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home:symptoms:neurological:fatigue [05.01.2011] – created paulalbert | home:symptoms:neurological:fatigue [01.06.2019] – [Fatigue] sallieq | ||
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====== Fatigue ====== | ====== Fatigue ====== | ||
- | Fatigue is very common in all Th1 diseases and is unrelated to [[home: | ||
+ | < | ||
+ | ====== Introduction ====== | ||
+ | Fatigue is very common in all Th1 diseases and is unrelated to [[home: | ||
- | ===== Pathology of fatigue ===== | ||
- | Most researchers believe that the fatigue so common in patients with multiple sclerosis, a typical Th1 disease, is caused by inflammatory cytokines such as TNF-alpha and interferon gamma that go along with elevated 1,25-D. | ||
- | One study found that TNF-alpha values significantly correlated with daytime sleepiness as measured by the Epworth Sleepiness Scale. Controlling for disease activity (as measured by the Cambridge Multiple Sclerosis Basic Score), disease duration, Expanded Disability Status Scale, and depression further increased the correlation of cytokine production and fatigue.(({{pubmed> | + | |
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+ | ===== Inflammation causes fatigue ===== | ||
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+ | The hallmark of chronic diseases is inflammation, | ||
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+ | For example, most researchers believe that the fatigue so common in patients with multiple sclerosis, a typical Th1 disease, is caused by inflammatory cytokines such as TNF-alpha and interferon gamma that go along with elevated 1, | ||
< | < | ||
- | ~Greg Blaney, MD</ | + | //**Greg Blaney, MD**//</ |
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+ | ==== Virtues of fatigue ===== | ||
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+ | From an evolutionary perspectives, | ||
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+ | < | ||
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+ | //**Andrew Miller**// | ||
+ | </ | ||
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===== Management of fatigue ===== | ===== Management of fatigue ===== | ||
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// | // | ||
- | {{tag> | + | {{tag>managing |
===== Notes and comments ===== | ===== Notes and comments ===== | ||
- | EDIT | + | |
*Legacy content | *Legacy content |