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home:symptoms:muscle_bone [01.16.2019] – [Research] sallieqhome:symptoms:muscle_bone [09.14.2022] (current) – external edit 127.0.0.1
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- In the context of muscle aging, it is important to remember that it is not just a decline in muscle mass which contributes to the deterioration of muscle function. Other factors underpinning muscle quality come into play, including muscle composition, aerobic capacity and metabolism, fatty infiltration, insulin resistance, fibrosis and neural activation. Genetic, developmental, endocrine and lifestyle factors, such as physical activity, smoking and poor diet have dual effects on both muscle and bone mass in later life and these will be reviewed here.   (({{pubmed>long:25820482}}))   + In the context of muscle aging, it is important to remember that it is not just a decline in muscle mass which contributes to the deterioration of muscle function. Other factors underpinning muscle quality come into play, including muscle composition, aerobic capacity and metabolism, fatty infiltration, insulin resistance, fibrosis and neural activation. Genetic, developmental, endocrine and lifestyle factors, such as physical activity, smoking and poor diet have dual effects on both muscle and bone mass in later life and these will be reviewed here.   (({{pmid>long:25820482}}))   
  
-Muscle wasting occurs in a variety of conditions, including both genetic diseases, such as muscular dystrophies, and acquired disorders, ranging from muscle disuse to cancer cachexia, from heart failure to aging sarcopenia. In most of these conditions, the loss of muscle tissue is not homogeneous, but involves specific muscle groups (({{pubmed>long:23702032}})) +Muscle wasting occurs in a variety of conditions, including both genetic diseases, such as muscular dystrophies, and acquired disorders, ranging from muscle disuse to cancer cachexia, from heart failure to aging sarcopenia. In most of these conditions, the loss of muscle tissue is not homogeneous, but involves specific muscle groups (({{pmid>long:23702032}})) 
  
-  (({{pubmed>long:000}}))  
  
-Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation.  (({{pubmed>long:30639055}})) +Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation.  (({{pmid>long:30639055}})) 
      
-Age related changes of the motor excitabilities and central and peripheral muscle strength. The middle-aged group had lower MVC and twitch force of quadriceps, but not VA, than young group. No between group differences were found in fatigue indexes.    (({{pubmed>long:30640164}})) +Age related changes of the motor excitabilities and central and peripheral muscle strength. The middle-aged group had lower MVC and twitch force of quadriceps, but not VA, than young group. No between group differences were found in fatigue indexes.    (({{pmid>long:30640164}})) 
          
 Active pharmaceuticals continue to be identified in dietary supplements.... Active pharmaceuticals continue to be identified in dietary supplements....
-The drug ingredients in these dietary supplements have the potential to cause serious adverse health effects owing to accidental misuse, overuse, or interaction with other medications, underlying health conditions, or other pharmaceuticals within the supplement.     (({{pubmed>long:30646238}})) +The drug ingredients in these dietary supplements have the potential to cause serious adverse health effects owing to accidental misuse, overuse, or interaction with other medications, underlying health conditions, or other pharmaceuticals within the supplement.     (({{pmid>long:30646238}})) 
  
 ===== Connective tissue ===== ===== Connective tissue =====
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 Trigger thumbs are like trigger fingers–they literally get stuck in a certain position. This comes from inflammation involving the tendon. In my case, my thumbs started to feel “strange” and weak. They sometimes tingled and/or ached. When I would bend them after several months of the above, I would feel a snap or a pop. Finally, one became fixed in a bent position and the other in a straight position. The swelling and pain intensified throughout this time in my thumbs and the surrounding area in my palm.</blockquote>  Trigger thumbs are like trigger fingers–they literally get stuck in a certain position. This comes from inflammation involving the tendon. In my case, my thumbs started to feel “strange” and weak. They sometimes tingled and/or ached. When I would bend them after several months of the above, I would feel a snap or a pop. Finally, one became fixed in a bent position and the other in a straight position. The swelling and pain intensified throughout this time in my thumbs and the surrounding area in my palm.</blockquote> 
  
 +==== Poor digestion ====
 +
 +can cause muscle wasting, among other symptoms.  Some people find that prolonged use of Olmesartan can affect absorption of nutrients. Consult your doctor about sufficiency of protein in blood circulation.
 ==== Issues in pain management ==== ==== Issues in pain management ====
  
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 ===== Vitamin D and activity ===== ===== Vitamin D and activity =====
  
