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home:protocol:immunopathology [08.28.2012] – [Immunopathology reveals disease] paulalberthome:protocol:immunopathology [10.13.2018] – [Related publications and presentations] sallieq
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 <blockquote>In our study, we offer the first direct evidence that limiting the immune response reduces the manifestations of rhinovirus infection. In our model, cold-induced asthma flare-ups were caused by the body's immune response to the virus, not the virus itself. Chemicals produced by the immune system inflame cells and tissues, causing asthma symptoms such as cough and wheeze. <blockquote>In our study, we offer the first direct evidence that limiting the immune response reduces the manifestations of rhinovirus infection. In our model, cold-induced asthma flare-ups were caused by the body's immune response to the virus, not the virus itself. Chemicals produced by the immune system inflame cells and tissues, causing asthma symptoms such as cough and wheeze.
  
-//**Marc B. Hershenson, M.D.,**  [[http://www.sciencedaily.com/releases/2011/06/110616081719.htm|ScienceDaily]]//</blockquote> +//**Marc B. Hershenson, M.D.,**  [[http://www.sciencedaily.com/releases/2011/06/110616081719.htm|ScienceDaily]]// June 17, 2011</blockquote> 
  
 Even though it was conducted in a murine model, this work is relevant as it strongly suggests that symptoms of infection are due not so much to the infection but the body's response to it. Even though it was conducted in a murine model, this work is relevant as it strongly suggests that symptoms of infection are due not so much to the infection but the body's response to it.
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 ===== Immune reconstitution inflammatory syndrome (IRIS)==== ===== Immune reconstitution inflammatory syndrome (IRIS)====
  
-Immune reconstitution inflammatory syndrome (IRIS) is a condition seen in some cases of AIDS often following the use of antiretroviral drugs, in which the immune system begins to recover, but then responds to a previously acquired opportunistic infection with an overwhelming inflammatory response that paradoxically makes the symptoms of infection worse.(({{pubmed>long:11997718}}))+During IRIS, HIV/AIDS patients experience the worsening or onset of systemic inflammatory clinical signs and symptoms following treatment with highly active antiretroviral therapy (HAART). This syndrome results when HAART allows for partial recovery of the immune response. This causes renewed and exuberant host immunological responses towards opportunistic infectious agents, agents that the host accumulated during prior periods of immunosuppression.(({{pubmed>long:20507930}})) 
 + 
 +A number of well-known readily cultured pathogens have been conclusively linked to IRIS: the herpes viruses, cytomegalovirus, hepatitis B and C, //M. tuberculosis//, //Mycobacterium avium// complex and //Cryptococcus neoformans//.(({{pubmed>long:17488505}})) However, many more microbes likely contribute to the reaction since AIDS clinicians do not yet have access to the metagenomic tools. Certainly, the existence of IRIS in culture-negative HAART patients suggests that more microbes may be present than the few that have already been isolated.(({{pubmed>long:19365271}})) 
 + 
 +Interestingly, patients experiencing IRIS often "develop" autoimmune conditions as a manifestation of immune restoration. These include sarcoidosis and other granulomatous reactions,(({{pubmed>long:10351953}})) (({{pubmed>long:10426909}})) diabetes mellitus, rheumatoid arthritis,(({{pubmed>long:12194745}})) systemic lupus erythematosus,(({{pubmed>long:9546531}})) Guillain–Barre syndrome,(({{pubmed>long:12715328}})) Graves disease(({{pubmed>long:11192862}})) and autoimmune thyroid disease.(({{pubmed>long:17488505}})) (({{pubmed>long:16325657}})) This suggests that these patients accumulated microbes that are directly involved in the pathogenesis of these disease states. 
 + 
 +In a 2009 study, Sun and Singh reviewed the existence of IRIS in non-HIV immunocompromised patients including  solid organ transplant recipients, women during the postpartum period, neutropenic patients, and tumor necrosis factor antagonist recipients.(({{pubmed>long:19483618}})) 
  
-In a 2009 study, Sun and Singh review the existence of IRIS in non-HIV immunocompromised patients including  solid organ transplant recipients, women during the postpartum period, neutropenic patients, and tumor necrosis factor antagonist recipients.(({{pubmed>long:19483618}})) 
 ===== Immunopathology reveals disease ===== ===== Immunopathology reveals disease =====
  
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 In observing a set of worsening symptoms, patients and clinicians may be tempted to assume that the disease itself is worsening. Even a small number of researchers are mistakenly convinced that antibiotics cause or exacerbate chronic disease. The best example of this may be so-called "minocycline-induced lupus."(({{pubmed>long:17366961}})) In fact, there is no reasonable mechanism, proven or theoretical, which explains how minocycline, the primary action of which is to block the 30s ribosome of bacteria, can cause lupus – or any other disease.(({{pubmed>long:17511865}})) Nor is there a mechanism by which olmesartan can cause porphyria cutanea tarda (a blood disorder) as was reported in a 2010 //Journal of the European Academy of Dermatology and Venereology// paper.(({{pubmed>long:20015057}})) In observing a set of worsening symptoms, patients and clinicians may be tempted to assume that the disease itself is worsening. Even a small number of researchers are mistakenly convinced that antibiotics cause or exacerbate chronic disease. The best example of this may be so-called "minocycline-induced lupus."(({{pubmed>long:17366961}})) In fact, there is no reasonable mechanism, proven or theoretical, which explains how minocycline, the primary action of which is to block the 30s ribosome of bacteria, can cause lupus – or any other disease.(({{pubmed>long:17511865}})) Nor is there a mechanism by which olmesartan can cause porphyria cutanea tarda (a blood disorder) as was reported in a 2010 //Journal of the European Academy of Dermatology and Venereology// paper.(({{pubmed>long:20015057}}))
  
-Edward L. Krawitt, M.D. has it right when he suggests the possibility that minocycline, an MP antibiotic, "unmasks" autoimmune hepatitis.(({{pubmed>long:16394302}})) +Edward L. Krawitt, M.D. has it right when he suggests the possibility that minocycline, "unmasks" autoimmune hepatitis.(({{pubmed>long:16394302}})) 
  
-In the same vein, a so-called [[home:mp:allergies|“allergic” reaction to minocycline]] or any of the other MP antibiotics is invariably due to the immunopathological response generated by taking olmesartan (Benicar) and antibiotics. +In the same vein, an “allergic” reaction to minocycline or any of the other antibiotics formerly used with Olmesartan was invariably due to the immunopathological response generated by taking olmesartan (Benicar) and antibiotics. 
  
 Some Marshall Protocol patients have reported that the treatment appears to clinically reveal markers of latent infections. Some Marshall Protocol patients have reported that the treatment appears to clinically reveal markers of latent infections.
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-{{tag>Science_behind_Protocol}}+{{tag>Science_behind_Protocol IP Microbes_in_the_human_body}}
 ===== Notes and comments ===== ===== Notes and comments =====
  
home/protocol/immunopathology.txt · Last modified: 09.14.2022 by 127.0.0.1
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