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home:patients:grappling_uncertainty [06.06.2019] – [Confronting uncertainty about the Marshall Protocol] sallieq | home:patients:grappling_uncertainty [08.01.2019] – [Understanding studies] sallieq | ||
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===== One pathology, one treatment ===== | ===== One pathology, one treatment ===== | ||
- | People also seem to have trouble grappling with root causes. They may point to a sign or symptom of disease: low blood pressure, elevated cholesterol, | + | People also seem to have trouble grappling with root causes. They may point to a sign or symptom of disease: low blood pressure, elevated cholesterol, anemia, trouble sleeping, low levels of a hormone, etc., and conclude that a certain factor causes the disease. The problem with this line of thinking is that the disease does not go away when that factor is remedied--when medications are used to increase cholesterol or medications are used to decrease blood pressure. On the other hand, patients who take regular frequent doses of olmesartan (Benicar) and in some cases, pulsed low doses of antibiotics do see improvement in their underlying disease. |
===== Evaluating the Marshall Protocol ===== | ===== Evaluating the Marshall Protocol ===== | ||
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For a person who still has doubts about the MP science, perhaps an empirical or observational approach is warranted. Patients should look at what the MP predicts and ask themselves if their reactions are consistent with what has been experienced by every other patient who has succeeded on the MP: | For a person who still has doubts about the MP science, perhaps an empirical or observational approach is warranted. Patients should look at what the MP predicts and ask themselves if their reactions are consistent with what has been experienced by every other patient who has succeeded on the MP: | ||
* "Do I get an increase in the symptoms of my disease, known as immunopathology, | * "Do I get an increase in the symptoms of my disease, known as immunopathology, | ||
- | * "Do I feel calculated increases in the severity of my symptoms following each dose of antibiotics?" | ||
* "Do I feel the temporary immunosuppression caused by antibiotics?" | * "Do I feel the temporary immunosuppression caused by antibiotics?" | ||
* "While the olmesartan blockade is in place, am I photosensitive?" | * "While the olmesartan blockade is in place, am I photosensitive?" | ||
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Another common source of questions is recent studies. PubMed has tens of millions of studies. Some of them, many in fact, seem to contradict the conclusions put forth in the Knowledge Base or in the ARF research team's published papers. Often, a critical thinker may be able to apply the evidence and criticisms in the Knowledge Base to a study and make sense of it. | Another common source of questions is recent studies. PubMed has tens of millions of studies. Some of them, many in fact, seem to contradict the conclusions put forth in the Knowledge Base or in the ARF research team's published papers. Often, a critical thinker may be able to apply the evidence and criticisms in the Knowledge Base to a study and make sense of it. | ||
- | An example: one study concluded that vitamin D might lower the incidence of colorectal cancer.(({{pubmed> | + | An example: one study concluded that vitamin D might lower the incidence of colorectal cancer.(({{pubmed> |
Using statistical inferences, John P. A. Ioannidis concluded in the prestigious journal //PLoS Medicine// that half of published research must be wrong.(({{pubmed> | Using statistical inferences, John P. A. Ioannidis concluded in the prestigious journal //PLoS Medicine// that half of published research must be wrong.(({{pubmed> | ||
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As before, it is again impossible to predict how long any bout of IP will last, how it will manifest, whether it will become intolerable. | As before, it is again impossible to predict how long any bout of IP will last, how it will manifest, whether it will become intolerable. | ||
- | Sometimes a person decides the MP "does not work" for them | + | Sometimes a person decides the MP "does not work" for them |
- | Our job as support team includes asking MPeers to 'phone home' with information and experiences which will help others, often ways of ameliorating nasty IP whether physical or pharmaceutical. | + | Our job as support team includes asking MPeers to 'phone home' with information and experiences which will help others, often ways of ameliorating nasty IP whether physical or pharmaceutical. |