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home:physicians:vitamin_d_leaflet [06.11.2018] – [Therapeutic ranges for Immunostimulation, and to determine if active Immunosuppression is present] sallieq | home:physicians:vitamin_d_leaflet [06.11.2018] – [The body controls activity of the VDR through regulation of the Vitamin D Metabolites] sallieq | ||
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..is the body's first line of defense against, and non-specific way for responding to bacterial pathogens. Located in the nucleus of a variety of cells, the Vitamin D nuclear receptor (VDR) plays a crucial, often under-appreciated, | ..is the body's first line of defense against, and non-specific way for responding to bacterial pathogens. Located in the nucleus of a variety of cells, the Vitamin D nuclear receptor (VDR) plays a crucial, often under-appreciated, | ||
- | When functioning properly, the VDR transcribes between hundreds and thousands of genes including those for the proteins known as the antimicrobial peptides. | + | When functioning properly, the VDR transcribes between hundreds and thousands of genes including those for the proteins known as the antimicrobial peptides. |
- | Antimicrobial peptides are the body's natural antibiotics, | + | Antimicrobial peptides are the body's natural antibiotics, |
==== The body controls activity of the VDR through regulation of the Vitamin D Metabolites ==== | ==== The body controls activity of the VDR through regulation of the Vitamin D Metabolites ==== | ||
- | Although early stage autoimmune disease often succumbs to antibiotic therapy, antibiotics appear to lose utility as disease progresses. Recent sequencing of microbial DNA has confirmed that some pathogens ensure their persistence by reducing expression of, and transcription by, the VDR nuclear receptor, which is at the heart of the human innate immune system. | + | Although early stage autoimmune disease often succumbs to antibiotic therapy, antibiotics appear to lose utility as disease progresses. Recent sequencing of microbial DNA has confirmed that some pathogens ensure their persistence by reducing expression of, and transcription by, the VDR nuclear receptor, which is at the heart of the human innate immune system. |
Only in homo sapiens is the VDR responsible for expression of the Cathelicidin antimicrobial peptide, the primary defene of the intra-phagocytic innate immune system. | Only in homo sapiens is the VDR responsible for expression of the Cathelicidin antimicrobial peptide, the primary defene of the intra-phagocytic innate immune system. |