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home:symptoms:grayhair [02.18.2019] – [Evidence of infectious cause] sallieqhome:symptoms:grayhair [09.14.2022] (current) – external edit 127.0.0.1
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 ===== Introduction ===== ===== Introduction =====
  
-Hair graying, also known as achromotrichia, is the most obvious sign of aging in humans. Change in hair color occurs when melanin ceases to be produced in the hair root and new hairs grow in without pigment. The stem cells at the base of hair follicles produce melanocytes, the cells that produce and store pigment in hair and skin. The death of the melanocyte stem cells causes the onset of graying.(({{pubmed>long:15618488}}))+Hair graying, also known as achromotrichia, is the most obvious sign of aging in humans. Change in hair color occurs when melanin ceases to be produced in the hair root and new hairs grow in without pigment. The stem cells at the base of hair follicles produce melanocytes, the cells that produce and store pigment in hair and skin. The death of the melanocyte stem cells causes the onset of graying.(({{pmid>long:15618488}}))
  
 Hair loss and hair color loss is very common in Th1 disease (it is made even worse by medications such as prednisone). Hair loss and hair color loss is very common in Th1 disease (it is made even worse by medications such as prednisone).
  
  
-For most researchers at least, the mechanisms which ultimately drive the process are largely unknown,(({{pubmed>long:15618488}})) However, there is reason to believe that the decline in melanin production by melanocyte stem cells may be due to an inflammatory process driven by the Th1 pathogens.+For most researchers at least, the mechanisms which ultimately drive the process are largely unknown,(({{pmid>long:15618488}})) However, there is reason to believe that the decline in melanin production by melanocyte stem cells may be due to an inflammatory process driven by the Th1 pathogens.
  
 One important factor in understanding why hair turns gray may prove to be activity to the Vitamin D Receptor (VDR), a receptor which is responsible for mounting an immune response to pathogenic bacteria. One of the many genes the Receptor transcribes is for hair follicles. One important factor in understanding why hair turns gray may prove to be activity to the Vitamin D Receptor (VDR), a receptor which is responsible for mounting an immune response to pathogenic bacteria. One of the many genes the Receptor transcribes is for hair follicles.
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 <blockquote>VDR expression in the epidermal component of the hair follicle, the keratinocyte, is critical for maintenance of the hair cycle.  <blockquote>VDR expression in the epidermal component of the hair follicle, the keratinocyte, is critical for maintenance of the hair cycle. 
  
- //**Kristi Skorija,** et al.// (({{pubmed>long:15591533}}))+ //**Kristi Skorija,** et al.// (({{pmid>long:15591533}}))
 </blockquote> </blockquote>
  
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   * **[[home:pathogenesis:th1spectrum|Comorbidities with other inflammatory conditions]]** – According to observational studies, patients suffering from known inflammatory diseases are somewhat more likely to get gray hair and vise-versa. This suggests some kind of shared pathology.   * **[[home:pathogenesis:th1spectrum|Comorbidities with other inflammatory conditions]]** – According to observational studies, patients suffering from known inflammatory diseases are somewhat more likely to get gray hair and vise-versa. This suggests some kind of shared pathology.
-    * **Heart attack: (myocardial infarction)** – After statistical adjustment for possible confounders, one research team found a correlation between graying of the hair, facial wrinkling, and frontoparietal baldness and crown-top baldness and myocardial infarction in men.(({{pubmed>long:7484729}})) The relative risk was greater for men with completely gray hair as compared to men with moderately gray hair. Men who had completely gray hair had approximately double the risk of heart attack as compared to men with no gray hair. A similar although weaker and not statistically significant trend was seen in women.  +    * **Heart attack: (myocardial infarction)** – After statistical adjustment for possible confounders, one research team found a correlation between graying of the hair, facial wrinkling, and frontoparietal baldness and crown-top baldness and myocardial infarction in men.(({{pmid>long:7484729}})) The relative risk was greater for men with completely gray hair as compared to men with moderately gray hair. Men who had completely gray hair had approximately double the risk of heart attack as compared to men with no gray hair. A similar although weaker and not statistically significant trend was seen in women.  
-    * **Vitilligo** – Patients with vitiligo frequently have premature gray hair.(({{pubmed>long:7633817}})) Vitilligo, a common autoimmune condition in which patients lose skin pigment, is often treated with immunosuppressive measures such as phototherapy.(({{pubmed>long:17524129}})) +    * **Vitilligo** – Patients with vitiligo frequently have premature gray hair.(({{pmid>long:7633817}})) Vitilligo, a common autoimmune condition in which patients lose skin pigment, is often treated with immunosuppressive measures such as phototherapy.(({{pmid>long:17524129}})) 
 ===== Patients experiences ===== ===== Patients experiences =====
  
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 I have very little gray hair and the new hair that is growing in is black rather than gray. I have very little gray hair and the new hair that is growing in is black rather than gray.
  
- //**Sue Andorn,**// [[http://bacteriality.com/2007/09/22/interview3/|Bacteriality interview]]+ //**Sue Andorn,**// [[https://bacteriality.com/2007/09/22/interview3/|Bacteriality interview]]
 </blockquote> </blockquote>
  
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 {{tag>symptoms arrange}} {{tag>symptoms arrange}}
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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 -Also, have a “symptom” to take off my list, which I never had put on the list since I thought it was normal. Last month when it was time to do the roots of my hair to cover grey, I couldn't see any grey. I thought I was losing my ability to see color. Great. So, I finally had someone else look at it for me, and they could not see any grey either! Also, the non-grey roots which had become increasingly dark the past few years, were close to my normal blonde color, they were a dirty blonde, I could barely tell the difference from them and the color I've been using. I am keeping my eyes open for the next time around, need to double check and see if it happens again! ~CFSgirl  -Also, have a “symptom” to take off my list, which I never had put on the list since I thought it was normal. Last month when it was time to do the roots of my hair to cover grey, I couldn't see any grey. I thought I was losing my ability to see color. Great. So, I finally had someone else look at it for me, and they could not see any grey either! Also, the non-grey roots which had become increasingly dark the past few years, were close to my normal blonde color, they were a dirty blonde, I could barely tell the difference from them and the color I've been using. I am keeping my eyes open for the next time around, need to double check and see if it happens again! ~CFSgirl 
-===== References =====+===== References =====</nodisp> 
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