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- ​====== Paper - Vitamin D metabolites as clinical markers in autoimmune and chronic disease ​ ====== 
-**Type:** Paper\\ 
-**Authors:​** ​ Greg Blaney, MD, Paul J. Albert, ​ Amy D. Proal\\ 
-**Publication:​** ​ //Annals of the New York Academy of Sciences//​\\ 
-**Citation:​** ​ {{pubmed>​long:​19758177}}\\ 
-**See also:** [[http://​autoimmunityResearch.org/​preprints/​BlaneyAnnals2009Preprint.pdf|Pre-print]] 
-===== Abstract ===== 
-Recent research has implicated vitamin D deficiency (serum levels of 25-hydroxyvitamin D <​50nmol/​L) with a number of chronic conditions including autoimmune conditions such as multiple sclerosis, lupus, psoriasis and chronic conditions such as osteoporosis,​ osteoarthritis,​ metabolic syndrome, fibromyalgia and chronic fatigue syndrome. It has been assumed that low levels of 25-hydroxyvitamin D (25-D) accurately indicate vitamin D storage and vitamin D receptor (VDR) mediated control of calcium metabolism and innate immunity. To evaluate this assumption, 25-D and 1,​25-dihydroxyvitamin D3 (1,25-D) levels were measured in 100 Canadian patients with these conditions. Additionally,​ other inflammatory markers (CK, CRP) were measured. Results showed a strong positive association between these autoimmune conditions and levels of 1,25-D >110 pmol/L. However, there was little association with vitamin D deficiency or the other inflammatory markers. These findings support the use of 1,25-D as a clinical marker in autoimmune conditions. It also suggests either a disruption of the controlling cytochrome P450 enzymes and/or reduced VDR responsiveness in these conditions. Finally, the results challenge the assumption that measurement of 25-D is an accurate index of vitamin D metabolism. 
-{{tag>​papers Greg_Blaney_MD Paul_Albert Amy_Proal 2009}} 
home/publications/blaney_annals_2009.txt · Last modified: 01.03.2012 (external edit)
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