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home:physicians:vitamin_d_leaflet [06.11.2018] – [Therapeutic ranges for Immunostimulation, and to determine if active Immunosuppression is present] sallieq | home:physicians:vitamin_d_leaflet [06.26.2018] – [The body controls activity of the VDR through regulation of the Vitamin D Metabolites] sallieq | ||
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..is the body's first line of defense against, and non-specific way for responding to bacterial pathogens. Located in the nucleus of a variety of cells, the Vitamin D nuclear receptor (VDR) plays a crucial, often under-appreciated, | ..is the body's first line of defense against, and non-specific way for responding to bacterial pathogens. Located in the nucleus of a variety of cells, the Vitamin D nuclear receptor (VDR) plays a crucial, often under-appreciated, | ||
- | When functioning properly, the VDR transcribes between hundreds and thousands of genes including those for the proteins known as the antimicrobial peptides. | + | When functioning properly, the VDR transcribes between hundreds and thousands of genes including those for the proteins known as the antimicrobial peptides. |
- | Antimicrobial peptides are the body's natural antibiotics, | + | Antimicrobial peptides are the body's natural antibiotics, |
==== The body controls activity of the VDR through regulation of the Vitamin D Metabolites ==== | ==== The body controls activity of the VDR through regulation of the Vitamin D Metabolites ==== | ||
- | Although early stage autoimmune disease often succumbs to antibiotic therapy, antibiotics appear to lose utility as disease progresses. Recent sequencing of microbial DNA has confirmed that some pathogens ensure their persistence by reducing expression of, and transcription by, the VDR nuclear receptor, which is at the heart of the human innate immune system. | + | Although early stage autoimmune disease often succumbs to antibiotic therapy, antibiotics appear to lose utility as disease progresses. Recent sequencing of microbial DNA has confirmed that some pathogens ensure their persistence by reducing expression of, and transcription by, the VDR nuclear receptor, which is at the heart of the human innate immune system. |
- | Only in homo sapiens is the VDR responsible for expression of the Cathelicidin antimicrobial peptide, the primary | + | Only in homo sapiens is the VDR responsible for expression of the Cathelicidin antimicrobial peptide, the primary |
==== Humans Are Not Tall Mice Without Tails! ==== | ==== Humans Are Not Tall Mice Without Tails! ==== | ||
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Importantly, | Importantly, | ||
- | You cannot study the vitamin D receptor in mice, how it relates to the immune system, and expect it to translate to Homo sapiens. Whereas in man the VDR transcribes cathelicidin, | + | You cannot study the vitamin D receptor in mice, how it relates to the immune system, and expect it to translate to Homo sapiens. Whereas in man the VDR transcribes cathelicidin, |
In mice, there are other receptors, and other genes that do that. Even the higher primates do not emulate the cathelicidin innate immunity of Homo sapiens. | In mice, there are other receptors, and other genes that do that. Even the higher primates do not emulate the cathelicidin innate immunity of Homo sapiens. | ||
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Further, we note that characteristic modes of instability lie in the microwave frequency range, which is currently populated by cellphone and WiFi communication signals, and that the susceptibility is ligand dependent. | Further, we note that characteristic modes of instability lie in the microwave frequency range, which is currently populated by cellphone and WiFi communication signals, and that the susceptibility is ligand dependent. | ||
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