it will generate an immunopathological response. The "gold standard" for testing whether a patient is a good candidate for the MP.   * **therapeutic probe* ** – A brief trial of the Marshall Protocol to see if it will generate an immunopathological response. The "gold standard" for testing whether a patient is a good candidate for the MP.
   * **TLR2** – A receptor which is expressed on the surface of certain cells and recognizes native or foreign substances and passes on appropriate signals to the cell and/or the nervous system. Part of the body's innate immune response.   * **TLR2** – A receptor which is expressed on the surface of certain cells and recognizes native or foreign substances and passes on appropriate signals to the cell and/or the nervous system. Part of the body's innate immune response.
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   * **vitamin D2** – Form of vitamin D created by plants and fungi. When ingested, the secosteroid is (sometimes) converted into 25-D. Also known as ergocholecalciferol.   * **vitamin D2** – Form of vitamin D created by plants and fungi. When ingested, the secosteroid is (sometimes) converted into 25-D. Also known as ergocholecalciferol.
   * **vitamin D3** – Form of vitamin D made in the skin when exposed to light. Also available in fish and meat. This secosteroid is sometimes converted into 25-D. Also known as cholecalciferol and activated 7-dehydrocholesterol.   * **vitamin D3** – Form of vitamin D made in the skin when exposed to light. Also available in fish and meat. This secosteroid is sometimes converted into 25-D. Also known as cholecalciferol and activated 7-dehydrocholesterol.
-  * **VDR agonist** - A substance such as olmesartan (Benicar) or 1,25-D which activates the Vitamin D Receptor and transcribes the genes necessary for a proper innate immune response.+  * **VDR agonist** - A substance such as olmesartan (Benicar) or 1,25-D which activates the Vitamin D Receptor enabling transcription of the genes necessary for a proper innate immune response.
   * **VDR antagonist** - A substance such as 25-D or certain bacterial ligands which inactivates the Vitamin D Receptor, the receptor which transcribes the genes necessary for a proper innate immune response.   * **VDR antagonist** - A substance such as 25-D or certain bacterial ligands which inactivates the Vitamin D Receptor, the receptor which transcribes the genes necessary for a proper innate immune response.
  
  
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home/patients/glossary.txt · Last modified: 10.13.2018 by sallieq
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