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home:physicians:vitamin_d_leaflet [06.11.2018] – [A vitamin or a steroid hormone?] sallieq | home:physicians:vitamin_d_leaflet [06.11.2018] – [The Innate Immune response] sallieq | ||
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interpreting the test results. | interpreting the test results. | ||
- | //**The therapeutic target range**// for 25-D is 12ng/ml below which the immune system is fully functional. A 25-D above 25ng/ml will not be able to kill pathogenic bacteria. For 1,25-D the target is <20 pg/ml and is a measure of inflammation. | + | //**The therapeutic target range**// for 25-D is 12ng/ml below which the immune system is fully functional. A 25-D above 25ng/ml will not be able to kill pathogenic bacteria. For 1,25-D the target is <20 pg/ml and is a measure of inflammation. |
Mucosal response and calcium/ | Mucosal response and calcium/ | ||
competence. Thus, calcium and phosphorus absorption may be inhibited if VDR function is impaired by elevated 1,25(OH)2D. Measuring calcium is primarily affected by | competence. Thus, calcium and phosphorus absorption may be inhibited if VDR function is impaired by elevated 1,25(OH)2D. Measuring calcium is primarily affected by | ||
- | PTH status, not VDR competence. | + | PTH status, not VDR competence. |
==== Special Handling of the 1,25D Blood sample ==== | ==== Special Handling of the 1,25D Blood sample ==== | ||
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..is the body's first line of defense against, and non-specific way for responding to bacterial pathogens. Located in the nucleus of a variety of cells, the Vitamin D nuclear receptor (VDR) plays a crucial, often under-appreciated, | ..is the body's first line of defense against, and non-specific way for responding to bacterial pathogens. Located in the nucleus of a variety of cells, the Vitamin D nuclear receptor (VDR) plays a crucial, often under-appreciated, | ||
- | When functioning properly, the VDR transcribes between hundreds and thousands of genes including those for the proteins known as the antimicrobial peptides. | + | When functioning properly, the VDR transcribes between hundreds and thousands of genes including those for the proteins known as the antimicrobial peptides. |
- | Antimicrobial peptides are the body's natural antibiotics, | + | Antimicrobial peptides are the body's natural antibiotics, |
==== The body controls activity of the VDR through regulation of the Vitamin D Metabolites ==== | ==== The body controls activity of the VDR through regulation of the Vitamin D Metabolites ==== |