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home:publications:benediktsson_autoimmunity_2010 [06.14.2010]
paulalbert
home:publications:benediktsson_autoimmunity_2010 [01.03.2012]
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-====== Abstract - Bipolar disorders and autoimmune disease share a similar etiology====== 
  
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-**Type:** Conference presentation\\ 
-**Presenter:​** ​ Chris Benediktsson,​ Janet Raty, Trevor Marshall, PhD\\ 
-**Conference:​** ​ 7th International Congress on Autoimmunity\\ 
-**Location:​** Ljubljana, Slovenia\\ 
-**Date:​** ​ May 2010\\ 
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-===== Abstract ===== 
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-Since the mid 1800s we have known that some infectious agents can cause dramatic personality changes, for example in diseases such as syphilis, rabies, toxoplasmosis and neurologic lyme disease. Treatment was dominated for many years by psychological theorizing, much of it Freudian; biological approaches were essentially limited to genetics. Recently both persistent viruses and antibodies to pathogens have been detected in samples from patients with bipolar disease. “Autoantibodies” to brain proteins, nuclear material, and brain lipids, among others, have been detected in both schizophrenic and bipolar populations. Higher levels of interleukin (IL1, IL 2, IL 1 RA), CD 4, CD 8 and Th1 and Th2 cytokines have been found in bipolar patients before, during and after medical treatment, strongly suggesting that bipolar disorders and autoimmune disease share a similar etiology. 
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-We have been conducting an observational study since 2002 of a VDR agonist along with pulsed low dose antibiotics for treatment of chronic inflammatory diseases. Intriguingly,​ many of the study subjects had initially reported comorbid symptoms of cognitive impairment, including brain fog and major depression, consistent with advanced chronic disease. Four patients, who had noted prior diagnoses of bipolar disorder 1 and II, reported significant improvement in bipolar symptoms after therapy. The improvement in mental function was concurrent with improvements in the symptoms of the comorbid autoimmune disease. This is consistent with a shared etiology and strongly suggestive of the involvement of bacterial pathogens. 
home/publications/benediktsson_autoimmunity_2010.txt · Last modified: 01.03.2012 (external edit)
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