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--- home:physicians:vitamin_d_leaflet [06.11.2018] – [A vitamin or a steroid hormone?] sallieq
+++ home:physicians:vitamin_d_leaflet [06.11.2018] – [The body controls activity of the VDR through regulation of the Vitamin D Metabolites] sallieq
@@ Line 69: / Line 69: @@
 interpreting the test results.
-//**The therapeutic target range**// for 25-D is 12ng/ml below which the immune system is fully functional. A 25-D above 25ng/ml will not be able to kill pathogenic bacteria. For 1,25-D the target is <20 pg/ml and is a measure of inflammation.  7
+//**The therapeutic target range**// for 25-D is 12ng/ml below which the immune system is fully functional. A 25-D above 25ng/ml will not be able to kill pathogenic bacteria. For 1,25-D the target is <20 pg/ml and is a measure of inflammation.  //7//
 Mucosal response and calcium/phosphorus absorption is dependent on a competent vitamin D receptor (VDR), and elevated 1,25(OH)2D reduces VDR
 competence. Thus, calcium and phosphorus absorption may be inhibited if VDR function is impaired by elevated 1,25(OH)2D. Measuring calcium is primarily affected by
-PTH status, not VDR competence.  9
+PTH status, not VDR competence.  //9//
 ==== Special Handling of the 1,25D Blood sample ====
@@ Line 92: / Line 92: @@
 ..is the body's first line of defense against, and non-specific way for responding to bacterial pathogens. Located in the nucleus of a variety of cells, the Vitamin D nuclear receptor (VDR) plays a crucial, often under-appreciated, role in the innate immune response.
-When functioning properly, the VDR transcribes between hundreds and thousands of genes including those for the proteins known as the antimicrobial peptides.   6
+When functioning properly, the VDR transcribes between hundreds and thousands of genes including those for the proteins known as the antimicrobial peptides.   //6//
-Antimicrobial peptides are the body's natural antibiotics, crucial for both prevention and clearance of infection. The VDR also expresses the TLR2 receptor, which is expressed on the surface of certain cells and recognizes foreign substances.   2
+Antimicrobial peptides are the body's natural antibiotics, crucial for both prevention and clearance of infection. The VDR also expresses the TLR2 receptor, which is expressed on the surface of certain cells and recognizes foreign substances.   //2//
 ==== The body controls activity of the VDR through regulation of the Vitamin D Metabolites ====
-Although early stage autoimmune disease often succumbs to antibiotic therapy, antibiotics appear to lose utility as disease progresses. Recent sequencing of microbial DNA has confirmed that some pathogens ensure their persistence by reducing expression of, and transcription by, the VDR nuclear receptor, which is at the heart of the human innate immune system.  8,   10
+Although early stage autoimmune disease often succumbs to antibiotic therapy, antibiotics appear to lose utility as disease progresses. Recent sequencing of microbial DNA has confirmed that some pathogens ensure their persistence by reducing expression of, and transcription by, the VDR nuclear receptor, which is at the heart of the human innate immune system. // 8,   10//
 Only in homo sapiens is the VDR responsible for expression of the Cathelicidin antimicrobial peptide, the primary defene of the intra-phagocytic innate immune system.

home/physicians/vitamin_d_leaflet.txt · Last modified: 09.14.2022 by 127.0.0.1