-Findings suggest that vitamin D supplementation does not prevent fractures or falls, or have clinically meaningful effects on bone mineral density. There were no differences between the effects of higher and lower doses of vitamin D. There is little justification to use vitamin D supplements to maintain or improve musculoskeletal health. This conclusion should be reflected in clinical guidelines.   (({{pubmed>long:30293909}})) +Findings suggest that vitamin D supplementation does not prevent fractures or falls, or have clinically meaningful effects on bone mineral density. There were no differences between the effects of higher and lower doses of vitamin D. There is little justification to use vitamin D supplements to maintain or improve musculoskeletal health. This conclusion should be reflected in clinical guidelines.   (({{pmid>long:30293909}})) 
  
 ===== Member posts ===== ===== Member posts =====
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 I am now in phase 3 and have been on MP for 2.5 years. I did have 1 prednisone shot in my finger but that was a very long time ago. As I have progressed on MP I have no pain in my finger anymore and it is totally functional. No stiffness either. Even my erythema in my palms has dramatically improved. //Debbie y  June 2006// </blockquote> I am now in phase 3 and have been on MP for 2.5 years. I did have 1 prednisone shot in my finger but that was a very long time ago. As I have progressed on MP I have no pain in my finger anymore and it is totally functional. No stiffness either. Even my erythema in my palms has dramatically improved. //Debbie y  June 2006// </blockquote>
 +
 +
 +<blockquote> If I haven't mentioned it before, the bursitis in the right shoulder is gone, except for a minor discomfort when sleeping on that side.
 +//MrsKeeper// </blockquote>
  
 <blockquote>one of my early herx's was trigger finger acting up. I have had the symptoms of carpal tunnel for years with the peripheral neuropathy that has not gotten any worse on MP, a slight bit better. Both my mom and friend Rose (both on MP) have had surgery on hands, and Rose on her feet too. I feel certain TH1 activity is related to these problems. I think the MP will cut 'em off at the pass and I will avoid carpal tunnel surgery! //P.B.// </blockquote> <blockquote>one of my early herx's was trigger finger acting up. I have had the symptoms of carpal tunnel for years with the peripheral neuropathy that has not gotten any worse on MP, a slight bit better. Both my mom and friend Rose (both on MP) have had surgery on hands, and Rose on her feet too. I feel certain TH1 activity is related to these problems. I think the MP will cut 'em off at the pass and I will avoid carpal tunnel surgery! //P.B.// </blockquote>
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 After one year on the Marshall Protocol, my shoulder was painfree and I had 100% mobility in that joint without any special exercises and complete resolution of pain. I suggest continue with PT, pain meds as needed and the MP.  and avoiding surgery. //Meg// </blockquote> After one year on the Marshall Protocol, my shoulder was painfree and I had 100% mobility in that joint without any special exercises and complete resolution of pain. I suggest continue with PT, pain meds as needed and the MP.  and avoiding surgery. //Meg// </blockquote>
 +
 +
 +<blockquote> Both my wife and I had frozen shoulders. Mine reacted strongly to Phase 3 meds in terms of herx, so ............ to the MP.
 +
 +Suggesting that 'frozen shoulder' is infectious might not go over well; but you can point to success here. I haven't quite got to 100% like Meg, but there is only an infrequent twinge now and again to remind me that I should exercise a bit more.
 +
 +//Chris & PTMKaren//</blockquote>
  
 <blockquote>One therapy, years later, that felt wonderful was in a heated pool with a physical therapist at a rehab center.  My muscles responded very quickly to that treatment, and being able to exercise and see the progress gave me an emotional boost.  <blockquote>One therapy, years later, that felt wonderful was in a heated pool with a physical therapist at a rehab center.  My muscles responded very quickly to that treatment, and being able to exercise and see the progress gave me an emotional boost. 
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-{{tag>symptoms arrange}}+{{tag>symptoms }}
  
