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Well, with this in mind, it's entirely possible that in autoimmune disease the antibodies are not being created in response to self but are instead being produced in response to these pathogens. | Well, with this in mind, it's entirely possible that in autoimmune disease the antibodies are not being created in response to self but are instead being produced in response to these pathogens. | ||
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====#6 Gestational age at delivery as a function of bacterial rDNA concentrates in the amniotic fluid==== | ====#6 Gestational age at delivery as a function of bacterial rDNA concentrates in the amniotic fluid==== | ||
- | Even tissues with the highest reputation for sterility such as, let's say, the amniotic fluid, are actually filled with a diversity of bacteria. In 2008 DiGullio and Relman at Stanford published a paper showing the presence of 18 different bacterial taxa in the amniotic fluid.(({{pubmed> | + | Well, even tissues with the highest reputation for sterility such as, let's say, the amniotic fluid, are actually filled with a diversity of bacteria. In 2008 DiGullio and Relman at Stanford published a paper showing the presence of 18 different bacterial taxa in the amniotic fluid.(({{pubmed> |
====#7 How does chronic disease develop? | ====#7 How does chronic disease develop? | ||
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====#8 Nuclear receptors down regulated upon infection==== | ====#8 Nuclear receptors down regulated upon infection==== | ||
- | Take, for example, the Vitamin D Receptor or VDR - a type 1 nuclear receptor. Well, it turns out that viruses like Epstein-Barr Virus and bacteria like // | + | Take, for example, the Vitamin D Receptor or VDR - it' |
====#9 The Vitamin D Receptor (VDR)==== | ====#9 The Vitamin D Receptor (VDR)==== | ||
- | Why the VDR? Well, colloquially speaking, the VDR serves as a " | + | So, basically - you might ask, why the VDR? Well, colloquially speaking, the VDR serves as a " |
====#10 HIV and Borrelia burgdorferi==== | ====#10 HIV and Borrelia burgdorferi==== | ||
- | Note that HIV persists in the same fashion. It completely overtakes the VDR in order to transcribe its own genome.(({{pubmed> | + | And note that HIV persists in the same fashion. It completely overtakes the VDR in order to transcribe its own genome.(({{pubmed> |
- | This is such a logical survival mechanism on the part of these microbes that it is almost certain other less well-studied microbes have also evolved to slow VDR activity, or the activity of other receptors involved in controlling the immune response. | + | So - this is such a logical survival mechanism on the part of these microbes that it' |
====#11 Successive infection==== | ====#11 Successive infection==== | ||
- | Well, these persistence mechanisms result in a snowball effect. When the immune system slows, and a person acquires one pathogen, then it becomes easier to acquire another pathogen. | + | Well, these persistence mechanisms result in a snowball effect. When the immune system slows, and a person acquires one pathogen, then it becomes easier |
In the context of successive infection, an inflammatory disease state appears to result from the combined pathogenicity of the sum of microbes that any one person accumulates over the course of a lifetime. As human genes are upregulated or downregulated by components of these microbes, the human body shifts further and further away from its natural state of homeostasis. | In the context of successive infection, an inflammatory disease state appears to result from the combined pathogenicity of the sum of microbes that any one person accumulates over the course of a lifetime. As human genes are upregulated or downregulated by components of these microbes, the human body shifts further and further away from its natural state of homeostasis. | ||
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====#12 Epstein-Barr Virus (EBV)==== | ====#12 Epstein-Barr Virus (EBV)==== | ||
- | So, for example, over the past years, Epstein-Barr Virus has been detected in so many different proportions in so many disease states. | + | So, for example, over the past years, Epstein-Barr Virus has been detected in so many different proportions in so many disease states. |
====#13 Pathogens, aka " | ====#13 Pathogens, aka " | ||
- | With this in mind, a "one microbe/one disease" | + | With this in mind, a "one microbe/one disease" |
====#14 Co-morbidities among inflammatory diagnoses==== | ====#14 Co-morbidities among inflammatory diagnoses==== | ||
- | Well, it may also not be by accident that the uniqueness with which a patients' | + | Well, it may also not be by accident that the uniqueness with which a patients' |
====#15 Select bacterial genera detected in commonly smoked cigarettes==== | ====#15 Select bacterial genera detected in commonly smoked cigarettes==== | ||