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home:publications:proal_autoimmunity_2010 [06.15.2010] marysuehome:publications:proal_autoimmunity_2010 [06.15.2010] marysue
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 So, for example, over the past years, Epstein-Barr Virus has been detected in so many different proportions in so many disease states.  Here's just a sample of different diseases that've been associated with EBV. And for almost the last century, these results have served as the source of confusion.  But, if we view them through the lens of metagenomics and in the context of successive infection they make sense! Epstein-Barr Virus is just one component of a mix. In some cases it could be a precipitating factor for an autoimmune disease condition. Or, in other cases, it's just a pathogen that's acquired later on in the disease process, when the body's already dealing with the widespread immunsuppression that can be caused by any of the hundreds of bacterial pathogens that accumulate in the body. And we now understand that by altering nuclear receptor activity, viruses can aid the survival of bacteria and vice versa.  So, for example, over the past years, Epstein-Barr Virus has been detected in so many different proportions in so many disease states.  Here's just a sample of different diseases that've been associated with EBV. And for almost the last century, these results have served as the source of confusion.  But, if we view them through the lens of metagenomics and in the context of successive infection they make sense! Epstein-Barr Virus is just one component of a mix. In some cases it could be a precipitating factor for an autoimmune disease condition. Or, in other cases, it's just a pathogen that's acquired later on in the disease process, when the body's already dealing with the widespread immunsuppression that can be caused by any of the hundreds of bacterial pathogens that accumulate in the body. And we now understand that by altering nuclear receptor activity, viruses can aid the survival of bacteria and vice versa. 
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 ====#13 Pathogens, aka "rascals"==== ====#13 Pathogens, aka "rascals"====
  
-With this in mind, a "one microbe/one disease" paradigm is no longer viable and treatments for autoimmune disease that aim to eradicate only a single microbe - such as say, our purple friend here (EBV) - will at best succeed in only reversing a very small part of the overall disease process.+With this in mind, a "one microbe/one disease" paradigm is no longer viable and treatments for autoimmune disease that aim to eradicate only a single microbe - let'say, only our purple friend here (EBV) - will at best succeed in only reversing a very small part of the overall disease process.
 ====#14 Co-morbidities among inflammatory diagnoses==== ====#14 Co-morbidities among inflammatory diagnoses====
  
-Well, it may also not be by accident that the uniqueness with which a patients' autoimmune disease symptoms develop parallels the incredible diversity of the pathogens that can persist in the human body. The following wheel shows how truly related chronic diseases are. Each “spoke” on the wheel represents a published study that's shown a significant statistical relationship between patients suffering from one disease and the next. And that is a lot of comorbidity and a lot of symptom overlap.+Well, it may also not be by accident that the uniqueness with which a patients' autoimmune symptoms develop parallels the incredible diversity of the pathogens that can persist in the human body. The following wheel shows how truly related chronic diseases are. Each “spoke” on the wheel represents a published study that's shown a significant statistical relationship between patients suffering from one disease and the next. And that is a lot of comorbidity and a lot of symptom overlap. 
 ====#15 Select bacterial genera detected in commonly smoked cigarettes==== ====#15 Select bacterial genera detected in commonly smoked cigarettes====
  
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