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home:protocol:mp_antibiotics [02.23.2011] – paulalberthome:protocol:mp_antibiotics [01.03.2012] – external edit 127.0.0.1
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 ===== Mechanisms of action ===== ===== Mechanisms of action =====
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 +Emerging research now suggests that antibiotics have much broader range of actions that once supposed.
  
 ^Name   ^Action(s) ^ ^Name   ^Action(s) ^
 |Minocycline    |interferes with bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome; may bind the PXR Nuclear Receptor; inhibits activity of caspase-3    |   |Minocycline    |interferes with bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome; may bind the PXR Nuclear Receptor; inhibits activity of caspase-3    |  
-|Azithromycin (Zithromax)     |interferes with bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome      |+|Azithromycin (Zithromax)     |interferes with bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome;  significantly inhibited expression of co-stimulatory molecules (CD40 and CD86) and major histocompatibility complex (MHC) class II by dendritic cells; reduces toll-like receptor 4 expression, interleukin-12 production and the allostimulatory capacity of dendritic cells(({{pubmed>long:22059997}})) |
 |Clindamycin   |interferes with bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome     | |Clindamycin   |interferes with bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome     |
 |Demeclocycline (Declomycin)  |interferes with bacterial protein synthesis by binding to the 30S and 50S subunit of the bacterial ribosome     |        |Demeclocycline (Declomycin)  |interferes with bacterial protein synthesis by binding to the 30S and 50S subunit of the bacterial ribosome     |       
 |Bactrim DS   |inhibits dihydropteroate synthase, an enzyme that allows bacteria to use folic acid      | |Bactrim DS   |inhibits dihydropteroate synthase, an enzyme that allows bacteria to use folic acid      |
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 ==== Inhibition of bacterial ribosome activity (minocycline, azithromycin, clindamycin, demeclocycline) ==== ==== Inhibition of bacterial ribosome activity (minocycline, azithromycin, clindamycin, demeclocycline) ====
  
home/protocol/mp_antibiotics.txt · Last modified: 09.14.2022 by 127.0.0.1
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