This shows you the differences between two versions of the page.
Both sides previous revisionPrevious revision | |||
home:protocol:mp_antibiotics [08.23.2014] – deemphasized antibiotics paulalbert | home:protocol:mp_antibiotics [09.14.2022] (current) – external edit 127.0.0.1 | ||
---|---|---|---|
Line 38: | Line 38: | ||
^Name | ^Name | ||
|Minocycline | |Minocycline | ||
- | |Azithromycin (Zithromax) //no longer recommended// | + | |Azithromycin (Zithromax) //no longer recommended// |
|Clindamycin | |Clindamycin | ||
|Demeclocycline (Declomycin) | |Demeclocycline (Declomycin) | ||
Line 58: | Line 58: | ||
The affinity (Kd) of minocycline for the bacteria' | The affinity (Kd) of minocycline for the bacteria' | ||
- | A recent paper has suggested that various tetracycline antibiotics including clindamycin activate the PXR.(({{pubmed> | + | A recent paper has suggested that various tetracycline antibiotics including clindamycin activate the PXR.(({{pmid> |
The conclusion of that paper is somewhat at odds with the //in silico// model produced by Trevor Marshall, PhD, from which he has concluded that of the tetracyclines, | The conclusion of that paper is somewhat at odds with the //in silico// model produced by Trevor Marshall, PhD, from which he has concluded that of the tetracyclines, | ||
Line 67: | Line 67: | ||
==== Inhibition of caspase-3 (minocycline) ==== | ==== Inhibition of caspase-3 (minocycline) ==== | ||
- | Caspase-3 is a protease, which breaks apart the VDR receptor structure and thus limits the ability of VDR to do gene transcription. Minocycline is known to inhibit Caspase-3 activation.(({{pubmed> | + | Caspase-3 is a protease, which breaks apart the VDR receptor structure and thus limits the ability of VDR to do gene transcription. Minocycline is known to inhibit Caspase-3 activation.(({{pmid> |
Line 74: | Line 74: | ||
--></ | --></ | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
- | ===== References ===== | + | ===== References =====</ |