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--- home:publications:proal_autoimmunity_reviews_2009 [10.24.2009] – external edit 127.0.0.1
+++ home:publications:proal_autoimmunity_reviews_2009 [11.11.2009] – paulalbert
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 **See also:** [[http://AutoimmunityResearch.org/transcripts/AR-Proal-Metagenome.pdf|Preprint]] (full text)\\
 **Notes:** Paper based on [[home:publications:proal_congress_on_autoimmunity_2008|presentation]] given at [[http://www.kenes.com/autoimmunity/|6th International Congress on Autoimmunity]], Porto, Portugal, September 2008
+**Faculty of 1000 mention:** Dr. Steven Witkin writing in the prestigious literary awareness tool, [[http://www.f1000biology.com/browse/|Faculty of 1000]] rated the Proal //et al.// paper a "must read," saying in part:
+<blockquote>The clear message of this article is that molecular genetic studies of
+diseases must include analysis of resident bacterial genomes and not focus
+solely on the human genome. The observations presented in this review
+are thought-provoking and offer new ways of thinking about the origin of
+diseases and possible novel treatments.
+The essence of this eye-opening article is that 90% of the cells in the
+human body are bacterial, that bacterial genomes are expressed in humans
+and that they have profound positive or negative influences on health.
+Compelling evidence is presented that humans are "superorganisms" whose
+molecular functions result from the sum of interactions between the human
+genome and a multitude of microbial genomes. The advantages of bacterial
+colonization and its profound influence on the diversity of the human
+metagenome are emphasized. The human genome is composed of about
+,000 genes, while the endogenous microbial flora contribute millions of
+genes. In addition, transcription of the human genome is altered by the
+presence or absence of bacterial products. Differences in bacterial
+colonization account for individual variations in gene expression. Lastly, the
+potential pivotal role of endogenous microbial genomes on the induction and
+persistence of autoimmune disease is emphasized.
+</blockquote>
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 {{tag>papers Trevor_Marshall_PhD Paul_Albert Amy_Proal 2009}}

home/publications/proal_autoimmunity_reviews_2009.txt · Last modified: 09.14.2022 by 127.0.0.1