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home:publications:proal_autoimmunity_2010 [06.15.2010] – marysuehome:publications:proal_autoimmunity_2010 [06.15.2010] – marysue
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 So - this is such a logical survival mechanism on the part of these microbes that it's almost certain that other less well-studied microbes have also evolved to slow VDR activity, or the activity of other receptors involved in controlling the immune response. So - this is such a logical survival mechanism on the part of these microbes that it's almost certain that other less well-studied microbes have also evolved to slow VDR activity, or the activity of other receptors involved in controlling the immune response.
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 ====#11 Successive infection==== ====#11 Successive infection====
  
-Well, these persistence mechanisms result in a snowball effect. When the immune system slows, and a person acquires one pathogen, then it becomes easier to acquire another pathogen.  Then the immune system acquires another pathogen.  These pathogens - they can each slow the immune system in turn. They can be viral, bacterial, fungal... and so on and so on. And this process is referred to as successive infection.+Well, these persistence mechanisms result in a snowball effect. When the immune system slows, and a person acquires one pathogen, then it becomes easier for them to acquire yet another pathogen.  And the immune system then acquires yet another pathogen.  And these pathogens each slow the immune system in turn. And the pathogens - they can be viral, fungal, bacterial... and so on and so on. And this process is referred to as successive infection.
  
 In the context of successive infection, an inflammatory disease state appears to result from the combined pathogenicity of the sum of microbes that any one person accumulates over the course of a lifetime. As human genes are upregulated or downregulated by components of these microbes, the human body shifts further and further away from its natural state of homeostasis. In the context of successive infection, an inflammatory disease state appears to result from the combined pathogenicity of the sum of microbes that any one person accumulates over the course of a lifetime. As human genes are upregulated or downregulated by components of these microbes, the human body shifts further and further away from its natural state of homeostasis.
  
 And, infected cells increasingly struggle to correctly produce human metabolites in the face of all the proteins and enzymes that are being created by the pathogenic microbes. So, eventually, people either start to develop an inflammatory diagnosis such as one of the "autoimmune" diseases, or they simply begin to present with aches and pains and other symptoms of what is often deemed "normal" aging. And, infected cells increasingly struggle to correctly produce human metabolites in the face of all the proteins and enzymes that are being created by the pathogenic microbes. So, eventually, people either start to develop an inflammatory diagnosis such as one of the "autoimmune" diseases, or they simply begin to present with aches and pains and other symptoms of what is often deemed "normal" aging.
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 ====#12 Epstein-Barr Virus (EBV)==== ====#12 Epstein-Barr Virus (EBV)====
  
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