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Take, for example, the Vitamin D Receptor or VDR - it's a type 1 nuclear receptor. Well, it turns out that viruses like Epstein-Barr Virus and bacteria like // | Take, for example, the Vitamin D Receptor or VDR - it's a type 1 nuclear receptor. Well, it turns out that viruses like Epstein-Barr Virus and bacteria like // | ||
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====#9 The Vitamin D Receptor (VDR)==== | ====#9 The Vitamin D Receptor (VDR)==== | ||
- | Why the VDR? Well, colloquially speaking, the VDR serves as a " | + | So, basically - you might ask, why the VDR? Well, colloquially speaking, the VDR serves as a " |
====#10 HIV and Borrelia burgdorferi==== | ====#10 HIV and Borrelia burgdorferi==== | ||
- | Note that HIV persists in the same fashion. It completely overtakes the VDR in order to transcribe its own genome.(({{pubmed> | + | And note that HIV persists in the same fashion. It completely overtakes the VDR in order to transcribe its own genome.(({{pubmed> |
- | This is such a logical survival mechanism on the part of these microbes that it is almost certain other less well-studied microbes have also evolved to slow VDR activity, or the activity of other receptors involved in controlling the immune response. | + | So - this is such a logical survival mechanism on the part of these microbes that it' |
====#11 Successive infection==== | ====#11 Successive infection==== | ||
- | Well, these persistence mechanisms result in a snowball effect. When the immune system slows, and a person acquires one pathogen, then it becomes easier to acquire another pathogen. | + | Well, these persistence mechanisms result in a snowball effect. When the immune system slows, and a person acquires one pathogen, then it becomes easier |
In the context of successive infection, an inflammatory disease state appears to result from the combined pathogenicity of the sum of microbes that any one person accumulates over the course of a lifetime. As human genes are upregulated or downregulated by components of these microbes, the human body shifts further and further away from its natural state of homeostasis. | In the context of successive infection, an inflammatory disease state appears to result from the combined pathogenicity of the sum of microbes that any one person accumulates over the course of a lifetime. As human genes are upregulated or downregulated by components of these microbes, the human body shifts further and further away from its natural state of homeostasis. | ||
And, infected cells increasingly struggle to correctly produce human metabolites in the face of all the proteins and enzymes that are being created by the pathogenic microbes. So, | And, infected cells increasingly struggle to correctly produce human metabolites in the face of all the proteins and enzymes that are being created by the pathogenic microbes. So, | ||
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====#12 Epstein-Barr Virus (EBV)==== | ====#12 Epstein-Barr Virus (EBV)==== | ||