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home:physicians:vitamin_d_leaflet [06.11.2018] – [Humans Are Not Tall Mice Without Tails!] sallieq | home:physicians:vitamin_d_leaflet [09.14.2022] (current) – external edit 127.0.0.1 | ||
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- | ====== Testing | + | ====== Testing Vitamin D Metabolites ====== |
===== Inflammatory Markers Of Chronic Disease | ===== Inflammatory Markers Of Chronic Disease | ||
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disease, prevention of harmful supplementation, | disease, prevention of harmful supplementation, | ||
density and calcification risk. | density and calcification risk. | ||
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+ | see also Clinical Utility of Measurement of Vitamin D-Binding Protein and Calculation of Bioavailable Vitamin D in Assessment of Vitamin D Status | ||
==== Metabolism and Immunostimulation ==== | ==== Metabolism and Immunostimulation ==== | ||
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Although early stage autoimmune disease often succumbs to antibiotic therapy, antibiotics appear to lose utility as disease progresses. Recent sequencing of microbial DNA has confirmed that some pathogens ensure their persistence by reducing expression of, and transcription by, the VDR nuclear receptor, which is at the heart of the human innate immune system. // 8, 10// | Although early stage autoimmune disease often succumbs to antibiotic therapy, antibiotics appear to lose utility as disease progresses. Recent sequencing of microbial DNA has confirmed that some pathogens ensure their persistence by reducing expression of, and transcription by, the VDR nuclear receptor, which is at the heart of the human innate immune system. // 8, 10// | ||
- | Only in homo sapiens is the VDR responsible for expression of the Cathelicidin antimicrobial peptide, the primary | + | Only in homo sapiens is the VDR responsible for expression of the Cathelicidin antimicrobial peptide, the primary |
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==== Humans Are Not Tall Mice Without Tails! ==== | ==== Humans Are Not Tall Mice Without Tails! ==== | ||
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Importantly, | Importantly, | ||
- | You cannot study the vitamin D receptor in mice, how it relates to the immune system, and expect it to translate to Homo sapiens. Whereas in man the VDR transcribes cathelicidin, | + | You cannot study the vitamin D receptor in mice, how it relates to the immune system, and expect it to translate to Homo sapiens. Whereas in man the VDR transcribes cathelicidin, |
In mice, there are other receptors, and other genes that do that. Even the higher primates do not emulate the cathelicidin innate immunity of Homo sapiens. | In mice, there are other receptors, and other genes that do that. Even the higher primates do not emulate the cathelicidin innate immunity of Homo sapiens. | ||
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References: | References: | ||
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1. Marshall TG: Vitamin D discovery outpaces FDA decision making. | 1. Marshall TG: Vitamin D discovery outpaces FDA decision making. | ||
BioEssays. 2008 Feb; | BioEssays. 2008 Feb; | ||
- | http:// | + | https:// |
2. Proal AD, Albert PJ, Marshall TG: Dysregulation of the Vitamin D Nuclear | 2. Proal AD, Albert PJ, Marshall TG: Dysregulation of the Vitamin D Nuclear | ||
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3. Albert PJ, Proal AD, Marshall TG: Vitamin D: the alternative hypothesis. | 3. Albert PJ, Proal AD, Marshall TG: Vitamin D: the alternative hypothesis. | ||
Autoimmunity Reviews. 2009 Jul; | Autoimmunity Reviews. 2009 Jul; | ||
- | http:// | + | https:// |
4. Proal AD, Albert PJ, Marshall TG: Autoimmune disease in the era of the | 4. Proal AD, Albert PJ, Marshall TG: Autoimmune disease in the era of the | ||
Metagenome. Autoimmunity Reviews. 2009 Jul; | Metagenome. Autoimmunity Reviews. 2009 Jul; | ||
- | http:// | + | https:// |
5. Proal AD, Albert PJ, Marshall TG: Infection, Autoimmunity, | 5. Proal AD, Albert PJ, Marshall TG: Infection, Autoimmunity, | ||
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Further, we note that characteristic modes of instability lie in the microwave frequency range, which is currently populated by cellphone and WiFi communication signals, and that the susceptibility is ligand dependent. | Further, we note that characteristic modes of instability lie in the microwave frequency range, which is currently populated by cellphone and WiFi communication signals, and that the susceptibility is ligand dependent. | ||
- | Trevor | + | Trevor |
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+ | ==== in this section ==== | ||
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+ | {{tag> | ||
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+ | ==== Notes and comments ==== | ||
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