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home:protocol:mp_antibiotics [08.23.2014] – deemphasized antibiotics paulalberthome:protocol:mp_antibiotics [09.14.2022] (current) – external edit 127.0.0.1
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 ^Name   ^Action(s) ^ ^Name   ^Action(s) ^
 |Minocycline    |interferes with bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome; may bind the PXR Nuclear Receptor; inhibits activity of caspase-3    |   |Minocycline    |interferes with bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome; may bind the PXR Nuclear Receptor; inhibits activity of caspase-3    |  
-|Azithromycin (Zithromax) //no longer recommended//     |interferes with bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome;  significantly inhibited expression of co-stimulatory molecules (CD40 and CD86) and major histocompatibility complex (MHC) class II by dendritic cells; reduces toll-like receptor 4 expression, interleukin-12 production and the allostimulatory capacity of dendritic cells(({{pubmed>long:22059997}})) |+|Azithromycin (Zithromax) //no longer recommended//     |interferes with bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome;  significantly inhibited expression of co-stimulatory molecules (CD40 and CD86) and major histocompatibility complex (MHC) class II by dendritic cells; reduces toll-like receptor 4 expression, interleukin-12 production and the allostimulatory capacity of dendritic cells(({{pmid>long:22059997}})) |
 |Clindamycin   |interferes with bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome     | |Clindamycin   |interferes with bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome     |
 |Demeclocycline (Declomycin)  |interferes with bacterial protein synthesis by binding to the 30S and 50S subunit of the bacterial ribosome     |        |Demeclocycline (Declomycin)  |interferes with bacterial protein synthesis by binding to the 30S and 50S subunit of the bacterial ribosome     |       
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 The affinity (Kd) of minocycline for the bacteria's 30S ribosome is not as high as one might otherwise expect based on its action. For this reason, it seems likely that minocycline may affect immune function in other ways. One possibility is the Pregnane X Nuclear Receptor (PXR). The affinity (Kd) of minocycline for the bacteria's 30S ribosome is not as high as one might otherwise expect based on its action. For this reason, it seems likely that minocycline may affect immune function in other ways. One possibility is the Pregnane X Nuclear Receptor (PXR).
  
-A recent paper has suggested that various tetracycline antibiotics including clindamycin activate the PXR.(({{pubmed>long:18505790}})) Whether that conclusion is confirmed by further research remains to be seen.+A recent paper has suggested that various tetracycline antibiotics including clindamycin activate the PXR.(({{pmid>long:18505790}})) Whether that conclusion is confirmed by further research remains to be seen.
  
 The conclusion of that paper is somewhat at odds with the //in silico// model produced by Trevor Marshall, PhD, from which he has concluded that of the tetracyclines, minocycline is the only one that activates the PXR.  The conclusion of that paper is somewhat at odds with the //in silico// model produced by Trevor Marshall, PhD, from which he has concluded that of the tetracyclines, minocycline is the only one that activates the PXR. 
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 ==== Inhibition of caspase-3 (minocycline) ==== ==== Inhibition of caspase-3 (minocycline) ====
  
-Caspase-3 is a protease, which breaks apart the VDR receptor structure and thus limits the ability of VDR to do gene transcription. Minocycline is known to inhibit Caspase-3 activation.(({{pubmed>long:15990464}}))(({{pubmed>long:16638021}}))+Caspase-3 is a protease, which breaks apart the VDR receptor structure and thus limits the ability of VDR to do gene transcription. Minocycline is known to inhibit Caspase-3 activation.(({{pmid>long:15990464}}))(({{pmid>long:16638021}}))
  
  
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 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
  
-===== References =====+===== References =====</nodisp> 
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