  
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 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
 //replaced out of order in out of view section// //replaced out of order in out of view section//
-Family Practice.com. New realities in pain management issues. Available at: http://www.familypractice.com/lectures/pain2/lecture_ mccarberg_text_frame.htm\Familypractice. Accessed on April 21, 2003. Family Practice.com. New realities in pain management issues. Available at: http://www.familypractice.com/ lectures/pain2/lecture_marcus_text_frame.htm\Familypractice. Accessed on April 21, 2003. Medscape. Barriers to effective pain management. Available at: http://www.medscape.com/viewarticle/405853_3\Medscape. Accessed on April 21, 2003. Pain and Policies Study Group, University of Wisconsin. Regulatory systems and pain management. Available at: http://www.medsch.wisc.edu/painpolicy/eguide2000/text_version/appendix_b.html\Medsch. Accessed on April 21, 2003. Pain and Policies Study Group, University of Wisconsin. Are intractable pain treatment acts what we need? Available at: http://www.medsch.wisc.edu/ painpolicy/eguide2000/text_version/ appendix_d.html\Medsch. Accessed on April 21, 2003. DrugTopics.com. Pain management regulation. Available at: http://www.drugtopics.com/be_core/ content/ journals/d/data/2003/0407/show_article.jsp?filename=dce04a2003.html\Drugtopics. Accessed on April 21, 2003. RxList. Description of diclofenac and misoprostol. Available at: http://www.rxlist.com/cgi/generic2/ arthrotec.htm\Rxlist. Accessed on April 21, 2003. Doctor’s Guide. FDA approves once-daily Avinza (extended release morphine) for chronic, moderate-to-severe pain (March 21, 2001). Available at: http://www.docguide.com/ news/content.nsf/news/ 8525697700573E1885256B830048A246+ avinza&hl=en&ie=UTF-8\Docguide. Accessed on April 21, 2003. RxList. Description of levetiracetam. Available at: http://www.rxlist.com/cgi/generic3/keppra.htm]Rxlist. Accessed on April 21, 2003. National Institute on Drug Abuse. Pain and opiophobia. Available at: http://www.nida.nih.gov/ResearchReports/Prescription/ Prescription6a.html\Nida. Accessed on April 21, 2003. Fujimoto D. Regulatory issues in pain management. Clin Geriatr Med. 2001;17:537-551. Available at: http://www.partnersagainstpain.com/ html/profed/profed.htm\Partnersagainstpain. Accessed April 21, 2003. “Millions of people suffer needlessly from agonizing pain because physicians have been reluctant to use ‘high-risk’ opioids” Crain & Shen 2000 +Family Practice.com. New realities in pain management issues. Available at: https://www.familypractice.com/lectures/pain2/lecture_ mccarberg_text_frame.htm\Familypractice. Accessed on April 21, 2003. Family Practice.com. New realities in pain management issues. Available at: https://www.familypractice.com/ lectures/pain2/lecture_marcus_text_frame.htm\Familypractice. Accessed on April 21, 2003. Medscape. Barriers to effective pain management. Available at: https://www.medscape.com/viewarticle/405853_3\Medscape. Accessed on April 21, 2003. Pain and Policies Study Group, University of Wisconsin. Regulatory systems and pain management. Available at: https://www.medsch.wisc.edu/painpolicy/eguide2000/text_version/appendix_b.html\Medsch. Accessed on April 21, 2003. Pain and Policies Study Group, University of Wisconsin. Are intractable pain treatment acts what we need? Available at: https://www.medsch.wisc.edu/ painpolicy/eguide2000/text_version/ appendix_d.html\Medsch. Accessed on April 21, 2003. DrugTopics.com. Pain management regulation. Available at: https://www.drugtopics.com/be_core/ content/ journals/d/data/2003/0407/show_article.jsp?filename=dce04a2003.html\Drugtopics. Accessed on April 21, 2003. RxList. Description of diclofenac and misoprostol. Available at: https://www.rxlist.com/cgi/generic2/ arthrotec.htm\Rxlist. Accessed on April 21, 2003. Doctor’s Guide. FDA approves once-daily Avinza (extended release morphine) for chronic, moderate-to-severe pain (March 21, 2001). Available at: https://www.docguide.com/ news/content.nsf/news/ 8525697700573E1885256B830048A246+ avinza&hl=en&ie=UTF-8\Docguide. Accessed on April 21, 2003. RxList. Description of levetiracetam. Available at: https://www.rxlist.com/cgi/generic3/keppra.htm]Rxlist. Accessed on April 21, 2003. National Institute on Drug Abuse. Pain and opiophobia. Available at: https://www.nida.nih.gov/ResearchReports/Prescription/ Prescription6a.html\Nida. Accessed on April 21, 2003. Fujimoto D. Regulatory issues in pain management. Clin Geriatr Med. 2001;17:537-551. Available at: https://www.partnersagainstpain.com/ html/profed/profed.htm\Partnersagainstpain. Accessed April 21, 2003. “Millions of people suffer needlessly from agonizing pain because physicians have been reluctant to use ‘high-risk’ opioids” Crain & Shen 2000 
  
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-===== References =====+===== References =====</nodisp> 
home/symptoms/muscle_bone.txt · Last modified: 09.14.2022 by 127.0.0.1
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